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| | BFO_3242 | Hypothetical protein. (177 aa) |
| | BFO_0008 | Putative beta-ketoacyl-acyl-carrier-protein synthase I; Identified by match to protein family HMM PF00109; match to protein family HMM PF02801; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (408 aa) |
| | cobB | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (440 aa) |
| | murQ | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (277 aa) |
| | BFO_0054 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. (412 aa) |
| | BFO_0080 | Hypothetical protein. (422 aa) |
| | BFO_0101 | Hypothetical protein. (391 aa) |
| | BFO_0108 | Identified by match to protein family HMM PF08240. (298 aa) |
| | asnS | asparagine--tRNA ligase; Identified by match to protein family HMM PF00152; match to protein family HMM PF01336; match to protein family HMM TIGR00457. (465 aa) |
| | BFO_0128 | Ketopantoate reductase PanE/ApbA C terminal domain protein; Identified by match to protein family HMM PF08546. (132 aa) |
| | BFO_0131 | Hypothetical protein. (210 aa) |
| | BFO_0175 | AMP-binding enzyme; Identified by match to protein family HMM PF00501. (557 aa) |
| | BFO_0184 | L-asparaginase, type I; Identified by match to protein family HMM PF00710; match to protein family HMM TIGR00519. (346 aa) |
| | serC | Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (387 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa) |
| | proS | proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (494 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (273 aa) |
| | BFO_0226 | Threonine/alanine tRNA ligase second additional domain protein; Identified by match to protein family HMM PF07973. (154 aa) |
| | pgk | Phosphoglycerate kinase; Identified by match to protein family HMM PF00162; Belongs to the phosphoglycerate kinase family. (420 aa) |
| | pfp | Diphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (548 aa) |
| | BFO_0303 | Metallo-beta-lactamase domain protein; Identified by match to protein family HMM PF00753. (268 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (116 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (316 aa) |
| | BFO_0336 | Putative serine O-acetyltransferase; Identified by match to protein family HMM PF00132. (273 aa) |
| | cysK | Cysteine synthase A; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. (302 aa) |
| | BFO_0413 | Succinate CoA transferase; Identified by match to protein family HMM PF02550; match to protein family HMM TIGR03458. (497 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing), C-terminal domain protein; Catalyzes the synthesis of GMP from XMP. (506 aa) |
| | gnd | Phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (483 aa) |
| | BFO_0454 | Acyl-ACP thioesterase; Identified by match to protein family HMM PF01643. (250 aa) |
| | argH | Argininosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00838. (445 aa) |
| | tyrS | tyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (430 aa) |
| | fabHA_1 | Beta-ketoacyl-acyl-carrier-protein synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (335 aa) |
| | trpS | tryptophan--tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (330 aa) |
| | BFO_0515 | Lactate/malate dehydrogenase, NAD binding domain protein; Identified by match to protein family HMM PF00056; match to protein family HMM PF02866; Belongs to the LDH/MDH superfamily. (332 aa) |
| | BFO_0540 | Nucleotide sugar dehydrogenase; Identified by match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026. (437 aa) |
| | BFO_0545 | Hypothetical protein. (353 aa) |
| | BFO_0642 | AMP-binding enzyme; Identified by match to protein family HMM PF00501. (560 aa) |
| | BFO_0670 | Metallo-beta-lactamase domain protein; Identified by match to protein family HMM PF00753. (285 aa) |
| | BFO_0673 | Putative alginate O-acetyltransferase AlgI; Identified by match to protein family HMM PF03062; Belongs to the membrane-bound acyltransferase family. (523 aa) |
| | BFO_0694 | Identified by match to protein family HMM PF01048. (414 aa) |
| | BFO_0706 | SMP-30/Gluconolaconase/LRE-like region; Identified by match to protein family HMM PF08450. (328 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (523 aa) |
| | BFO_0717 | Amino acid kinase family; Identified by match to protein family HMM PF00696; match to protein family HMM TIGR00657; Belongs to the aspartokinase family. (443 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (386 aa) |
| | BFO_0733 | Phenylalanine and histidine ammonia-lyase; Identified by match to protein family HMM PF00221. (515 aa) |
| | alaS | alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (876 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (351 aa) |
| | hutU | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (662 aa) |
| | ftcD | Glutamate formimidoyltransferase; Identified by match to protein family HMM PF02971; match to protein family HMM PF07837; match to protein family HMM TIGR02024. (298 aa) |
| | hutI | Imidazolonepropionase; Identified by match to protein family HMM PF01979; match to protein family HMM PF07969; match to protein family HMM TIGR01224. (412 aa) |
