STRINGSTRING
DES48_103244 DES48_103244 serC serC DES48_102108 DES48_102108 DES48_102109 DES48_102109 DES48_102206 DES48_102206 trpE trpE DES48_102209 DES48_102209 trpD trpD trpC trpC trpF trpF trpB trpB trpA trpA DES48_10617 DES48_10617 aroD aroD DES48_106116 DES48_106116 DES48_106117 DES48_106117 thrB thrB DES48_1075 DES48_1075 leuD leuD leuC leuC leuB leuB leuA leuA ilvC ilvC DES48_11025 DES48_11025 DES48_11024 DES48_11024 DES48_1108 DES48_1108 DES48_101400 DES48_101400 ilvA ilvA aroA aroA DES48_101276 DES48_101276 DES48_101274 DES48_101274 aroB aroB aroC aroC DES48_10428 DES48_10428 pheA pheA aroE aroE aroK aroK DES48_1147 DES48_1147 ilvD ilvD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DES48_103244Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (528 aa)
serCUnannotated protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (362 aa)
DES48_102108Unannotated protein. (165 aa)
DES48_102109Unannotated protein. (391 aa)
DES48_102206Unannotated protein. (182 aa)
trpEUnannotated protein; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (459 aa)
DES48_102209Unannotated protein. (199 aa)
trpDUnannotated protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (340 aa)
trpCUnannotated protein; Belongs to the TrpC family. (257 aa)
trpFUnannotated protein; Belongs to the TrpF family. (202 aa)
trpBUnannotated protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (401 aa)
trpAUnannotated protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (259 aa)
DES48_10617Unannotated protein. (580 aa)
aroDUnannotated protein; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (253 aa)
DES48_106116Unannotated protein. (430 aa)
DES48_106117Unannotated protein; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (353 aa)
thrBUnannotated protein; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (295 aa)
DES48_1075Unannotated protein; Belongs to the TPP enzyme family. (571 aa)
leuDUnannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (196 aa)
leuCUnannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (471 aa)
leuBUnannotated protein; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (353 aa)
leuAUnannotated protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa)
ilvCUnannotated protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (343 aa)
DES48_11025Unannotated protein. (174 aa)
DES48_11024Unannotated protein. (577 aa)
DES48_1108Unannotated protein. (385 aa)
DES48_101400Unannotated protein. (359 aa)
ilvAUnannotated protein; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (420 aa)
aroAUnannotated protein; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (429 aa)
DES48_101276Unannotated protein. (366 aa)
DES48_101274Unannotated protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (121 aa)
aroBUnannotated protein; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (359 aa)
aroCUnannotated protein; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (387 aa)
DES48_10428Unannotated protein. (353 aa)
pheAUnannotated protein. (284 aa)
aroEUnannotated protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (278 aa)
aroKUnannotated protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (166 aa)
DES48_1147Unannotated protein; Belongs to the phosphoglycerate mutase family. (188 aa)
ilvDUnannotated protein; Belongs to the IlvD/Edd family. (560 aa)
Your Current Organism:
Paraliobacillus ryukyuensis
NCBI taxonomy Id: 200904
Other names: DSM 15140, IAM 15001, JCM 21472, NBRC 100001, NRIC 0520, P. ryukyuensis, Paraliobacillus ryukyuensis Ishikawa et al. 2003, strain O15-7
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