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pdxS_1 pdxS_1 pdxT pdxT glmM glmM glmS glmS ptsG_1 ptsG_1 mapP mapP mtlA mtlA mtlF mtlF mtlD mtlD dagK dagK degA_1 degA_1 sacX_1 sacX_1 treB_1 treB_1 rbsB_1 rbsB_1 rbsA_1 rbsA_1 rbsC_1 rbsC_1 treB_2 treB_2 malL_2 malL_2 treA_1 treA_1 treA_2 treA_2 treR treR ARK28960.1 ARK28960.1 glcR glcR lacC lacC fruA fruA ptsG_2 ptsG_2 glcT glcT deoB_1 deoB_1 deoC2 deoC2 ARK29088.1 ARK29088.1 glpF glpF glpK glpK pgcA pgcA deoC1 deoC1 glcK glcK crr crr sacY sacY iolC_1 iolC_1 deoB_2 deoB_2 ccpA_1 ccpA_1 ARK29552.1 ARK29552.1 ARK29599.1 ARK29599.1 ARK29600.1 ARK29600.1 hxlB_1 hxlB_1 hxlA_1 hxlA_1 hxlR_1 hxlR_1 zwf_1 zwf_1 gntZ_1 gntZ_1 pgiB pgiB bglF bglF fbaA_1 fbaA_1 iolC_2 iolC_2 sacC_1 sacC_1 nagA_1 nagA_1 nanA_1 nanA_1 ybbH_1 ybbH_1 nanE nanE glkA glkA sda_2 sda_2 nanA_2 nanA_2 nagB_1 nagB_1 degA_2 degA_2 bglX bglX sacC_2 sacC_2 sacB_1 sacB_1 sacB_2 sacB_2 sacA_1 sacA_1 cytR_1 cytR_1 galS galS iolC_3 iolC_3 sacA_2 sacA_2 rbsR_1 rbsR_1 rbsB_2 rbsB_2 mglA_2 mglA_2 ARK30129.1 ARK30129.1 rbsC_2 rbsC_2 dhaK_1 dhaK_1 dhaL_1 dhaL_1 ARK30201.1 ARK30201.1 plsC plsC ARK30291.1 ARK30291.1 ARK30292.1 ARK30292.1 plsY plsY gpsA gpsA pfkA_1 pfkA_1 gndA_1 gndA_1 zwf_2 zwf_2 mro mro tkt_1 tkt_1 rpe rpe gatD gatD malL_3 malL_3 malR malR fbaA_2 fbaA_2 tkt_2 tkt_2 pfkA_2 pfkA_2 xylB_1 xylB_1 rbsC_3 rbsC_3 rbsA_2 rbsA_2 rbsB_3 rbsB_3 cytR_2 cytR_2 gntZ_2 gntZ_2 zwf_3 zwf_3 hxlA_2 hxlA_2 hxlB_2 hxlB_2 ARK31464.1 ARK31464.1 ARK31466.1 ARK31466.1 ARK31467.1 ARK31467.1 ARK31468.1 ARK31468.1 ytlR ytlR yjmD yjmD ARK31476.1 ARK31476.1 ptsH_2 ptsH_2 ptsI ptsI ptsH_3 ptsH_3 gapB gapB pyk pyk pfkA_3 pfkA_3 ccpA_3 ccpA_3 pgl_3 pgl_3 pdxS_2 pdxS_2 pgi pgi eno eno tpiA tpiA pgk pgk gapA gapA xylB_2 xylB_2 xylA xylA ARK32083.1 ARK32083.1 nagC_2 nagC_2 ARK32246.1 ARK32246.1 degA_4 degA_4 opuD_4 opuD_4 amyB amyB nagB_2 nagB_2 nagA_2 nagA_2 xylB_3 xylB_3 nagA_3 nagA_3 nagB_3 nagB_3 rbsR_2 rbsR_2 ARK32432.1 ARK32432.1 srlR_2 srlR_2 tkt_3 tkt_3 glpX_1 glpX_1 dhaL_2 dhaL_2 dhaK_2 dhaK_2 ywlF_1 ywlF_1 csbX csbX ARK32490.1 ARK32490.1 rbsB_4 rbsB_4 rbsC_4 rbsC_4 rbsA_3 rbsA_3 rbsD rbsD rbsK rbsK ccpA_4 ccpA_4 acoR_3 acoR_3 glpX_2 glpX_2 tal tal fbaA_3 fbaA_3 sacX_2 sacX_2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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gene neighborhood
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gene co-occurrence
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pdxS_1Pyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (294 aa)
pdxTGlutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (196 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (447 aa)
glmSGlutamine--fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (600 aa)
ptsG_1PTS system glucose-specific EIICBA component. (547 aa)
mapPMaltose 6'-phosphate phosphatase. (263 aa)
mtlAPTS system mannitol-specific EIICBA component. (482 aa)
mtlFTranscriptional regulator MtlR; Frameshift. (145 aa)
mtlDMannitol-1-phosphate 5-dehydrogenase. (382 aa)
dagKDiacylglycerol kinase. (300 aa)
degA_1HTH-type transcriptional regulator DegA. (330 aa)
sacX_1Negative regulator of SacY activity. (107 aa)
treB_1PTS system trehalose-specific EIIBC component. (347 aa)
