STRINGSTRING
AIY15950.2 AIY15950.2 asd asd AIY16242.1 AIY16242.1 gltA gltA AIY16582.1 AIY16582.1 AIY16865.1 AIY16865.1 ilvG ilvG AIY17292.2 AIY17292.2 argC argC argJ argJ argB argB argD argD ilvE_1 ilvE_1 AIY17589.1 AIY17589.1 AIY17741.1 AIY17741.1 leuA_2 leuA_2 leuD leuD leuC_2 leuC_2 cimA cimA ilvE_2 ilvE_2 leuB leuB ilvC ilvC ilvH ilvH ilvB ilvB ilvD ilvD AIY18877.1 AIY18877.1 AIY18954.1 AIY18954.1 leuC_1 leuC_1 AIY19599.3 AIY19599.3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AIY15950.2Aspartokinase; Belongs to the aspartokinase family. (425 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (348 aa)
AIY16242.1Citrate synthase (si); Belongs to the citrate synthase family. (367 aa)
gltACitrate synthase (si); Belongs to the citrate synthase family. (429 aa)
AIY16582.1Isocitrate dehydrogenase [NADP]; Belongs to the monomeric-type IDH family. (729 aa)
AIY16865.1GCN5-related N-acetyltransferase. (304 aa)
ilvGAcetolactate synthase large subunit; Belongs to the TPP enzyme family. (553 aa)
AIY17292.2Aconitate hydratase. (808 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (348 aa)
argJGlutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (386 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (307 aa)
argDAcetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (401 aa)
ilvE_1Branched-chain amino acid aminotransferase. (350 aa)
AIY17589.1Acetylornithine deacetylase. (440 aa)
AIY17741.1Aminodeoxychorismate lyase. (275 aa)
leuA_22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (583 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
leuC_23-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa)
cimA(R)-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (535 aa)
ilvE_2Branched-chain amino acid aminotransferase. (361 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (384 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (341 aa)
ilvHAcetolactate synthase small subunit. (179 aa)
ilvBAcetolactate synthase large subunit. (586 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (589 aa)
AIY18877.1Acetylornithine deacetylase. (446 aa)
AIY18954.1Transcriptional regulator, GntR family domain. (417 aa)
leuC_13-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa)
AIY19599.3Aminotransferase. (404 aa)
Your Current Organism:
Pimelobacter simplex
NCBI taxonomy Id: 2045
Other names: ATCC 6946, Arthrobacter simplex, CCUG 23611, CIP 82.106, Corynebacterium simplex, DSM 20130, HAMBI 90, IFO 12069, KCTC 9106, LMG 16261, LMG:16261, NBRC 12069, NCIB 8929, NCIB:8929, Nocardioides simplex, P. simplex
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