STRINGSTRING
uppS uppS TWT_560 TWT_560 TWT_559 TWT_559 TWT_558 TWT_558 TWT_557 TWT_557 ftsY ftsY secY secY TWT_524 TWT_524 lpsA lpsA TWT_509 TWT_509 TWT_507 TWT_507 TWT_486 TWT_486 TWT_485 TWT_485 rng rng obg obg lepB lepB cdsA cdsA TWT_431 TWT_431 atpB atpB atpE atpE atpF atpF atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC TWT_420 TWT_420 TWT_419 TWT_419 TWT_408 TWT_408 TWT_407 TWT_407 TWT_383 TWT_383 TWT_382 TWT_382 phoS phoS pstC pstC pstA pstA phoT phoT ctaB ctaB TWT_332 TWT_332 uppS2 uppS2 TWT_330 TWT_330 TWT_329 TWT_329 dacB dacB tatC tatC uppP uppP lgt lgt secG secG era era lepA lepA secD secD TWT_270 TWT_270 qcrB qcrB qcrA qcrA qcrC qcrC ctaE ctaE TWT_245 TWT_245 ctaD ctaD ctaC ctaC pbpB pbpB plsC plsC bioY bioY ftsE ftsE qacA qacA TWT_192 TWT_192 TWT_180 TWT_180 TWT_177 TWT_177 TWT_175 TWT_175 TWT_173 TWT_173 TWT_155 TWT_155 dppD dppD dppC dppC dppB dppB TWT_139 TWT_139 TWT_138 TWT_138 TWT_133 TWT_133 secA secA TWT_121 TWT_121 TWT_090 TWT_090 TWT_088 TWT_088 TWT_086 TWT_086 TWT_082 TWT_082 TWT_078 TWT_078 TWT_077 TWT_077 menA menA fepD fepD fepG fepG fepC fepC TWT_046 TWT_046 TWT_035 TWT_035 TWT_034 TWT_034 TWT_025 TWT_025 TWT_014 TWT_014 htpX htpX TWT_012 TWT_012 crgA crgA TWT_009 TWT_009 TWT_577 TWT_577 TWT_584 TWT_584 ftsH ftsH TWT_600 TWT_600 TWT_601 TWT_601 TWT_603 TWT_603 TWT_620 TWT_620 TWT_645 TWT_645 mscL mscL TWT_663 TWT_663 TWT_664 TWT_664 TWT_671 TWT_671 TWT_684 TWT_684 TWT_699 TWT_699 ponA ponA cycY cycY ccsA ccsA ccsB ccsB TWT_761 TWT_761 TWT_767 TWT_767 TWT_769 TWT_769 TWT_774 TWT_774 pbpA pbpA pknA pknA ndh ndh nhaA nhaA TWT_799 TWT_799 ctpA ctpA TWT_806 TWT_806
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
uppSUndecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (249 aa)
TWT_560Branched-chain amino acid ABC transporter permease protein; Belongs to the binding-protein-dependent transport system permease family. (334 aa)
TWT_559Branched-chain amino acid ABC transporter permease protein; Belongs to the binding-protein-dependent transport system permease family. (364 aa)
TWT_558Branched-chain amino acid ABC transporter ATP-binding protein. (270 aa)
TWT_557Branched-chain amino acid ABC transporter ATP-binding protein. (233 aa)
ftsYCell division protein FtsY. (222 aa)
secYPreprotein translocase SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (441 aa)
TWT_524Unknown. (193 aa)
lpsALipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. (150 aa)
TWT_509Tellurium resistence protein TerC-like protein. (317 aa)
TWT_507Acyltransferase family protein. (241 aa)
TWT_486Unknown. (207 aa)
TWT_485Unknown. (218 aa)
rngRibonuclease G. (549 aa)
obgGTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (445 aa)
lepBLeader peptidase I; Belongs to the peptidase S26 family. (230 aa)
cdsAPhosphatidate cytidylyltransferase; Belongs to the CDS family. (280 aa)
TWT_431Unknown. (145 aa)
atpBATP synthase A chain; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (271 aa)
atpEATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (75 aa)
atpFATP synthase B chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (172 aa)
atpHATP synthase delta chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (327 aa)
atpAATP synthase alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (554 aa)
atpGATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (336 aa)
atpDATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (477 aa)
atpCATP synthase epsilon chain. (94 aa)
TWT_420Cation efflux protein. (312 aa)
TWT_419Unknown. (398 aa)
TWT_408ABC transporter ATP-binding protein. (515 aa)
TWT_407Unknown. (242 aa)
TWT_383comE operon protein 3-like protein; May contain frameshift. (472 aa)
TWT_382comE operon protein 3-like protein; May contain frameshift. (278 aa)
phoSPhosphate transport system substrate-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import; Belongs to the PstS family. (356 aa)
pstCPhosphate transport system permease protein; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (299 aa)
pstAPhosphate transport system permease protein. (297 aa)
phoTPhosphate ABC transporter ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (269 aa)
ctaBProtoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (300 aa)
TWT_332Unknown. (285 aa)
uppS2Undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (258 aa)
TWT_330Sugar ABC transporter ATP-binding protein (L-arabinose/D-xylose). (518 aa)
TWT_329Sugar ABC transporter permease protein (L-arabinose/D-xylose); Belongs to the binding-protein-dependent transport system permease family. (410 aa)
dacBSerine-type D-Ala-D-Ala carboxypeptidase. (313 aa)
