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acs_2 acs_2 AIY19653.1 AIY19653.1 AIY19655.2 AIY19655.2 AIY15901.1 AIY15901.1 AIY15929.2 AIY15929.2 AIY15958.1 AIY15958.1 aceE aceE korB korB AJR18097.1 AJR18097.1 AIY16271.1 AIY16271.1 AIY16495.1 AIY16495.1 AIY16546.1 AIY16546.1 eno eno AIY17162.1 AIY17162.1 AIY17163.1 AIY17163.1 pfkA1 pfkA1 AIY17235.2 AIY17235.2 AIY17356.1 AIY17356.1 pgi pgi tpiA tpiA pgk pgk gapA gapA AIY20000.2 AIY20000.2 AIY18143.1 AIY18143.1 AJR18584.1 AJR18584.1 vorA vorA AIY20058.2 AIY20058.2 lpdA lpdA AIY18546.1 AIY18546.1 AIY18631.2 AIY18631.2 AIY18754.1 AIY18754.1 gpmA gpmA AIY20112.2 AIY20112.2 AIY20114.2 AIY20114.2 AIY18833.2 AIY18833.2 korA korA AIY18842.1 AIY18842.1 fbaA fbaA AIY19115.1 AIY19115.1 AIY19116.1 AIY19116.1 pdhA pdhA AIY19122.1 AIY19122.1 AIY19177.1 AIY19177.1 AIY20174.2 AIY20174.2 pckG pckG AIY19281.1 AIY19281.1 AIY19470.1 AIY19470.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
acs_2Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (659 aa)
AIY19653.1Alcohol dehydrogenase. (344 aa)
AIY19655.2Alcohol dehydrogenase. (304 aa)
AIY15901.1Alcohol dehydrogenase. (351 aa)
AIY15929.2NADPH-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (459 aa)
AIY15958.1Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (412 aa)
aceEPyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (880 aa)
korB2-oxoglutarate oxidoreductase, beta subunit. (368 aa)
AJR18097.12-oxoglutarate oxidoreductase, alpha subunit. (655 aa)
AIY16271.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (486 aa)
AIY16495.1Fructose-1,6-bisphosphatase, GlpX type. (337 aa)
AIY16546.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (485 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
AIY17162.1Putative sugar kinase. (309 aa)
AIY17163.1Putative sugar kinase. (302 aa)
pfkA16-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa)
AIY17235.2Pyruvate kinase; Belongs to the pyruvate kinase family. (460 aa)
AIY17356.1Putative aldose-1-epimerase. (302 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (558 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (266 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (401 aa)
gapANAD-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (330 aa)
AIY20000.2Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (940 aa)
AIY18143.1Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative. (693 aa)
AJR18584.1Sulfate-transport ATP-binding protein ABC transporter CysA1. (697 aa)
vorA2-oxoglutarate oxidoreductase, alpha subunit. (368 aa)
AIY20058.22-oxoglutarate oxidoreductase, beta subunit. (271 aa)
lpdADihydrolipoamide dehydrogenase. (466 aa)
AIY18546.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (478 aa)
AIY18631.2Putative N-acetyl-glucosamine kinase 2, ROK family. (298 aa)
AIY18754.1Aldehyde dehydrogenase B; Belongs to the aldehyde dehydrogenase family. (503 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (248 aa)
AIY20112.2Alcohol dehydrogenase. (324 aa)
AIY20114.2Alcohol dehydrogenase. (359 aa)
AIY18833.2Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative. (704 aa)
korA2-oxoglutarate oxidoreductase, alpha subunit. (629 aa)
AIY18842.12-oxoglutarate oxidoreductase, beta subunit. (320 aa)
fbaAFructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (343 aa)
AIY19115.1Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (455 aa)
AIY19116.1Pyruvate dehydrogenase E1 component beta subunit. (325 aa)
pdhAPyruvate dehydrogenase E1 component alpha subunit. (377 aa)
AIY19122.1Acetyl-coenzyme A synthetase. (567 aa)
AIY19177.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (507 aa)
AIY20174.2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (491 aa)
pckGPhosphoenolpyruvate carboxykinase [GTP]; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (606 aa)
AIY19281.1Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (423 aa)
AIY19470.1Alcohol dehydrogenase. (366 aa)
Your Current Organism:
Pimelobacter simplex
NCBI taxonomy Id: 2045
Other names: ATCC 6946, Arthrobacter simplex, CCUG 23611, CIP 82.106, Corynebacterium simplex, DSM 20130, HAMBI 90, IFO 12069, KCTC 9106, LMG 16261, LMG:16261, NBRC 12069, NCIB 8929, NCIB:8929, Nocardioides simplex, P. simplex
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