STRINGSTRING
pat pat AIY15752.1 AIY15752.1 AIY15754.1 AIY15754.1 AIY15755.1 AIY15755.1 AIY15950.2 AIY15950.2 asd asd serC serC dapF dapF AIY16440.2 AIY16440.2 AIY19810.3 AIY19810.3 dapD dapD AIY16872.2 AIY16872.2 hisN hisN ilvG ilvG lysA lysA AIY17057.2 AIY17057.2 AIY17058.2 AIY17058.2 thrB thrB AIY17119.2 AIY17119.2 trpD1 trpD1 hisD hisD hisC_1 hisC_1 hisB hisB hisH hisH priA_1 priA_1 hisF hisF hisI hisI trpC trpC trpB_2 trpB_2 trpA trpA hisE hisE hisG hisG AIY17392.1 AIY17392.1 ilvE_1 ilvE_1 AIY17741.1 AIY17741.1 dapA dapA AIY18059.1 AIY18059.1 leuA_2 leuA_2 leuD leuD leuC_2 leuC_2 cimA cimA ilvE_2 ilvE_2 leuB leuB AIY18350.1 AIY18350.1 ilvC ilvC ilvH ilvH ilvB ilvB ilvD ilvD dhbC dhbC AIY18710.1 AIY18710.1 ilvA ilvA AIY19024.1 AIY19024.1 AIY19093.1 AIY19093.1 leuC_1 leuC_1 AIY20192.2 AIY20192.2 AIY19599.3 AIY19599.3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
patBiosynthetic Aromatic amino acid aminotransferase alpha, Aspartate aminotransferase. (358 aa)
AIY15752.12-Amino-2-deoxy-isochorismate synthase. (641 aa)
AIY15754.1Anthranilate synthase, amidotransferase component, Para-aminobenzoate synthase, amidotransferase component. (190 aa)
AIY15755.1Para-aminobenzoate synthase, aminase component. (416 aa)
AIY15950.2Aspartokinase; Belongs to the aspartokinase family. (425 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (348 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (276 aa)
AIY16440.2Chorismate mutase I. (101 aa)
AIY19810.3N-succinyldiaminopimelate aminotransferase. (370 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (313 aa)
AIY16872.2N-succinyl-L,L-diaminopimelate desuccinylase. (365 aa)
hisNHistidinol-phosphatase [alternative form]. (298 aa)
ilvGAcetolactate synthase large subunit; Belongs to the TPP enzyme family. (553 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (464 aa)
AIY17057.2Homoserine dehydrogenase. (426 aa)
AIY17058.2Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (357 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (303 aa)
AIY17119.24-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (189 aa)
trpD1Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (440 aa)
hisC_1Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (368 aa)
hisBImidazoleglycerol-phosphate dehydratase. (202 aa)
hisHImidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (215 aa)
priA_1Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (246 aa)
hisFImidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa)
hisIPhosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (113 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (258 aa)
trpB_2Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (404 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (265 aa)
hisEPhosphoribosyl-ATP pyrophosphatase. (87 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (280 aa)
AIY17392.1Arogenate dehydrogenase. (359 aa)
ilvE_1Branched-chain amino acid aminotransferase. (350 aa)
AIY17741.1Aminodeoxychorismate lyase. (275 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (283 aa)
AIY18059.1L-threonine 3-O-phosphate decarboxylase. (331 aa)
leuA_22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (583 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
leuC_23-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa)
cimA(R)-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (535 aa)
ilvE_2Branched-chain amino acid aminotransferase. (361 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (384 aa)
AIY18350.1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (341 aa)
ilvHAcetolactate synthase small subunit. (179 aa)
ilvBAcetolactate synthase large subunit. (586 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (589 aa)
dhbCIsochorismate synthase of siderophore biosynthesis. (380 aa)
AIY18710.1Threonine synthase. (426 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (431 aa)
AIY19024.1Aspartate aminotransferase. (399 aa)
AIY19093.1Hypothetical protein. (222 aa)
leuC_13-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa)
AIY20192.2Prephenate dehydratase. (249 aa)
AIY19599.3Aminotransferase. (404 aa)
Your Current Organism:
Pimelobacter simplex
NCBI taxonomy Id: 2045
Other names: ATCC 6946, Arthrobacter simplex, CCUG 23611, CIP 82.106, Corynebacterium simplex, DSM 20130, HAMBI 90, IFO 12069, KCTC 9106, LMG 16261, LMG:16261, NBRC 12069, NCIB 8929, NCIB:8929, Nocardioides simplex, P. simplex
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.