rbsB_1Admidase; SAM riboswitch; locus_tag BkAM31D_03195. (373 aa)
rbsA_1Ribose import ATP-binding protein RbsA. (499 aa)
rbsC_1Ribose transport system permease protein RbsC; Belongs to the binding-protein-dependent transport system permease family. (329 aa)
treB_2PTS system trehalose-specific EIIBC component. (469 aa)
malL_2Oligo-1,6-glucosidase. (564 aa)
treA_1Trehalose-6-phosphate hydrolase. (76 aa)
treA_2Trehalose-6-phosphate hydrolase. (481 aa)
treRTrehalose operon transcriptional repressor. (236 aa)
ARK28960.1Hypothetical protein; Glutathione peroxidase homolog BsaA; Belongs to the glutathione peroxidase family. (159 aa)
glcRHTH-type transcriptional repressor GlcR. (250 aa)
lacCTagatose-6-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. (307 aa)
fruAPTS system fructose-specific EIIABC component. (623 aa)
ptsG_2PTS system glucose-specific EIICBA component. (679 aa)
glcTPtsGHI operon antiterminator. (276 aa)
deoB_1Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (391 aa)
deoC2Deoxyribose-phosphate aldolase 2; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (225 aa)
ARK29088.1Glycerol-3-phosphate responsive antiterminator; Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA. (185 aa)
glpFGlycerol uptake facilitator protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (275 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (497 aa)
pgcAPhosphoglucomutase. (578 aa)
deoC1Deoxyribose-phosphate aldolase 1; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (224 aa)
glcKGlucokinase. (319 aa)
crrGlucose-specific phosphotransferase enzyme IIA component. (172 aa)
sacYLevansucrase and sucrase synthesis operon antiterminator. (283 aa)
iolC_15-dehydro-2-deoxygluconokinase; Belongs to the carbohydrate kinase PfkB family. (313 aa)
deoB_2Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (393 aa)
ccpA_1Catabolite control protein A. (328 aa)
ARK29552.1Sodium Bile acid symporter family protein. (322 aa)
ARK29599.1PTS HPr component phosphorylation site. (82 aa)
ARK29600.1Putative nucleotidyltransferase. (253 aa)
hxlB_1Putative oxidoreductase YulF, NAD-binding Rossmann fold; Frameshift. (185 aa)
hxlA_13-hexulose-6-phosphate synthase. (212 aa)
hxlR_1HTH-type transcriptional activator HxlR. (121 aa)
zwf_1Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (500 aa)
gntZ_16-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating. (297 aa)
pgiBGlucose-6-phosphate isomerase B; Belongs to the GPI family. (445 aa)
bglFPTS system beta-glucoside-specific EIIBCA component. (520 aa)
fbaA_1Low-affinity gluconate transporter; Frameshift. (278 aa)
iolC_25-dehydro-2-deoxygluconokinase. (320 aa)
sacC_1Levanase precursor; Belongs to the glycosyl hydrolase 32 family. (474 aa)
nagA_1N-acetylglucosamine-6-phosphate deacetylase. (394 aa)
nanA_1Sialidase A precursor. (800 aa)
ybbH_1Putative HTH-type transcriptional regulator YbbH. (308 aa)
nanEPutative N-acetylmannosamine-6-phosphate 2-epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (229 aa)
glkAGlucokinase. (301 aa)
sda_2Sporulation inhibitor sda. (48 aa)
nanA_2N-acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. (288 aa)
nagB_1Glucosamine-6-phosphate deaminase 1; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (245 aa)
degA_2HTH-type transcriptional regulator DegA. (345 aa)
