STRINGSTRING
leuB leuB DES48_109122 DES48_109122 mtlD mtlD DES48_103134 DES48_103134 DES48_103121 DES48_103121 DES48_103118 DES48_103118 murB murB DES48_10363 DES48_10363 DES48_108147 DES48_108147 zwf zwf DES48_10849 DES48_10849 DES48_11114 DES48_11114 aroE aroE DES48_10477 DES48_10477 DES48_10467 DES48_10467 DES48_10453 DES48_10453 gpsA gpsA DES48_101358 DES48_101358 hisD hisD DES48_101649 DES48_101649 ilvC ilvC DES48_105137 DES48_105137 DES48_10764 DES48_10764 DES48_106116 DES48_106116 ldh ldh DES48_102385 DES48_102385 DES48_102165 DES48_102165 DES48_102160 DES48_102160 DES48_10916 DES48_10916 DES48_103244 DES48_103244 guaB guaB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
leuBUnannotated protein; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (353 aa)
DES48_109122Unannotated protein. (369 aa)
mtlDUnannotated protein. (385 aa)
DES48_103134Unannotated protein; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (431 aa)
DES48_103121Unannotated protein; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (865 aa)
DES48_103118Unannotated protein. (388 aa)
murBUnannotated protein; Cell wall formation. (305 aa)
DES48_10363Unannotated protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (363 aa)
DES48_108147Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (316 aa)
zwfUnannotated protein; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
DES48_10849Unannotated protein; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (472 aa)
DES48_11114Unannotated protein. (442 aa)
aroEUnannotated protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (278 aa)
DES48_10477Unannotated protein. (424 aa)
DES48_10467Unannotated protein. (393 aa)
DES48_10453Unannotated protein. (251 aa)
gpsAUnannotated protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (346 aa)
DES48_101358Unannotated protein; Belongs to the HMG-CoA reductase family. (428 aa)
hisDUnannotated protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa)
DES48_101649Unannotated protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (291 aa)
ilvCUnannotated protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (343 aa)
DES48_105137Unannotated protein. (253 aa)
DES48_10764Unannotated protein. (441 aa)
DES48_106116Unannotated protein. (430 aa)
ldhUnannotated protein; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (321 aa)
DES48_102385Unannotated protein. (388 aa)
DES48_102165Unannotated protein. (354 aa)
DES48_102160Unannotated protein. (343 aa)
DES48_10916Unannotated protein. (338 aa)
DES48_103244Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (528 aa)
guaBUnannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa)
Your Current Organism:
Paraliobacillus ryukyuensis
NCBI taxonomy Id: 200904
Other names: DSM 15140, IAM 15001, JCM 21472, NBRC 100001, NRIC 0520, P. ryukyuensis, Paraliobacillus ryukyuensis Ishikawa et al. 2003, strain O15-7
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