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ureA ureA ureB ureB ureC ureC Sde_0370 Sde_0370 cpdA cpdA Sde_0580 Sde_0580 purC purC apaH apaH Sde_0780 Sde_0780 purD purD purH purH purN purN purM purM Sde_1069 Sde_1069 Sde_1173 Sde_1173 Sde_1254 Sde_1254 Sde_1308 Sde_1308 Sde_1377 Sde_1377 ndk ndk guaB guaB guaA guaA purL purL ppnP ppnP Sde_1665 Sde_1665 Sde_1675 Sde_1675 Sde_1792 Sde_1792 Sde_1861 Sde_1861 purF purF cysC cysC cysN cysN cysD cysD adk adk Sde_2237 Sde_2237 Sde_2238 Sde_2238 nrdA nrdA nrdB1 nrdB1 purA purA purK purK purE purE Sde_3065 Sde_3065 prs prs Sde_3378 Sde_3378 nrdB2 nrdB2 Sde_3600 Sde_3600 Sde_3623 Sde_3623 Sde_3624 Sde_3624 Sde_3647 Sde_3647 Sde_3676 Sde_3676 gmk gmk Sde_3697 Sde_3697
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ureAUrease, gamma subunit; Belongs to the urease gamma subunit family. (100 aa)
ureBUrease, beta subunit; Belongs to the urease beta subunit family. (101 aa)
ureCUrease. Metallo peptidase. MEROPS family M38; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family. (568 aa)
Sde_0370Nucleoside diphosphate pyrophosphatase. (205 aa)
cpdAMetallophosphoesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (271 aa)
Sde_05805'-Nucleotidase-like protein; Belongs to the 5'-nucleotidase family. (748 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (367 aa)
apaHBis(5'-nucleosyl)-tetraphosphatase (symmetrical); Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. (271 aa)
Sde_07805'-Nucleotidase-like protein; Belongs to the 5'-nucleotidase family. (671 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (430 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. (526 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (219 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (369 aa)
Sde_1069Conserved hypothetical protein 730. (454 aa)
Sde_1173Adenylyl cyclase class-3/4/guanylyl cyclase. (460 aa)
Sde_1254Phosphoglucomutase, alpha-D-glucose phosphate-specific. (546 aa)
Sde_1308Pyruvate kinase; Belongs to the pyruvate kinase family. (480 aa)
Sde_1377Adenylyl cyclase class-3/4/guanylyl cyclase. (294 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (556 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (542 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1290 aa)
ppnPProtein of unknown function DUF1255; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (94 aa)
Sde_16655-nucleotidase. (304 aa)
Sde_1675Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (459 aa)
Sde_1792Phosphoribosyltransferase. (191 aa)
Sde_1861Ppx/GppA phosphatase; Belongs to the GppA/Ppx family. (505 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (504 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (199 aa)
cysNSulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (471 aa)
cysDSulfate adenylyltransferase subunit 2. (303 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (218 aa)
Sde_2237MazG family protein. (272 aa)
Sde_2238RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (746 aa)
nrdARibonucleoside-diphosphate reductase class Ia alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (969 aa)
nrdB1Class Ia ribonucleoside-diphosphate reductase beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (423 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (367 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (168 aa)
Sde_3065NUDIX hydrolase. (181 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (313 aa)
Sde_3378Deoxynucleoside kinase. (230 aa)
nrdB2Class Ia ribonucleoside-diphosphate reductase beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (368 aa)
Sde_3600Adenylate cyclase. (954 aa)
Sde_3623Transcription termination factor Rho. (182 aa)
Sde_3624HAD-superfamily hydrolase subfamily IA, variant 3. (222 aa)
Sde_3647Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (200 aa)
Sde_3676Phosphomannomutase. (830 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (225 aa)
Sde_3697RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (702 aa)
Your Current Organism:
Saccharophagus degradans
NCBI taxonomy Id: 203122
Other names: Microbulbifer degradans 2-40, Microbulbifer sp. 2-40, S. degradans 2-40, Saccharophagus degradans 2-40, Saccharophagus degradans ATCC 43961, Saccharophagus degradans str. 2-40, Saccharophagus degradans strain 2-40, bacterium 2-40
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