| | hutH | Histidine ammonia-lyase; Identified by match to protein family HMM PF00221; match to protein family HMM TIGR01225. (499 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (310 aa) |
| | trpB | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (453 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (495 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (478 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa) |
| | BFO_0823 | Identified by match to protein family HMM PF00682; match to protein family HMM PF08502; Belongs to the alpha-IPM synthase/homocitrate synthase family. (526 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (357 aa) |
| | metH | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1229 aa) |
| | metA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (315 aa) |
| | pyrB | Aspartate carbamoyltransferase; Identified by match to protein family HMM PF00185; match to protein family HMM PF02729; match to protein family HMM TIGR00670; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa) |
| | BFO_0854 | Hypothetical protein. (388 aa) |
| | BFO_0913 | HAD hydrolase, family IB; Identified by match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. (197 aa) |
| | metG | methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (710 aa) |
| | aroA | Putative 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (410 aa) |
| | leuS | leucine--tRNA ligase; Identified by match to protein family HMM PF08264; match to protein family HMM PF09334; match to protein family HMM TIGR00396; Belongs to the class-I aminoacyl-tRNA synthetase family. (945 aa) |
| | BFO_0947 | AMP-binding enzyme; Identified by match to protein family HMM PF00501. (635 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (288 aa) |
| | BFO_0963 | Putative glutaconyl-CoA decarboxylase subunit gamma; Identified by match to protein family HMM PF00364. (143 aa) |
| | BFO_0965 | Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039. (517 aa) |
| | mce | methylmalonyl-CoA epimerase; Identified by match to protein family HMM PF00903; match to protein family HMM TIGR03081. (133 aa) |
| | folA | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (163 aa) |
| | asnB | Asparagine synthase (glutamine-hydrolyzing); Identified by match to protein family HMM PF00310; match to protein family HMM PF00733; match to protein family HMM TIGR01536. (605 aa) |
| | BFO_1067 | Hypothetical protein. (59 aa) |
| | fabHA_2 | Beta-ketoacyl-acyl-carrier-protein synthase III; Identified by match to protein family HMM PF08541; match to protein family HMM PF08545. (331 aa) |
| | BFO_1071 | Oxidoreductase, short chain dehydrogenase/reductase family protein; Identified by match to protein family HMM PF00106; match to protein family HMM PF01370; match to protein family HMM PF08659. (249 aa) |
| | BFO_1072 | Hypothetical protein. (76 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | fabF | Beta-ketoacyl-acyl-carrier-protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (418 aa) |
| | pfkA-2 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (336 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (148 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (609 aa) |
| | gdh | Glutamate dehydrogenase, NAD-specific; Identified by match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (444 aa) |
| | BFO_1125 | Pyruvate phosphate dikinase, PEP/pyruvate binding domain protein; Identified by match to protein family HMM PF01326. (993 aa) |
| | BFO_1132 | Beta-ketoacyl synthase, C-terminal domain protein; Identified by match to protein family HMM PF00109; match to protein family HMM PF02801; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (399 aa) |
| | BFO_1133 | Hypothetical protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (342 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa) |
| | uxaC | Glucuronate isomerase; Identified by match to protein family HMM PF02614. (468 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (336 aa) |
| | glyS | glycine--tRNA ligase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (514 aa) |
| | BFO_1238 | Hypothetical protein. (137 aa) |
| | cysS | cysteine--tRNA ligase; Identified by match to protein family HMM PF01406; match to protein family HMM PF09190; match to protein family HMM PF09334; match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family. (517 aa) |
| | fabG_1 | 3-oxoacyl-[acyl-carrier-protein] reductase; Identified by match to protein family HMM PF00106; match to protein family HMM PF08659. (241 aa) |
| | acpP-2 | Putative acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (81 aa) |
| | BFO_1312 | FabA-like domain protein; Identified by match to protein family HMM PF07977. (145 aa) |
| | BFO_1314 | Beta-ketoacyl synthase, C-terminal domain protein; Identified by match to protein family HMM PF00109; match to protein family HMM PF02801; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (390 aa) |
| | BFO_1315 | Hypothetical protein. (210 aa) |
| | BFO_1316 | Putative acyl carrier protein. (85 aa) |
| | dapB | Dihydrodipicolinate reductase; Identified by match to protein family HMM PF01113; match to protein family HMM PF05173; match to protein family HMM TIGR00036; Belongs to the DapB family. (243 aa) |
