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infA infA rpsR rpsR rplI rplI rpsO rpsO rpmI rpmI rplT rplT rplM rplM rpsB_1 rpsB_1 rplY rplY rpmA rpmA rplU rplU rpmG rpmG rpmB rpmB rplS rplS rplQ rplQ rpsD_2 rpsD_2 rpsM rpsM rplO rplO rpmD rpmD rpsE_1 rpsE_1 rplR rplR rplF_1 rplF_1 rpsH_2 rpsH_2 rplE_1 rplE_1 rplX rplX rplN_1 rplN_1 rpsQ rpsQ ACEE_09000 ACEE_09000 rplP rplP rpsC_1 rpsC_1 rplV rplV rpsS_1 rpsS_1 rplB rplB rplW rplW rplD rplD rplC_2 rplC_2 rpsJ rpsJ selB_4 selB_4 rplL rplL rplJ rplJ rplA rplA rplK rplK rpsL rpsL rpsG_2 rpsG_2 rpmF rpmF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
infATranslation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa)
rpsR30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (75 aa)
rplI50S ribosomal protein L9; In Escherichia coli this protein is wrapped around the base of the L1 stalk; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
rpsO30S ribosomal protein S15; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS15 family. (89 aa)
rpmI50S ribosomal protein L35; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL35 family. (65 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (117 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
rpsB_130S ribosomal protein S2; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS2 family. (238 aa)
rplY50S ribosomal protein L25; The Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; Derived by automated computational analysis using gene prediction method: Protein Homology. (95 aa)
rpmA50S ribosomal protein L27; Involved in the peptidyltransferase reaction during translation; Derived by automated computational analysis using gene prediction method: Protein Homology. (85 aa)
rplU50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
rpmG50S ribosomal protein L33; In Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; Derived by automated computational analysis using gene prediction method: Protein Homology. (56 aa)
rpmB50S ribosomal protein L28; Required for 70S ribosome assembly; Derived by automated computational analysis using gene prediction method: Protein Homology. (78 aa)
rplS50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (116 aa)
rplQ50S ribosomal protein L17; Is a component of the macrolide binding site in the peptidyl transferase center; Derived by automated computational analysis using gene prediction method: Protein Homology. (127 aa)
rpsD_230S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (208 aa)
rpsM30S ribosomal protein S13; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS13 family. (118 aa)
rplO50S ribosomal protein L15; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
rpmD50S ribosomal protein L30; L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; Derived by automated computational analysis using gene prediction method: Protein Homology. (59 aa)
rpsE_130S ribosomal protein S5; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
rplR50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (117 aa)
rplF_150S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. (177 aa)
rpsH_230S ribosomal protein S8; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
rplE_150S ribosomal protein L5; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)
rplX50S ribosomal protein L24; Assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; Derived by automated computational analysis using gene prediction method: Protein Homology. (103 aa)
rplN_150S ribosomal protein L14; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uL14 family. (123 aa)
rpsQ30S ribosomal protein S17; Derived by automated computational analysis using gene prediction method: Protein Homology. (84 aa)
ACEE_0900050S ribosomal protein L29; One of the stabilizing components for the large ribosomal subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (63 aa)
rplP50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (136 aa)
rpsC_130S ribosomal protein S3; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS3 family. (234 aa)
rplV50S ribosomal protein L22; Derived by automated computational analysis using gene prediction method: Protein Homology. (110 aa)
rpsS_130S ribosomal protein S19; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS19 family. (91 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (273 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (101 aa)
rplDL4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
rplC_250S ribosomal protein L3; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
selB_4Translation elongation factor; Derived by automated computational analysis using gene prediction method: Protein Homology. (616 aa)
rplL50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (163 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (229 aa)
rplK50S ribosomal protein L11; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
rpsL30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (124 aa)
rpsG_230S ribosomal protein S7; Derived by automated computational analysis using gene prediction method: Protein Homology. (156 aa)
rpmFSome L32 proteins have zinc finger motifs consisting of CXXC while others do not; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL32 family. (56 aa)
Your Current Organism:
Actinobacillus equuli
NCBI taxonomy Id: 202947
Other names: A. equuli subsp. equuli, Actinobacillus equuli subsp. equuli
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