STRINGSTRING
hprK_2 hprK_2 ARK28402.1 ARK28402.1 ispE ispE coaX_1 coaX_1 coaX_2 coaX_2 mcsB mcsB ptsG_1 ptsG_1 rsbW rsbW glxK_1 glxK_1 glxK_2 glxK_2 glxK_3 glxK_3 ypdA_1 ypdA_1 dcuS_1 dcuS_1 dagK dagK sacX_1 sacX_1 treB_1 treB_1 ARK28848.1 ARK28848.1 ARK28850.1 ARK28850.1 desK desK dcuS_2 dcuS_2 adrA adrA treB_2 treB_2 lacC lacC fruA fruA ptsG_2 ptsG_2 glpK glpK ARK29103.1 ARK29103.1 kinE_2 kinE_2 arlS arlS cssS cssS liaS_1 liaS_1 spo0B spo0B udk udk kinA_1 kinA_1 yqfL_1 yqfL_1 kinE_4 kinE_4 glcK glcK cysC cysC iolC_1 iolC_1 walK walK spoIIAB spoIIAB mtnK mtnK kdgK kdgK ypdA_2 ypdA_2 ARK29583.1 ARK29583.1 ARK29710.1 ARK29710.1 yqfL_2 yqfL_2 ARK29753.1 ARK29753.1 bglF bglF ypdA_3 ypdA_3 iolC_2 iolC_2 phoR_1 phoR_1 glkA glkA ribF_1 ribF_1 liaS_2 liaS_2 ARK30069.1 ARK30069.1 iolC_3 iolC_3 stkP stkP dhaK_1 dhaK_1 dhaL_1 dhaL_1 yehU yehU ARK30135.1 ARK30135.1 kinA_2 kinA_2 cobU_1 cobU_1 cobU_2 cobU_2 pfkA_1 pfkA_1 hssS hssS kinD_1 kinD_1 kinD_2 kinD_2 ARK30584.1 ARK30584.1 ribF_2 ribF_2 ARK31043.1 ARK31043.1 prkC_2 prkC_2 yycG_1 yycG_1 aroK aroK ARK31226.1 ARK31226.1 pfkA_2 pfkA_2 xylB_1 xylB_1 kinE_5 kinE_5 luxQ_1 luxQ_1 kinE_6 kinE_6 mrpA_2 mrpA_2 ppnK ppnK ytlR ytlR coaA coaA cheA cheA kinA_3 kinA_3 ARK31559.1 ARK31559.1 coaE coaE phoR_2 phoR_2 pyk pyk pfkA_3 pfkA_3 ppnK1 ppnK1 ARK31756.1 ARK31756.1 dcuS_3 dcuS_3 thiM thiM thrB thrB kinE_7 kinE_7 kinA_4 kinA_4 phoR_3 phoR_3 ARK32038.1 ARK32038.1 hprK_1 hprK_1 xylB_2 xylB_2 degS degS rsiV rsiV garK garK ARK32359.1 ARK32359.1 xylB_3 xylB_3 ywqD ywqD cap8A cap8A dhaL_2 dhaL_2 dhaK_2 dhaK_2 rbsK rbsK kinA_5 kinA_5 graS graS phoR_4 phoR_4 kinA_6 kinA_6 sacX_2 sacX_2 kinA_7 kinA_7 yycG_2 yycG_2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
hprK_2HPr kinase/phosphorylase; Belongs to the HPrK/P family. (311 aa)
ARK28402.1Hypothetical protein. (319 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (287 aa)
coaX_1Type III pantothenate kinase. (170 aa)
coaX_2Type III pantothenate kinase. (68 aa)
mcsBPutative ATP:guanido phosphotransferase; Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity. (358 aa)
ptsG_1PTS system glucose-specific EIICBA component. (547 aa)
rsbWSerine-protein kinase RsbW; Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B). (161 aa)
glxK_1Glycerate kinase. (68 aa)
glxK_2Glycerate kinase. (167 aa)
glxK_3Glycerate kinase. (129 aa)
ypdA_1Sensor histidine kinase YpdA. (474 aa)
dcuS_1Sensor histidine kinase DcuS. (551 aa)
dagKDiacylglycerol kinase. (300 aa)
sacX_1Negative regulator of SacY activity. (107 aa)
treB_1PTS system trehalose-specific EIIBC component. (347 aa)
ARK28848.1Hypothetical protein. (274 aa)
ARK28850.1Hypothetical protein. (216 aa)
desKSensor histidine kinase DesK. (378 aa)
dcuS_2Sensor histidine kinase DcuS. (528 aa)
adrAPutative diguanylate cyclase AdrA. (362 aa)
treB_2PTS system trehalose-specific EIIBC component. (469 aa)
lacCTagatose-6-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. (307 aa)
fruAPTS system fructose-specific EIIABC component. (623 aa)
ptsG_2PTS system glucose-specific EIICBA component. (679 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (497 aa)
ARK29103.1PrkA AAA domain protein. (631 aa)
kinE_2Sporulation kinase E. (752 aa)
arlSSignal transduction histidine-protein kinase ArlS. (707 aa)
cssSSensor histidine kinase CssS. (455 aa)
liaS_1Sensor histidine kinase LiaS. (355 aa)
spo0BSporulation initiation phosphotransferase B. (176 aa)
udkUridine kinase. (211 aa)
kinA_1Sporulation kinase A. (374 aa)
yqfL_1Putative pyruvate, phosphate dikinase regulatory protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (271 aa)
kinE_4Sporulation kinase E. (378 aa)
glcKGlucokinase. (319 aa)
cysCPutative adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (197 aa)
iolC_15-dehydro-2-deoxygluconokinase; Belongs to the carbohydrate kinase PfkB family. (313 aa)
walKSensor protein kinase WalK. (739 aa)
spoIIABAnti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. (146 aa)
mtnKMethylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (406 aa)
kdgK2-dehydro-3-deoxygluconokinase; Belongs to the carbohydrate kinase PfkB family. (317 aa)
ypdA_2Sensor histidine kinase YpdA. (585 aa)
ARK29583.1Hypothetical protein. (230 aa)
ARK29710.1Hypothetical protein. (257 aa)
yqfL_2Putative pyruvate, phosphate dikinase regulatory protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (269 aa)