| | pruA | 1-pyrroline-5-carboxylate dehydrogenase; Identified by match to protein family HMM PF00171; match to protein family HMM TIGR01236. (543 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (461 aa) |
| | pyk | Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (481 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (139 aa) |
| | BFO_1465 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. (340 aa) |
| | abfD | Gamma-aminobutyrate metabolism dehydratase/isomerase; Identified by match to protein family HMM PF03241. (486 aa) |
| | cat | 4-hydroxybutyrate coenzyme A transferase; Identified by match to protein family HMM PF02550. (430 aa) |
| | hisS | histidine--tRNA ligase; Identified by match to protein family HMM PF00587; match to protein family HMM PF03129; match to protein family HMM TIGR00442. (453 aa) |
| | glsA | Identified by match to protein family HMM PF04960; match to protein family HMM TIGR03814; Belongs to the glutaminase family. (308 aa) |
| | BFO_1630 | Peptidase dimerization domain protein; Identified by match to protein family HMM PF01546; match to protein family HMM PF07687. (357 aa) |
| | argS | arginine--tRNA ligase; Identified by match to protein family HMM PF00750; match to protein family HMM PF03485; match to protein family HMM PF05746; match to protein family HMM TIGR00456. (596 aa) |
| | valS | valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (889 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (283 aa) |
| | BFO_1679 | Prephenate dehydrogenase; Identified by match to protein family HMM PF02153. (303 aa) |
| | BFO_1680 | Putative 3-deoxy-7-phosphoheptulonate synthase; Identified by match to protein family HMM PF00793; match to protein family HMM PF01817. (356 aa) |
| | BFO_1681 | Putative LL-diaminopimelate aminotransferase; Identified by match to protein family HMM PF00155. (392 aa) |
| | BFO_1682 | Prephenate dehydratase; Identified by match to protein family HMM PF00800. (280 aa) |
| | BFO_1687 | Cysteine desulfurase, SufS family; Identified by match to protein family HMM PF00155; match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM TIGR01979; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (400 aa) |
| | BFO_1694 | Identified by match to protein family HMM PF00117; match to protein family HMM PF01244; match to protein family HMM PF07722. (593 aa) |
| | pheS | phenylalanine--tRNA ligase, alpha subunit; Identified by match to protein family HMM PF01409; match to protein family HMM TIGR00468; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (340 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (178 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Identified by match to protein family HMM PF01288; match to protein family HMM TIGR01498. (159 aa) |
| | BFO_1782 | Hypothetical protein. (285 aa) |
| | BFO_1787 | KamA family protein. (696 aa) |
| | nagB | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (270 aa) |
| | BFO_1812 | Putative acetylornithine transaminase; Identified by match to protein family HMM PF00202; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (377 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (324 aa) |
| | BFO_1814 | Putative argininosuccinate synthase; Identified by match to protein family HMM PF00764; match to protein family HMM PF06508. (415 aa) |
| | BFO_1815 | Hypothetical protein. (216 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes. (169 aa) |
| | cobQ | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (498 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (158 aa) |
| | pheT | phenylalanine--tRNA ligase, beta subunit; Identified by match to protein family HMM PF01588; match to protein family HMM PF03147; match to protein family HMM PF03483; match to protein family HMM PF03484; match to protein family HMM TIGR00472; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (820 aa) |
| | serS | serine--tRNA ligase; Identified by match to protein family HMM PF00587; match to protein family HMM PF02403; match to protein family HMM TIGR00414. (423 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa) |
| | gltX | glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (529 aa) |
| | BFO_1954 | Putative o-succinylbenzoate synthase; Identified by match to protein family HMM PF01188. (357 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (362 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (384 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa) |
| | fabG_2 | 3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa) |
| | fabHA_3 | Beta-ketoacyl-acyl-carrier-protein synthase III; Identified by match to protein family HMM PF08541; match to protein family HMM PF08545. (314 aa) |
| | BFO_2202 | Dihydrodipicolinate synthetase family; Identified by match to protein family HMM PF00701; Belongs to the DapA family. (305 aa) |
| | BFO_2267 | Hypothetical protein. (185 aa) |
| | BFO_2278 | Oxidoreductase; Identified by match to protein family HMM PF09719; match to protein family HMM TIGR01909. (163 aa) |
