STRINGSTRING
AJR17971.1 AJR17971.1 AIY19550.1 AIY19550.1 ribA-2 ribA-2 AIY19284.1 AIY19284.1 AIY19191.1 AIY19191.1 AIY20171.2 AIY20171.2 AIY19043.1 AIY19043.1 AIY19022.1 AIY19022.1 AIY18949.1 AIY18949.1 AIY18724.1 AIY18724.1 kbl_2 kbl_2 AIY18436.2 AIY18436.2 bioD bioD AIY18292.1 AIY18292.1 bioA bioA bioB bioB thiL thiL AJR18542.1 AJR18542.1 AIY18068.2 AIY18068.2 AIY18067.1 AIY18067.1 cobQ cobQ cobK cobK cobD cobD cobO cobO cobM cobM AIY19993.2 AIY19993.2 cobI cobI AIY18053.2 AIY18053.2 cobU_2 cobU_2 cobS cobS cobU_1 cobU_1 panB panB AIY17908.2 AIY17908.2 pdxS pdxS pdxT pdxT AJR18431.1 AJR18431.1 AIY17523.2 AIY17523.2 phnB phnB AIY17391.1 AIY17391.1 AIY17355.1 AIY17355.1 ribH_1 ribH_1 ribA ribA AIY17350.1 AIY17350.1 AIY19896.2 AIY19896.2 dxs2 dxs2 AIY17275.1 AIY17275.1 AIY17109.2 AIY17109.2 AIY17075.1 AIY17075.1 AIY16766.1 AIY16766.1 AJR18241.1 AJR18241.1 AIY16534.1 AIY16534.1 thiC thiC AIY16483.2 AIY16483.2 thiG thiG AIY16480.1 AIY16480.1 AIY16479.1 AIY16479.1 thiE_2 thiE_2 AIY16376.1 AIY16376.1 serC serC AIY16225.1 AIY16225.1 panD panD panC panC AIY16040.1 AIY16040.1 folB folB folP folP cobW cobW AIY15936.1 AIY15936.1 kbl_1 kbl_1 AIY15780.1 AIY15780.1 AIY15589.1 AIY15589.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJR17971.1Hydroxymethylpyrimidine ABC transporter, substrate-binding component. (366 aa)
AIY19550.1Hypothetical protein. (125 aa)
ribA-2GTP cyclohydrolase II. (225 aa)
AIY19284.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (344 aa)
AIY19191.1Creatinine amidohydrolase. (227 aa)
AIY20171.22-dehydropantoate 2-reductase. (362 aa)
AIY19043.1Oxidoreductase of aldo/keto reductase family, subgroup 1. (283 aa)
AIY19022.1PhnB protein. (142 aa)
AIY18949.1GlcG protein. (140 aa)
AIY18724.1Pyridoxal kinase; Belongs to the pyridoxine kinase family. (287 aa)
kbl_22-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (395 aa)
AIY18436.26,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (134 aa)
bioDDethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (226 aa)
AIY18292.18-amino-7-oxononanoate synthase. (375 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (356 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (323 aa)
AJR18542.1Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (461 aa)
AIY18068.2CobN component of cobalt chelatase involved in B12 biosynthesis. (1221 aa)
AIY18067.1Precorrin-6A synthase. (240 aa)
cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (464 aa)
cobKCobalt-precorrin-6x reductase. (243 aa)
cobDAdenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (306 aa)
cobOCobinamide adenolsyltransferase. (193 aa)
cobMCobalt-precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. (252 aa)
AIY19993.2Cobalt-precorrin-6y C5-methyltransferase. (392 aa)
cobICobalt-precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. (512 aa)
AIY18053.2Cobalt-precorrin-8x methylmutase. (232 aa)
cobU_2Adenosylcobinamide-phosphate guanylyltransferase. (176 aa)
cobSCobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (255 aa)
cobU_1Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (348 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (304 aa)
AIY17908.2Omega-amino acid--pyruvate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa)
pdxSPyridoxine biosynthesis glutamine amidotransferase, synthase subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (272 aa)
pdxTPyridoxine biosynthesis glutamine amidotransferase, glutaminase subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (198 aa)
AJR18431.1Hypothetical protein. (482 aa)
AIY17523.2Putative lyase. (137 aa)
phnBPhnB protein. (152 aa)
AIY17391.1Hypothetical protein. (134 aa)
AIY17355.1Hypothetical protein. (151 aa)
ribH_16,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (161 aa)
ribA3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. (311 aa)
AIY17350.1Riboflavin synthase eubacterial/eukaryotic. (202 aa)
AIY19896.2Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (353 aa)
dxs21-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (636 aa)
AIY17275.1FAD-dependent oxidoreductase. (439 aa)
AIY17109.2Riboflavin kinase; Belongs to the ribF family. (313 aa)
AIY17075.1ATP:Cob(I)alamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (201 aa)
AIY16766.1Additional substrate-specific component NikN of nickel ECF transporter. (114 aa)
AJR18241.1Substrate-specific component NikM of nickel ECF transporter. (229 aa)
AIY16534.1Hypothetical protein. (391 aa)
thiCHydroxymethylpyrimidine phosphate synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (554 aa)
AIY16483.2Hydroxymethylpyrimidine phosphate kinase ThiD. (345 aa)
thiGThiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (254 aa)
AIY16480.1Sulfur carrier protein ThiS, Opine oxidase subunit C. (69 aa)
AIY16479.1Glycine oxidase ThiO. (332 aa)
thiE_2Thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (196 aa)
AIY16376.1Dihydrofolate reductase. (189 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
AIY16225.1Methyltransferase. (403 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (139 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (292 aa)
AIY16040.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (189 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (135 aa)
folPDihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (291 aa)
cobWPutative metal chaperone, involved in Zn homeostasis. (341 aa)
AIY15936.1Putative metal chaperone, involved in Zn homeostasis. (354 aa)
kbl_12-amino-3-ketobutyrate coenzyme A ligase. (376 aa)
AIY15780.1Oxidoreductase of aldo/keto reductase family, subgroup 1. (269 aa)
AIY15589.1Putative quinone binding protein. (134 aa)
Your Current Organism:
Pimelobacter simplex
NCBI taxonomy Id: 2045
Other names: ATCC 6946, Arthrobacter simplex, CCUG 23611, CIP 82.106, Corynebacterium simplex, DSM 20130, HAMBI 90, IFO 12069, KCTC 9106, LMG 16261, LMG:16261, NBRC 12069, NCIB 8929, NCIB:8929, Nocardioides simplex, P. simplex
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