(29 nodes) Regulation of ERK1 and ERK2 cascade network (Ooceraea biroi)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	X777_16526	Sprouty-related, EVH1 domain-containing protein. (297 aa)
	X777_02961	Connector enhancer of kinase suppressor of ras. (1830 aa)
	X777_02914	E3 ubiquitin-protein ligase UBR4. (5241 aa)
	X777_05594	Receptor protein-tyrosine kinase. (1487 aa)
	DMN91_000315	Protein giant-lens. (301 aa)
	DMN91_011796	Ribosomal protein S6 kinase. (746 aa)
	X777_08899	E3 ubiquitin-protein ligase CBL-B. (762 aa)
	X777_07283	Ubiquitin-conjugating enzyme E2-17 kDa; Belongs to the ubiquitin-conjugating enzyme family. (118 aa)
	DMN91_003861	SH2B adapter protein. (640 aa)
	X777_09646	Protein purity of essence. (50 aa)
	X777_10035	Receptor-type tyrosine-protein phosphatase R. (543 aa)
	X777_11323	Protein sprouty. (475 aa)
	DMN91_005536	Protein vav. (646 aa)
	X777_11502	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; Belongs to the cyclic nucleotide phosphodiesterase family. (842 aa)
	X777_11694	Protein vav. (820 aa)
	DMN91_004419	Dual specificity protein phosphatase. (402 aa)
	X777_12599	Kinase suppressor of Ras. (901 aa)
	X777_15352	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1198 aa)
	DMN91_003203	Ras-related protein Rap-1b. (184 aa)
	X777_03733	Ubiquitin carboxyl-terminal hydrolase 64E; Belongs to the peptidase C19 family. (1307 aa)
	X777_08151	Serine/threonine/tyrosine-interacting protein B. (243 aa)
	X777_08215	Protein vein. (416 aa)
	X777_08367	E3 ubiquitin-protein ligase HECTD1. (2501 aa)
	X777_00345	Dedicator of cytokinesis protein; Belongs to the DOCK family. (1735 aa)
	DMN91_008089	Protein E(Sev)2B. (211 aa)
	X777_14762	Tyrosine-protein phosphatase non-receptor type 61F. (495 aa)
	X777_00844	Leukocyte tyrosine kinase receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1497 aa)
	X777_14761	Uncharacterized protein. (120 aa)
	X777_03122	Cytohesin-1. (369 aa)

Your Current Organism:

Ooceraea biroi

NCBI taxonomy Id: 2015173
Other names: Cerapachys biroi, O. biroi, clonal raider ant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DMN91_003203	DMN91_008089	A0A026VTT4	A0A026WTT4	Ras-related protein Rap-1b.	Protein E(Sev)2B.	0.705
DMN91_003203	X777_02961	A0A026VTT4	A0A026WJW5	Ras-related protein Rap-1b.	Connector enhancer of kinase suppressor of ras.	0.583
DMN91_003203	X777_12599	A0A026VTT4	A0A026VZX2	Ras-related protein Rap-1b.	Kinase suppressor of Ras.	0.723
DMN91_003861	DMN91_008089	A0A026W9U4	A0A026WTT4	SH2B adapter protein.	Protein E(Sev)2B.	0.677
DMN91_003861	X777_08899	A0A026W9U4	A0A026WB25	SH2B adapter protein.	E3 ubiquitin-protein ligase CBL-B.	0.705
DMN91_005536	DMN91_008089	A0A026W1X0	A0A026WTT4	Protein vav.	Protein E(Sev)2B.	0.861
DMN91_005536	X777_08899	A0A026W1X0	A0A026WB25	Protein vav.	E3 ubiquitin-protein ligase CBL-B.	0.742
DMN91_005536	X777_15352	A0A026W1X0	A0A026VXP9	Protein vav.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.659
DMN91_008089	DMN91_003203	A0A026WTT4	A0A026VTT4	Protein E(Sev)2B.	Ras-related protein Rap-1b.	0.705
DMN91_008089	DMN91_003861	A0A026WTT4	A0A026W9U4	Protein E(Sev)2B.	SH2B adapter protein.	0.677
DMN91_008089	DMN91_005536	A0A026WTT4	A0A026W1X0	Protein E(Sev)2B.	Protein vav.	0.861
DMN91_008089	X777_00844	A0A026WTT4	A0A026WRL6	Protein E(Sev)2B.	Leukocyte tyrosine kinase receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.669
DMN91_008089	X777_05594	A0A026WTT4	A0A026WH10	Protein E(Sev)2B.	Receptor protein-tyrosine kinase.	0.873
DMN91_008089	X777_08215	A0A026WTT4	A0A026WYU9	Protein E(Sev)2B.	Protein vein.	0.523
DMN91_008089	X777_08899	A0A026WTT4	A0A026WB25	Protein E(Sev)2B.	E3 ubiquitin-protein ligase CBL-B.	0.992
DMN91_008089	X777_10035	A0A026WTT4	A0A026W5K0	Protein E(Sev)2B.	Receptor-type tyrosine-protein phosphatase R.	0.409
DMN91_008089	X777_11323	A0A026WTT4	A0A026W2B6	Protein E(Sev)2B.	Protein sprouty.	0.987
DMN91_008089	X777_11694	A0A026WTT4	A0A026W1T4	Protein E(Sev)2B.	Protein vav.	0.861
DMN91_008089	X777_12599	A0A026WTT4	A0A026VZX2	Protein E(Sev)2B.	Kinase suppressor of Ras.	0.534
DMN91_008089	X777_14761	A0A026WTT4	A0A026WRE8	Protein E(Sev)2B.	Uncharacterized protein.	0.459