| | gno | Gluconate 5-dehydrogenase; Identified by match to protein family HMM PF00106. (263 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (221 aa) |
| | asnA | Aspartate--ammonia ligase; Identified by match to protein family HMM PF03590; match to protein family HMM TIGR00669. (344 aa) |
| | folB | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (128 aa) |
| | coaBC | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (401 aa) |
| | thrS | threonine--tRNA ligase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (652 aa) |
| | BFO_2558 | Methylenetetrahydrofolate reductase (NAD(P)H); Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. (317 aa) |
| | BFO_2574 | Hypothetical protein. (123 aa) |
| | BFO_2596 | Hypothetical protein. (367 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (824 aa) |
| | tpiA | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | aspS | aspartate--tRNA ligase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (589 aa) |
| | BFO_2714 | Identified by match to protein family HMM PF02589. (193 aa) |
| | BFO_2715 | Putative iron-sulfur cluster-binding protein. (463 aa) |
| | BFO_2731 | Peptidase dimerization domain protein; Identified by match to protein family HMM PF01546; match to protein family HMM PF07687. (452 aa) |
| | BFO_2738 | Proline dehydrogenase; Identified by match to protein family HMM PF01619. (389 aa) |
| | mutA | methylmalonyl-CoA mutase, small subunit; Identified by match to protein family HMM PF01642; match to protein family HMM TIGR00642. (635 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (534 aa) |
| | BFO_2784 | Hypothetical protein. (633 aa) |
| | argF | N-acetylornithine carbamoyltransferase; Identified by match to protein family HMM PF00185; match to protein family HMM PF02729; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (320 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (255 aa) |
| | ispE | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (267 aa) |
| | glnS | glutamine--tRNA ligase; Identified by match to protein family HMM PF00749; match to protein family HMM PF03950; match to protein family HMM TIGR00440. (570 aa) |
| | gcvP | Glycine dehydrogenase; Identified by match to protein family HMM PF02347; match to protein family HMM TIGR00461; Belongs to the GcvP family. (950 aa) |
| | BFO_2868 | Metallo-beta-lactamase domain protein; Identified by match to protein family HMM PF00753. (212 aa) |
| | BFO_2923 | Putative arginine decarboxylase, pyruvoyl-dependent. (180 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (361 aa) |
| | ileS | isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1150 aa) |
| | BFO_2948 | Putative shikimate dehydrogenase; Identified by match to protein family HMM PF01488; match to protein family HMM PF08501. (247 aa) |
| | ppdK | Pyruvate, phosphate dikinase; Identified by match to protein family HMM PF00391; match to protein family HMM PF01326; match to protein family HMM PF02896; match to protein family HMM TIGR01828; Belongs to the PEP-utilizing enzyme family. (906 aa) |
| | kbl | Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (396 aa) |
| | BFO_3030 | Oxidoreductase, short chain dehydrogenase/reductase family protein; Identified by match to protein family HMM PF00106; match to protein family HMM PF01370; match to protein family HMM PF08659. (242 aa) |
| | folD | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (302 aa) |
| | BFO_3058 | O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01326. (426 aa) |
| | ilvE | Branched-chain-amino-acid transaminase; Identified by match to protein family HMM PF01063; match to protein family HMM TIGR01123. (339 aa) |
| | BFO_3153 | Homoserine dehydrogenase; Identified by match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657. (812 aa) |
| | BFO_3154 | Proposed homoserine kinase; Identified by match to protein family HMM PF01676; match to protein family HMM TIGR00306; match to protein family HMM TIGR02535. (401 aa) |
| | BFO_3175 | AMP-binding enzyme; Identified by match to protein family HMM PF00501. (551 aa) |
| | BFO_3187 | Putative 3-oxoacyl-(acyl carrier protein) synthase III; Identified by match to protein family HMM PF08541. (376 aa) |
| | BFO_3198 | Putative o-succinylbenzoate synthase; Identified by match to protein family HMM PF01188. (357 aa) |
| | BFO_3293 | FAH family protein; Identified by match to protein family HMM PF01557. (203 aa) |
| | mdsC | Mucin-desulfating sulfatase; Identified by match to protein family HMM PF01636. (362 aa) |
| | fba | Fructose-1,6-bisphosphate aldolase, class II; Identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167; match to protein family HMM TIGR01859. (353 aa) |
| | fabD | [acyl-carrier-protein] S-malonyltransferase; Identified by match to protein family HMM PF00698; match to protein family HMM TIGR00128. (293 aa) |
| | lysS | lysine--tRNA ligase; Identified by match to protein family HMM PF00152; match to protein family HMM PF01336; match to protein family HMM TIGR00499; Belongs to the class-II aminoacyl-tRNA synthetase family. (610 aa) |
| | pgi | Glucose-6-phosphate isomerase; Identified by match to protein family HMM PF00342; Belongs to the GPI family. (448 aa) |
