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ftsH ftsH groS groS groL groL katG katG ftnA ftnA dps dps prsA prsA hrcA hrcA grpE grpE dnaK dnaK dnaJ dnaJ sodA_1 sodA_1 msrB msrB msrA_1 msrA_1 ohrB ohrB ARK29671.1 ARK29671.1 msrA3 msrA3 ARK30323.1 ARK30323.1 yfkM yfkM trxA_1 trxA_1 msrA_2 msrA_2 htpG htpG clpE clpE alaS_3 alaS_3 msrA_3 msrA_3 ARK31169.1 ARK31169.1 ARK31181.1 ARK31181.1 ykuV ykuV tsaA tsaA clpB clpB clpX clpX hflC hflC hflK hflK tpx tpx clpP clpP ARK32042.1 ARK32042.1 minJ minJ ctpB ctpB katA katA ARK32377.1 ARK32377.1 ARK32431.1 ARK32431.1 ARK32853.1 ARK32853.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ftsHATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (665 aa)
groS10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (94 aa)
groL60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (546 aa)
katGCatalase-peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (737 aa)
ftnAAerobic glycerol-3-phosphate dehydrogenase; Iron-storage protein. (168 aa)
dpsGeneral stress protein 20U; Belongs to the Dps family. (146 aa)
prsAFoldase protein PrsA precursor; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins. (298 aa)
hrcAHeat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (343 aa)
grpEHeat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] (181 aa)
dnaKChaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (610 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (369 aa)
sodA_1Superoxide dismutase, Mn; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (202 aa)
msrBPeptide methionine sulfoxide reductase MsrB. (145 aa)
msrA_1Peptide methionine sulfoxide reductase MsrA; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (179 aa)
ohrBOrganic hydroperoxide resistance protein OhrB. (140 aa)
ARK29671.1Acid shock protein; Belongs to the small heat shock protein (HSP20) family. (145 aa)
msrA3Peptide methionine sulfoxide reductase MsrA 3. (125 aa)
ARK30323.1Tetratricopeptide repeat protein. (417 aa)
yfkMGeneral stress protein 18. (173 aa)
trxA_1Thioredoxin. (113 aa)
msrA_2Peptide methionine sulfoxide reductase MsrA. (171 aa)
htpGChaperone protein HtpG; Molecular chaperone. Has ATPase activity. (626 aa)
clpEATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. (712 aa)
alaS_3Alanine--tRNA ligase. (51 aa)
msrA_3Peptide methionine sulfoxide reductase MsrA; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (176 aa)
ARK31169.1Hypothetical protein. (142 aa)
ARK31181.1Cytochrome c. (659 aa)
ykuVThiol-disulfide oxidoreductase YkuV. (150 aa)
tsaAPutative peroxiredoxin. (183 aa)
clpBChaperone protein ClpB. (308 aa)
clpXATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (424 aa)
hflCDNA polymerase I; HflC and HflK could regulate a protease. (310 aa)
hflKModulator of FtsH protease HflK; HflC and HflK could encode or regulate a protease. (338 aa)
tpxN5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (166 aa)
clpPATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (194 aa)
ARK32042.1Tetratricopeptide repeat protein. (349 aa)
minJCell division topological determinant MinJ. (395 aa)
ctpBCarboxy-terminal processing protease CtpB precursor; Belongs to the peptidase S41A family. (477 aa)
katACatalase; Belongs to the catalase family. (550 aa)
ARK32377.1Hypothetical protein. (76 aa)
ARK32431.1KAP family P-loop domain protein. (749 aa)
ARK32853.1Hypothetical protein. (393 aa)
Your Current Organism:
Bacillus krulwichiae
NCBI taxonomy Id: 199441
Other names: B. krulwichiae, Bacillus krulwichiae Yumoto et al. 2003, Bacillus krulwichii, IAM 15000, JCM 11691, NBRC 102362, NCIMB 13904, strain AM31D
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