tatCTwin-arginine translocase TatC component; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (255 aa)
uppPUndecaprenol kinase-like protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (279 aa)
lgtPutative prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (272 aa)
secGPreprotein translocase SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (98 aa)
eraGTP-binding protein Era-like protein; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (301 aa)
lepAGTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (601 aa)
secDPreprotein translocase SecD subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (559 aa)
TWT_270Unknown. (163 aa)
qcrBUbiquinol-cytochrome c reductase cytochrome b subunit. (536 aa)
qcrAUbiquinol-cytochrome c reductase iron-sulfur subunit. (327 aa)
qcrCUbiquinol-cytochrome c reductase cytochrome c subunit. (288 aa)
ctaECytochrome c oxidase subunit III. (207 aa)
TWT_245Unknown. (139 aa)
ctaDCytochrome c oxidase subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (543 aa)
ctaCCytochrome c oxidase subunit II. (290 aa)
pbpBPenicillin-binding protein 2. (581 aa)
plsC1-acyl-sn-glycerol-3-phosphate acyltransferase. (221 aa)
bioYBiotin synthesis BioY protein. (197 aa)
ftsECell division ATP-binding protein; Part of the ABC transporter FtsEX involved in cellular division. (918 aa)
qacAMultidrug efflux protein. (390 aa)
TWT_192Unknown. (62 aa)
TWT_180Unknown. (488 aa)
TWT_177ABC transporter ATP-binding protein. (346 aa)
TWT_175ABC transporter ATP-binding protein. (220 aa)
TWT_173Unknown. (404 aa)
TWT_155Unknown; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (211 aa)
dppDDipeptide transport system ATP-binding protein; Belongs to the ABC transporter superfamily. (542 aa)
dppCDipeptide transport system permease protein. (321 aa)
dppBDipeptide transport system permease protein. (332 aa)
TWT_139ABC transporter ATP-binding protein. (237 aa)
TWT_138ABC transporter permease protein. (201 aa)
TWT_133Sporulation initiation inhibitor SOJ-like protein. (260 aa)
secAPreprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (847 aa)
TWT_121Unknown. (627 aa)
TWT_090Protein phosphatase. (254 aa)
TWT_088Membrane-associated Zn-dependent protease-like protein. (375 aa)
TWT_086Putative drug efflux protein. (377 aa)
TWT_082Unknown. (494 aa)
TWT_078Unknown. (145 aa)
TWT_077Unknown. (246 aa)
menA1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. (303 aa)
fepDIron ABC transporter permease protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (321 aa)
fepGIron ABC transporter permease protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (395 aa)
fepCIron ABC transporter ATP-binding protein. (277 aa)
TWT_046Two-component system sensor histidine kinase. (484 aa)
TWT_035ABC transporter permease protein. (297 aa)
TWT_034ABC transporter ATP-binding protein. (268 aa)
TWT_025Unknown. (153 aa)
TWT_014Unknown. (123 aa)
htpXPutative protease HtpX; Belongs to the peptidase M48B family. (291 aa)
TWT_012Unknown. (190 aa)
crgAUnknown; Involved in cell division; Belongs to the CrgA family. (69 aa)
TWT_009Unknown. (212 aa)
TWT_577Unknown. (194 aa)
TWT_584ABC transporter ATP-binding protein. (275 aa)
ftsHCell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. (666 aa)
TWT_600ABC transporter ATP-binding protein. (623 aa)
TWT_601ABC transporter ATP-binding protein. (589 aa)
TWT_603Unknown. (364 aa)
TWT_620Unknown. (224 aa)
TWT_645MFS family transporter (D-galactonate). (439 aa)
mscLLarge-conductance mechanosensitive channel. (207 aa)
TWT_663Iron ABC transporter ATP-binding protein. (276 aa)
TWT_664Iron ABC transporter permease protein. (284 aa)
TWT_671Unknown. (672 aa)
TWT_684Putative efflux protein. (408 aa)
TWT_699Unknown. (68 aa)
ponAPenicillin-binding protein 1. (876 aa)
cycYThiol:disulfide interchange protein. (228 aa)
ccsACytochrome c-type biogenesis protein. (228 aa)
ccsBCytochrome c-type biogenesis protein. (316 aa)
TWT_761Unknown. (104 aa)
TWT_767Unknown. (147 aa)
TWT_769Metalloendopeptidase. (688 aa)
TWT_774Unknown. (149 aa)
pbpAPenicillin-binding protein. (485 aa)
pknASerine/threonine-protein kinase. (585 aa)
ndhNADH dehydrogenase. (442 aa)
nhaASodium-proton antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. (385 aa)
TWT_799Transmembrane protein; Similar to virulence factor MviN. (518 aa)
ctpACation-transporting ATPase. (716 aa)
TWT_806Unknown; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. (92 aa)
Your Current Organism:
Tropheryma whipplei
NCBI taxonomy Id: 203267
Other names: T. whipplei str. Twist, Tropheryma whipplei Twist, Tropheryma whipplei str. Twist, Tropheryma whipplei strain Twist
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