STRINGSTRING
AIY17889.1 AIY17889.1 AIY17292.2 AIY17292.2 nadA nadA AIY17114.1 AIY17114.1 gcpE gcpE whiB_2 whiB_2 whiB whiB AIY16866.1 AIY16866.1 AIY19807.2 AIY19807.2 dpo dpo AIY16600.2 AIY16600.2 AIY16597.1 AIY16597.1 fbiC fbiC thiC thiC AIY16476.1 AIY16476.1 miaB miaB nuoI nuoI nuoG nuoG nuoF nuoF nuoB nuoB AIY19691.2 AIY19691.2 nth nth whiB_1 whiB_1 AIY15818.1 AIY15818.1 nasA nasA AIY19255.1 AIY19255.1 leuC_1 leuC_1 fprB fprB purF purF ispH ispH whiB_3 whiB_3 AIY18427.1 AIY18427.1 AIY18426.1 AIY18426.1 bioB bioB leuC_2 leuC_2 rlmN rlmN AIY18162.1 AIY18162.1 AIY18121.1 AIY18121.1 lipA-3 lipA-3 sdaA sdaA lipA-2 lipA-2 lipA lipA rimO rimO cysH cysH AIY17803.1 AIY17803.1 moaA moaA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AIY17889.1Indolepyruvate oxidoreductase subunit IorA. (722 aa)
AIY17292.2Aconitate hydratase. (808 aa)
nadAQuinolinate synthetase nadA; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (391 aa)
AIY17114.1Formate dehydrogenase-O, major subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (702 aa)
gcpE1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (383 aa)
whiB_2WhiB-like transcription regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (84 aa)
whiBWhiB-family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (88 aa)
AIY16866.1Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (108 aa)
AIY19807.2Uracil-DNA glycosylase, family 5. (243 aa)
dpoUracil-DNA glycosylase, putative family 6. (216 aa)
AIY16600.2Formate dehydrogenase O alpha subunit, selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1092 aa)
AIY16597.1Putative formate dehydrogenase oxidoreductase protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (768 aa)
fbiC7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1. (852 aa)
thiCHydroxymethylpyrimidine phosphate synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (554 aa)
AIY16476.1Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (563 aa)
miaBtRNA-i(6)A37 methylthiotransferase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (480 aa)
nuoINADH-ubiquinone oxidoreductase chain I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (196 aa)
nuoGNADH-ubiquinone oxidoreductase chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (804 aa)
nuoFNADH-ubiquinone oxidoreductase chain F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (436 aa)
nuoBNADH-ubiquinone oxidoreductase chain B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (185 aa)
AIY19691.2A/G-specific adenine glycosylase. (293 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (238 aa)
whiB_1WhiB-type transcription regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (93 aa)
AIY15818.1Phage protein. (206 aa)
nasAAssimilatory nitrate reductase large subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (676 aa)
AIY19255.1Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits. (1173 aa)
leuC_13-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa)
fprBFerredoxin. (563 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (486 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (338 aa)
whiB_3Sporulation regulatory protein WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (84 aa)
AIY18427.14Fe-4S ferredoxin, iron-sulfur binding; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (106 aa)
AIY18426.12-oxoglutarate oxidoreductase, delta subunit, putative. (81 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (356 aa)
leuC_23-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa)
rlmNRibosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (372 aa)
AIY18162.1Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (107 aa)
AIY18121.1Putative radical SAM family enzyme in heat shock gene cluster, similarity with CPO of BS HemN-type; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (403 aa)
lipA-3Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (315 aa)
sdaAL-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (460 aa)
lipA-2Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (309 aa)
lipALipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (311 aa)
rimORibosomal protein S12p Asp88 methylthiotransferase; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (496 aa)
cysHPhosphoadenylyl-sulfate reductase [thioredoxin]; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (248 aa)
AIY17803.1Ferredoxin--sulfite reductase, actinobacterial type; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (572 aa)
moaAMolybdenum cofactor biosynthesis protein MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (330 aa)
Your Current Organism:
Pimelobacter simplex
NCBI taxonomy Id: 2045
Other names: ATCC 6946, Arthrobacter simplex, CCUG 23611, CIP 82.106, Corynebacterium simplex, DSM 20130, HAMBI 90, IFO 12069, KCTC 9106, LMG 16261, LMG:16261, NBRC 12069, NCIB 8929, NCIB:8929, Nocardioides simplex, P. simplex
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.