bglXPeriplasmic beta-glucosidase precursor. (800 aa)
sacC_2Extracellular sucrase; Belongs to the glycosyl hydrolase 68 family. (456 aa)
sacB_1Levansucrase; Belongs to the glycosyl hydrolase 68 family. (448 aa)
sacB_2Levansucrase; Belongs to the glycosyl hydrolase 68 family. (448 aa)
sacA_1Sucrose-6-phosphate hydrolase; Belongs to the glycosyl hydrolase 32 family. (792 aa)
cytR_1HTH-type transcriptional repressor CytR. (147 aa)
galSHTH-type transcriptional regulator GalS. (166 aa)
iolC_35-dehydro-2-deoxygluconokinase; Belongs to the carbohydrate kinase PfkB family. (318 aa)
sacA_2Sucrose-6-phosphate hydrolase; Enables the bacterium to metabolize sucrose as a sole carbon source; Belongs to the glycosyl hydrolase 32 family. (504 aa)
rbsR_1Ribose operon repressor. (330 aa)
rbsB_2D-ribose-binding periplasmic protein precursor. (333 aa)
mglA_2Galactose/methyl galactoside import ATP-binding protein MglA. (499 aa)
ARK30129.1Ribose ABC transporter permease protein. (68 aa)
rbsC_2Ribose transport system permease protein RbsC; Belongs to the binding-protein-dependent transport system permease family. (261 aa)
dhaK_1PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK. (340 aa)
dhaL_1PTS-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL. (215 aa)
ARK30201.1Lipase (class 3). (241 aa)
plsC1-acyl-sn-glycerol-3-phosphate acyltransferase. (194 aa)
ARK30291.1Hypothetical protein. (44 aa)
ARK30292.1Hypothetical protein. (204 aa)
plsYGlycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (216 aa)
gpsAGlycerol-3-phosphate dehydrogenase, NAD(P)+; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (343 aa)
pfkA_16-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
gndA_16-phosphogluconate dehydrogenase, NADP(+)-dependent, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (469 aa)
zwf_2Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (495 aa)
mroAldose 1-epimerase precursor; Converts alpha-aldose to the beta-anomer. (347 aa)
tkt_1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (665 aa)
rpeRibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (214 aa)
gatDGalactitol-1-phosphate 5-dehydrogenase. (331 aa)
malL_3Oligo-1,6-glucosidase. (554 aa)
malRHTH-type transcriptional regulator MalR. (338 aa)
fbaA_2Putative fructose-bisphosphate aldolase. (285 aa)
tkt_2Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (669 aa)
pfkA_26-phosphofructokinase. (213 aa)
xylB_1Xylulose kinase; Belongs to the FGGY kinase family. (490 aa)
rbsC_3Ribose transport system permease protein RbsC; Belongs to the binding-protein-dependent transport system permease family. (323 aa)
rbsA_2Ribose import ATP-binding protein RbsA. (498 aa)
rbsB_3D-ribose-binding periplasmic protein precursor. (396 aa)
cytR_2HTH-type transcriptional repressor CytR. (331 aa)
gntZ_26-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating. (297 aa)
zwf_3Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (485 aa)
hxlA_23-hexulose-6-phosphate synthase. (210 aa)
hxlB_23-hexulose-6-phosphate isomerase. (185 aa)
ARK31464.1Hypothetical protein. (43 aa)
ARK31466.1Hypothetical protein. (390 aa)
ARK31467.1Hypothetical protein. (76 aa)
ARK31468.1hemolysin-III related. (215 aa)
ytlRPutative lipid kinase YtlR. (292 aa)
