(77 nodes) Two-component system network (Pimelobacter simplex)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	dnaA	Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (540 aa)
	AIY15616.1	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
	AIY15620.1	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (407 aa)
	AIY15633.1	3-ketoacyl-CoA thiolase, acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
	AIY15659.1	3-ketoacyl-CoA thiolase, acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
	AIY15665.1	Glutamine synthetase, putative. (430 aa)
	AIY15758.1	Osmosensitive K+ channel histidine kinase KdpD. (475 aa)
	mprA	Putative two-component system response regulator. (237 aa)
	AIY15994.1	Transcriptional regulator; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase. (225 aa)
	AIY16033.1	UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (363 aa)
	AIY16315.1	Flagellar motor rotation protein MotA. (256 aa)
	cheY64H-1	Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY. (119 aa)
	AIY16329.1	Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY. (129 aa)
	AIY16330.1	Chemotaxis protein methyltransferase CheR. (280 aa)
	cheB	Chemotaxis response regulator protein-glutamate methylesterase CheB; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (356 aa)
	AIY16338.1	Flagellin protein FlaA; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (265 aa)
	AIY19731.2	RNA polymerase sigma factor for flagellar operon; Belongs to the sigma-70 factor family. (273 aa)
	AIY16343.2	Carbon storage regulator; Belongs to the CsrA/RsmA family. (66 aa)
	AIY16347.1	Signal transduction histidine kinase CheA. (721 aa)
	AIY16348.1	Positive regulator of CheA protein activity (CheW). (155 aa)
	phoD_1	Alkaline phosphatase. (558 aa)
	AIY19759.2	HtrA protease/chaperone protein. (380 aa)
	AIY16538.1	Putative Cytochrome bd2, subunit II. (336 aa)
	pstS	Putative periplasmic phosphate-binding protein PstS (Catenulisporaceae type). (532 aa)
	AIY16674.1	Putative alkaline phosphatase. (562 aa)
	AIY16746.1	TctA citrate transporter. (508 aa)
	AIY16747.1	TctB citrate transporter. (176 aa)
	AIY16748.2	TctC citrate transporter. (335 aa)
	AIY16788.2	NADP-dependent malic enzyme. (452 aa)
	AIY16797.1	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
	AIY16893.2	Periplasmic serine proteinase. (577 aa)
	AIY17040.2	NAD-dependent malic enzyme. (394 aa)
	AIY17091.1	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (399 aa)
	atoB_1	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (426 aa)
	AIY19936.2	Cytochrome oxidase assembly protein. (298 aa)
	atoB_3	acetyl-CoA acetyltransferase ltp3. (386 aa)
	AIY17642.2	acetyl-CoA-acetyltransferase, Mycobacterial subgroup fadA5; Belongs to the thiolase-like superfamily. Thiolase family. (383 aa)
	AIY17653.1	Sensor histidine kinase. (370 aa)
	AIY17654.1	Putative two-component system response regulator. (204 aa)
	atoB_2	acetyl-CoA acetyltransferase, Mycobacterial subgroup fadA6; Belongs to the thiolase-like superfamily. Thiolase family. (387 aa)
	AIY17799.1	C4-dicarboxylate-transport transmembrane protein DctA; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (464 aa)
	glnN	Glutamine synthetase type III, GlnN. (726 aa)
	glnA	Glutamine synthetase type I. (473 aa)
	cydA	Cytochrome d ubiquinol oxidase subunit I. (477 aa)
	AIY17931.1	Cytochrome d ubiquinol oxidase subunit II. (338 aa)
	AIY17955.2	Glutamine synthetase type I. (427 aa)
	AIY18015.1	Hypothetical protein. (233 aa)
	AIY18038.2	Putative two-component system response regulator. (228 aa)
	desR	Putative two-component system response regulator. (205 aa)
	AIY18099.2	Sensor histidine kinase. (376 aa)
	phoD_2	Alkaline phosphatase. (531 aa)
	glnB_1	Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. (112 aa)
	glnB_2	Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. (112 aa)
	AIY18432.1	Two component sensory transduction transcriptional regulatory protein MtrA. (235 aa)
	AIY18780.1	Putative two-component system sensor kinase. (379 aa)
	AIY18781.2	Vancomycin response regulator VanR. (222 aa)
	AIY18782.2	D-alanyl-D-alanine carboxypeptidase family. (173 aa)
	AIY18790.1	Phosphate regulon sensor protein PhoR (SphS). (403 aa)
	AIY18791.1	Phosphate regulon transcriptional regulatory protein PhoB (SphR). (225 aa)
	citE_1	Hydroxymethylglutaryl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (297 aa)
	AIY20117.2	TRAP-type C4-dicarboxylate transport system, large permease component. (502 aa)
	AIY18925.1	Phosphate ABC transporter, periplasmic phosphate-binding protein PstS; Part of the ABC transporter complex PstSACB involved in phosphate import; Belongs to the PstS family. (365 aa)
	AIY19026.1	Sensor histidine kinase. (227 aa)
	AIY19027.1	Osmosensitive K+ channel histidine kinase KdpD. (833 aa)
	kdpC	Potassium-transporting ATPase C chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (190 aa)
	kdpB	Potassium-transporting ATPase B chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (641 aa)
	kdpA	Potassium-transporting ATPase A chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (552 aa)
	AIY20152.2	Putative two-component system sensor kinase. (322 aa)
	citE_3	L-malyl-CoA/beta-methylmalyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (288 aa)
	AIY19079.2	Putative two-component system response regulator. (220 aa)
	ptpA	Low molecular weight protein tyrosine phosphatase. (172 aa)
	atoB_4	acetyl-CoA acetyltransferase, Mycobacterial subgroup fadA3; Belongs to the thiolase-like superfamily. Thiolase family. (405 aa)
	AIY19324.1	Sensor histidine kinase. (551 aa)
	AIY19325.1	Phosphate regulon transcriptional regulatory protein PhoB (SphR). (228 aa)
	AIY20224.2	D-alanyl-D-alanine dipeptidase. (193 aa)
	AIY19538.1	Sensor kinase, two-component system. (860 aa)
	AIY19583.1	Peptidase, S1C (protease Do) family. (668 aa)

