STRINGSTRING
cysK_1 cysK_1 cysE cysE mdlC_1 mdlC_1 dapL_1 dapL_1 serC_1 serC_1 serC_2 serC_2 hom_1 hom_1 ahcY ahcY ldhP ldhP aspA aspA yclM yclM asnO asnO asnB asnB lysA lysA serA_1 serA_1 hicd hicd ldh1_2 ldh1_2 metE metE ansB ansB metI metI yitJ yitJ metH metH dapB dapB ARK30347.1 ARK30347.1 ilvA ilvA mccB mccB hom_2 hom_2 dapA_1 dapA_1 dapL_2 dapL_2 ilvK ilvK metA metA murE_1 murE_1 mdeA_2 mdeA_2 korB korB dapA_2 dapA_2 lysC_1 lysC_1 asd asd murE_2 murE_2 ARK31187.1 ARK31187.1 dapH_1 dapH_1 ilvB_1 ilvB_1 dat_2 dat_2 leuD1 leuD1 leuC leuC leuB leuB leuA leuA ilvC ilvC ilvH ilvH ilvB_2 ilvB_2 ilvD ilvD ilvE ilvE lysC_2 lysC_2 msrC msrC ARK31775.1 ARK31775.1 metK metK patB patB dmlA dmlA dapF dapF thrB thrB thrC_1 thrC_1 hom_3 hom_3 thrC_2 thrC_2 dapE dapE serA_2 serA_2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cysK_1Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (307 aa)
cysESerine acetyltransferase. (222 aa)
mdlC_1Benzoylformate decarboxylase; Belongs to the TPP enzyme family. (570 aa)
dapL_1LL-diaminopimelate aminotransferase. (395 aa)
serC_1Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (325 aa)
serC_2Phosphoserine aminotransferase. (35 aa)
hom_1Homoserine dehydrogenase. (413 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (416 aa)
ldhPL-lactate dehydrogenase P; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (314 aa)
aspAAspartate ammonia-lyase. (472 aa)
yclMAspartokinase 3; Belongs to the aspartokinase family. (456 aa)
asnOAsparagine synthetase [glutamine-hydrolyzing] 3. (615 aa)
asnBAsparagine synthetase [glutamine-hydrolyzing] 1. (634 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (439 aa)
serA_1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (314 aa)
hicdHomoisocitrate dehydrogenase. (349 aa)
ldh1_2L-lactate dehydrogenase 1; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (315 aa)
metESensor histidine kinase ResE; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (758 aa)
ansBL-asparaginase 2 precursor. (322 aa)
metICystathionine gamma-synthase/O-acetylhomoserine (thiol)-lyase. (372 aa)
yitJBifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. (609 aa)
metHMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1148 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (267 aa)
ARK30347.1Aspartate aminotransferase. (394 aa)
ilvAL-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (415 aa)
mccBCystathionine gamma-lyase. (394 aa)
hom_2Homoserine dehydrogenase. (345 aa)
dapA_14-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa)
dapL_2LL-diaminopimelate aminotransferase. (386 aa)
ilvKBranched-chain-amino-acid aminotransferase 2. (356 aa)
metAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (307 aa)
murE_1UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD- lysine ligase; Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (479 aa)
mdeA_2Methionine gamma-lyase. (396 aa)
korB2-oxoglutarate oxidoreductase subunit KorB. (288 aa)
dapA_2Ribonuclease J 2; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (286 aa)
lysC_1Aspartokinase 2; Belongs to the aspartokinase family. (410 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (346 aa)
murE_2UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (484 aa)
ARK31187.1N-acetyldiaminopimelate deacetylase; Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate. (375 aa)
dapH_12,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (240 aa)
ilvB_1Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (585 aa)
dat_2D-alanine aminotransferase; Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction. (280 aa)
leuD13-isopropylmalate dehydratase small subunit 1; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (190 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (472 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa)
ilvHAcetolactate synthase small subunit. (173 aa)
ilvB_2Acetolactate synthase large subunit. (575 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (555 aa)
ilvEBranched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (296 aa)
lysC_2Aspartokinase; Belongs to the aspartokinase family. (415 aa)
msrCFree methionine-R-sulfoxide reductase. (159 aa)
ARK31775.1Putative dipeptidase. (515 aa)
metKS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (401 aa)
patBCystathionine beta-lyase PatB. (391 aa)
dmlAD-malate dehydrogenase, decarboxylating. (352 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (282 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (312 aa)
thrC_1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (354 aa)
hom_3Homoserine dehydrogenase. (432 aa)
thrC_2Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (388 aa)
dapEPutative succinyl-diaminopimelate desuccinylase. (401 aa)
serA_2D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (398 aa)
Your Current Organism:
Bacillus krulwichiae
NCBI taxonomy Id: 199441
Other names: B. krulwichiae, Bacillus krulwichiae Yumoto et al. 2003, Bacillus krulwichii, IAM 15000, JCM 11691, NBRC 102362, NCIMB 13904, strain AM31D
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