yjmDPutative zinc-type alcohol dehydrogenase-like protein YjmD. (412 aa)
ARK31476.1Methylthioribulose-1-phosphate dehydratase. (363 aa)
ptsH_2Phosphocarrier protein HPr. (81 aa)
ptsIPhosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (572 aa)
ptsH_3Phosphocarrier protein HPr. (87 aa)
gapBGlyceraldehyde-3-phosphate dehydrogenase 2; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (341 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (584 aa)
pfkA_36-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
ccpA_3Catabolite control protein A. (333 aa)
pgl_36-phosphogluconolactonase. (345 aa)
pdxS_2Pyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (294 aa)
pgiGlucose-6-phosphate isomerase. (380 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase 1; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
xylB_2Xylulose kinase. (499 aa)
xylAXylose isomerase; Belongs to the xylose isomerase family. (441 aa)
ARK32083.1Hypothetical protein. (202 aa)
nagC_2N-acetylglucosamine repressor. (399 aa)
ARK32246.1Membrane transport protein. (303 aa)
degA_4HTH-type transcriptional regulator DegA. (344 aa)
opuD_4Glycine betaine transporter OpuD; Belongs to the BCCT transporter (TC 2.A.15) family. (510 aa)
amyBAlpha-amylase 2; Belongs to the glycosyl hydrolase 13 family. (848 aa)
nagB_2Glucosamine-6-phosphate deaminase 1; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (245 aa)
nagA_2N-acetylglucosamine-6-phosphate deacetylase. (400 aa)
xylB_3Xylulose kinase. (504 aa)
nagA_3N-acetylglucosamine-6-phosphate deacetylase. (384 aa)
nagB_3Glucosamine-6-phosphate deaminase 1. (241 aa)
rbsR_2Ribose operon repressor. (343 aa)
ARK32432.1D-arabitol-phosphate dehydrogenase. (333 aa)
srlR_2Glucitol operon repressor. (259 aa)
tkt_3Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (670 aa)
glpX_1Fructose-1,6-bisphosphatase class 2. (330 aa)
dhaL_2PTS-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL. (217 aa)
dhaK_2PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK. (334 aa)
ywlF_1Putative sugar phosphate isomerase YwlF. (154 aa)
csbXAlpha-ketoglutarate permease. (425 aa)
ARK32490.1D-arabitol-phosphate dehydrogenase. (362 aa)
rbsB_4D-ribose-binding periplasmic protein precursor. (312 aa)
rbsC_4Ribose transport system permease protein RbsC; Belongs to the binding-protein-dependent transport system permease family. (314 aa)
rbsA_3Ribose import ATP-binding protein RbsA; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family. (498 aa)
rbsDD-ribose pyranase; Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose. (129 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (297 aa)
ccpA_4Catabolite control protein A. (329 aa)
acoR_3Acetoin dehydrogenase operon transcriptional activator AcoR. (644 aa)
glpX_2Fructose-1,6-bisphosphatase class 2. (321 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (213 aa)
fbaA_3Putative fructose-bisphosphate aldolase. (287 aa)
sacX_2Negative regulator of SacY activity. (466 aa)
Your Current Organism:
Bacillus krulwichiae
NCBI taxonomy Id: 199441
Other names: B. krulwichiae, Bacillus krulwichiae Yumoto et al. 2003, Bacillus krulwichii, IAM 15000, JCM 11691, NBRC 102362, NCIMB 13904, strain AM31D
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