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ces1B ces1B Sde_0052 Sde_0052 gcvT gcvT gcvH gcvH glyA glyA Sde_0468 Sde_0468 Sde_0472 Sde_0472 pgk pgk gpmI gpmI Sde_0612 Sde_0612 Sde_0635 Sde_0635 Sde_0661 Sde_0661 tpiA tpiA Sde_0746 Sde_0746 tal tal Sde_0811 Sde_0811 Sde_0812 Sde_0812 Sde_0830 Sde_0830 Sde_0888 Sde_0888 Sde_0904 Sde_0904 pfp pfp Sde_0939 Sde_0939 pckA pckA pgi pgi glk glk acsA-2 acsA-2 Sde_1075 Sde_1075 Sde_1084 Sde_1084 accA accA eno eno Sde_1269 Sde_1269 Sde_1277 Sde_1277 fbp fbp Sde_1308 Sde_1308 Sde_1330 Sde_1330 Sde_1332 Sde_1332 Sde_1333 Sde_1333 Sde_1379 Sde_1379 zwf zwf edd edd Sde_1382 Sde_1382 Sde_1446 Sde_1446 tal-2 tal-2 Sde_1605 Sde_1605 mdh mdh Sde_1670 Sde_1670 Sde_1684 Sde_1684 Sde_1893 Sde_1893 folD folD Sde_1991 Sde_1991 fumC fumC gpmA gpmA accD accD sucD sucD sucC sucC Sde_2104 Sde_2104 Sde_2105 Sde_2105 Sde_2106 Sde_2106 Sde_2107 Sde_2107 Sde_2108 Sde_2108 Sde_2109 Sde_2109 Sde_2110 Sde_2110 Sde_2111 Sde_2111 gcvP gcvP Sde_2572 Sde_2572 Sde_2573 Sde_2573 fabV fabV Sde_2656 Sde_2656 tpiA-2 tpiA-2 Sde_2901 Sde_2901 Sde_2970 Sde_2970 Sde_3149 Sde_3149 Sde_3207 Sde_3207 prs prs tpiA-3 tpiA-3 Sde_3279 Sde_3279 Sde_3280 Sde_3280 ppc ppc ilvA ilvA rpiA rpiA Sde_3388 Sde_3388 Sde_3872 Sde_3872
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query proteins and first shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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ces1BEsterase-like protein; Serine hydrolase involved in the detoxification of formaldehyde. (280 aa)
Sde_0052Alcohol dehydrogenase GroES-like protein; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (376 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (363 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (130 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
Sde_04685,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (297 aa)
Sde_0472Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (667 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (391 aa)
gpmIPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (516 aa)
Sde_0612Protein of unknown function DUF1124, sugar phosphate isomerase putative. (212 aa)
Sde_06356-phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (484 aa)
Sde_0661Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+). (535 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (257 aa)
Sde_0746Ribulose-5-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (318 aa)
Sde_0811acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa)
Sde_0812Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (151 aa)
Sde_0830Catalase. (480 aa)
Sde_0888Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (506 aa)
Sde_0904Gluconate kinase. (184 aa)
pfp6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (429 aa)
Sde_09392-keto-3-deoxygluconate kinase. (318 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (551 aa)
pgiGlucose-6-phosphate isomerase. (547 aa)
glkGlucokinase; Belongs to the bacterial glucokinase family. (321 aa)
acsA-2Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (645 aa)
Sde_1075Methyl-accepting chemotaxis sensory transducer / phosphoserine phosphatase. (405 aa)
Sde_1084Serine O-acetyltransferase. (277 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (318 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (428 aa)
Sde_12692-keto-3-deoxygluconate kinase. (296 aa)
Sde_1277Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa)
fbpD-fructose 1,6-bisphosphatase. (322 aa)
Sde_1308Pyruvate kinase; Belongs to the pyruvate kinase family. (480 aa)
Sde_13303-oxoacyl-[acyl-carrier-protein] reductase. (240 aa)
Sde_1332Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (371 aa)
Sde_1333D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (390 aa)
Sde_1379Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
edd6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (609 aa)
Sde_13822-keto-3-deoxy-phosphogluconate aldolase. (209 aa)
Sde_1446Conserved hypothetical protein. (372 aa)
tal-2Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (310 aa)
Sde_16053-hydroxyacyl-CoA dehydrogenase / short chain enoyl-CoA hydratase; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (721 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (327 aa)
Sde_1670Phosphoserine phosphatase / phosphoserine:homoserine phosphotransferase / homoserine kinase. (205 aa)
Sde_1684Isocitrate dehydrogenase, NADP-dependent; Belongs to the monomeric-type IDH family. (742 aa)
Sde_1893Aconitase / transcriptional regulator, XRE family; Belongs to the aconitase/IPM isomerase family. (874 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (280 aa)
Sde_1991Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (937 aa)
fumCFumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (460 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (229 aa)
accDAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (287 aa)
sucDsuccinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
sucCsuccinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
Sde_2104Dihydrolipoamide dehydrogenase. (484 aa)
Sde_21052-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (403 aa)
Sde_21062-oxoglutarate dehydrogenase E1 component. (953 aa)
Sde_2107Succinate dehydrogenase subunit B. (234 aa)
Sde_2108Succinate dehydrogenase subunit A; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (590 aa)
Sde_2109Succinate dehydrogenase subunit D; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (122 aa)
Sde_2110Succinate dehydrogenase subunit C. (124 aa)
Sde_2111Citrate synthase; Belongs to the citrate synthase family. (454 aa)
gcvPGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (964 aa)
Sde_2572Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (637 aa)
Sde_25732-oxo-acid dehydrogenase E1 component, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (884 aa)
fabVShort-chain alcohol dehydrogenase; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (395 aa)
Sde_26562-keto-3-deoxygluconate kinase. (312 aa)
tpiA-2Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (246 aa)
Sde_2901Cysteine synthase. (317 aa)
Sde_2970Formamidase. (410 aa)
Sde_3149Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
Sde_3207Conserved hypothetical protein. (300 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (313 aa)
tpiA-3Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
Sde_3279Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (365 aa)
Sde_32802-keto-3-deoxygluconate kinase. (312 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (873 aa)
ilvAL-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (503 aa)
rpiARibose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (226 aa)
Sde_3388D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (411 aa)
Sde_3872Phosphoenolpyruvate synthase/pyruvate phosphate dikinase-like protein. (656 aa)
Your Current Organism:
Saccharophagus degradans
NCBI taxonomy Id: 203122
Other names: Microbulbifer degradans 2-40, Microbulbifer sp. 2-40, S. degradans 2-40, Saccharophagus degradans 2-40, Saccharophagus degradans ATCC 43961, Saccharophagus degradans str. 2-40, Saccharophagus degradans strain 2-40, bacterium 2-40
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