STRINGSTRING
thiG thiG SFF67320.1 SFF67320.1 SFF67332.1 SFF67332.1 thiE thiE SFF67364.1 SFF67364.1 SFF67389.1 SFF67389.1 SFF67403.1 SFF67403.1 SFF67415.1 SFF67415.1 thiM thiM SFF75373.1 SFF75373.1 SFF75387.1 SFF75387.1 SFF75404.1 SFF75404.1 menG menG SFF75440.1 SFF75440.1 ubiX ubiX mqnA mqnA SFF75489.1 SFF75489.1 mqnC mqnC thiE-2 thiE-2 SFF87437.1 SFF87437.1 mqnD mqnD mqnB mqnB SFG03770.1 SFG03770.1 SFG03799.1 SFG03799.1 SFG06123.1 SFG06123.1 mqnE mqnE thiC thiC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (255 aa)
SFF67320.1Sulfur carrier protein. (58 aa)
SFF67332.1Glycine oxidase. (370 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (222 aa)
SFF67364.1Membrane protein DedA, SNARE-associated domain. (205 aa)
SFF67389.1Nicotinamidase-related amidase. (244 aa)
SFF67403.1Endoglucanase. (360 aa)
SFF67415.1Uncharacterized protein, MTH1187 family. (100 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (269 aa)
SFF75373.1Transcription attenuation protein (tryptophan RNA-binding attenuator protein). (71 aa)
SFF75387.1Hypothetical protein. (168 aa)
SFF75404.1Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1. (255 aa)
menGDemethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (250 aa)
SFF75440.14-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. (293 aa)
ubiX4-hydroxy-3-polyprenylbenzoate decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (197 aa)
mqnAChorismate dehydratase; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (280 aa)
SFF75489.1Heptaprenyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (361 aa)
mqnCDe-hypoxanthine futalosine cyclase; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (369 aa)
thiE-2Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (227 aa)
SFF87437.1Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (268 aa)
mqnD1,4-dihydroxy-6-naphthoate synthase; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (276 aa)
mqnBFutalosine hydrolase; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (223 aa)
SFG03770.1Molybdopterin synthase catalytic subunit. (240 aa)
SFG03799.1Adenylyltransferase and sulfurtransferase. (342 aa)
SFG06123.1Menaquinone biosynthesis decarboxylase, SCO4490 family; Belongs to the UbiD family. (585 aa)
mqnEAminodeoxyfutalosine synthase; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (365 aa)
thiCHydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (582 aa)
Your Current Organism:
Planifilum fulgidum
NCBI taxonomy Id: 201973
Other names: ATCC BAA-970, DSM 44945, JCM 12508, P. fulgidum, Planifilum fulgidum Hatayama et al. 2005, Planifilum fulgidus, Thermoactinomyces sp. 500275, Thermoactinomyces sp. 700375, Thermoactinomyces sp. C0170, strain 500275
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