Your Current Organism:

Pimelobacter simplex

NCBI taxonomy Id: 2045
Other names: ATCC 6946, Arthrobacter simplex, CCUG 23611, CIP 82.106, Corynebacterium simplex, DSM 20130, HAMBI 90, IFO 12069, KCTC 9106, LMG 16261, LMG:16261, NBRC 12069, NCIB 8929, NCIB:8929, Nocardioides simplex, P. simplex

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIY15616.1	AIY15620.1	KR76_00385	KR76_00410	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
AIY15616.1	AIY15633.1	KR76_00385	KR76_00495	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase, acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.687
AIY15616.1	AIY15659.1	KR76_00385	KR76_00680	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase, acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.645
AIY15616.1	AIY16797.1	KR76_00385	KR76_08475	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.694
AIY15616.1	AIY17091.1	KR76_00385	KR76_10655	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.688
AIY15616.1	AIY17642.2	KR76_00385	KR76_14340	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA-acetyltransferase, Mycobacterial subgroup fadA5; Belongs to the thiolase-like superfamily. Thiolase family.	0.697
AIY15616.1	atoB_1	KR76_00385	KR76_12070	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.689
AIY15616.1	atoB_2	KR76_00385	KR76_14430	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acetyltransferase, Mycobacterial subgroup fadA6; Belongs to the thiolase-like superfamily. Thiolase family.	0.677
AIY15616.1	atoB_3	KR76_00385	KR76_14285	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acetyltransferase ltp3.	0.600
AIY15616.1	atoB_4	KR76_00385	KR76_25140	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acetyltransferase, Mycobacterial subgroup fadA3; Belongs to the thiolase-like superfamily. Thiolase family.	0.691
AIY15620.1	AIY15616.1	KR76_00410	KR76_00385	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
AIY15620.1	AIY15633.1	KR76_00410	KR76_00495	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase, acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
AIY15620.1	AIY15659.1	KR76_00410	KR76_00680	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase, acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
AIY15620.1	AIY16797.1	KR76_00410	KR76_08475	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
AIY15620.1	AIY17091.1	KR76_00410	KR76_10655	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
AIY15620.1	AIY17642.2	KR76_00410	KR76_14340	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA-acetyltransferase, Mycobacterial subgroup fadA5; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
AIY15620.1	atoB_1	KR76_00410	KR76_12070	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase, Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
AIY15620.1	atoB_2	KR76_00410	KR76_14430	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acetyltransferase, Mycobacterial subgroup fadA6; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
AIY15620.1	atoB_3	KR76_00410	KR76_14285	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acetyltransferase ltp3.	0.711
AIY15620.1	atoB_4	KR76_00410	KR76_25140	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acetyltransferase, Mycobacterial subgroup fadA3; Belongs to the thiolase-like superfamily. Thiolase family.	0.600

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