ARK29753.1Hypothetical protein. (219 aa)
bglFPTS system beta-glucoside-specific EIIBCA component. (520 aa)
ypdA_3Sensor histidine kinase YpdA. (584 aa)
iolC_25-dehydro-2-deoxygluconokinase. (320 aa)
phoR_1Alkaline phosphatase synthesis sensor protein PhoR. (460 aa)
glkAGlucokinase. (301 aa)
ribF_1Riboflavin biosynthesis protein RibF. (262 aa)
liaS_2ABC-2 family transporter protein; Frameshift. (368 aa)
ARK30069.1Putative sensor-like histidine kinase. (602 aa)
iolC_35-dehydro-2-deoxygluconokinase; Belongs to the carbohydrate kinase PfkB family. (318 aa)
stkPSerine/threonine-protein kinase StkP. (508 aa)
dhaK_1PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK. (340 aa)
dhaL_1PTS-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL. (215 aa)
yehUSensor histidine kinase YehU. (262 aa)
ARK30135.1Hypothetical protein. (227 aa)
kinA_2Sporulation kinase A. (518 aa)
cobU_1Bifunctional adenosylcobalamin biosynthesis protein CobU. (197 aa)
cobU_2Bifunctional adenosylcobalamin biosynthesis protein CobU. (114 aa)
pfkA_16-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
hssSHeme sensor protein HssS. (434 aa)
kinD_1Sporulation kinase D. (502 aa)
kinD_2Sporulation kinase D. (192 aa)
ARK30584.1Sensory histidine kinase AtoS. (389 aa)
ribF_2Riboflavin biosynthesis protein RibF; Belongs to the ribF family. (312 aa)
ARK31043.1DAK2 domain protein. (561 aa)
prkC_2Serine/threonine-protein kinase PrkC. (678 aa)
yycG_1Sensor histidine kinase YycG. (463 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (182 aa)
ARK31226.1Putative sensor-like histidine kinase. (585 aa)
pfkA_26-phosphofructokinase. (213 aa)
xylB_1Xylulose kinase; Belongs to the FGGY kinase family. (490 aa)
kinE_5Sporulation kinase E. (655 aa)
luxQ_1Autoinducer 2 sensor kinase/phosphatase LuxQ. (906 aa)
kinE_6Sporulation kinase E. (343 aa)
mrpA_2Na(+)/H(+) antiporter subunit A; Frameshift. (228 aa)
ppnKPutative inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (264 aa)
ytlRPutative lipid kinase YtlR. (292 aa)
coaAPantothenate kinase. (317 aa)
cheAChemotaxis protein CheA. (701 aa)
kinA_3Sporulation kinase A. (349 aa)
ARK31559.1DNA-binding transcriptional regulator DhaR. (82 aa)
coaEDephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (198 aa)
phoR_2Alkaline phosphatase synthesis sensor protein PhoR. (592 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (584 aa)
pfkA_36-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
ppnK1Putative inorganic polyphosphate/ATP-NAD kinase 1; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (272 aa)
ARK31756.1Hypothetical protein. (342 aa)
dcuS_3Sensor histidine kinase DcuS. (529 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (262 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (312 aa)
kinE_7Sporulation kinase E. (548 aa)
kinA_4Sporulation kinase A. (280 aa)
phoR_3Putative membrane protein SCO5905; Frameshift. (472 aa)
ARK32038.1Gluconeogenesis factor; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (315 aa)
hprK_1HPr kinase/phosphorylase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon [...] (312 aa)
xylB_2Xylulose kinase. (499 aa)
degSSignal transduction histidine-protein kinase/phosphatase DegS; Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase. (374 aa)
rsiVAnti-sigma-V factor RsiV. (576 aa)
garKGlycerate 2-kinase; Belongs to the glycerate kinase type-1 family. (382 aa)
ARK32359.1dephospho-CoA kinase/protein folding accessory domain-containing protein. (170 aa)
xylB_3Xylulose kinase. (504 aa)
ywqDTyrosine-protein kinase YwqD. (233 aa)
cap8ACapsular polysaccharide type 8 biosynthesis protein cap8A. (233 aa)
dhaL_2PTS-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL. (217 aa)
dhaK_2PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK. (334 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (297 aa)
kinA_5Sporulation kinase A. (556 aa)
graSSensor histidine kinase GraS. (334 aa)
phoR_4Alkaline phosphatase synthesis sensor protein PhoR. (458 aa)
kinA_6Sporulation kinase A. (595 aa)
sacX_2Negative regulator of SacY activity. (466 aa)
kinA_7Sporulation kinase A. (402 aa)
yycG_2Sensor histidine kinase YycG. (608 aa)
Your Current Organism:
Bacillus krulwichiae
NCBI taxonomy Id: 199441
Other names: B. krulwichiae, Bacillus krulwichiae Yumoto et al. 2003, Bacillus krulwichii, IAM 15000, JCM 11691, NBRC 102362, NCIMB 13904, strain AM31D
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