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ilvC ilvC ilvN ilvN ilvB ilvB ACN98774.1 ACN98774.1 ACN99085.1 ACN99085.1 sdhA sdhA ACN99012.1 ACN99012.1 leuB leuB accA accA ACN99661.1 ACN99661.1 accB accB thrB thrB thrC_1 thrC_1 accC_1 accC_1 ACN99617.1 ACN99617.1 ACN98279.1 ACN98279.1 ACN98645.1 ACN98645.1 ACN98409.1 ACN98409.1 mdh mdh ACN98178.1 ACN98178.1 ACN98355.1 ACN98355.1 sucC sucC sucD sucD ACN98501.1 ACN98501.1 ACN99310.1 ACN99310.1 ACN98357.1 ACN98357.1 ACN99086.1 ACN99086.1 ACN98879.1 ACN98879.1 ACN99447.1 ACN99447.1 ACN98716.1 ACN98716.1 ppsA ppsA ilvE ilvE leuA leuA leuC leuC oadA oadA ilvD ilvD accD accD ACN99315.1 ACN99315.1 acsA_1 acsA_1 ACN99327.1 ACN99327.1 ACN98883.1 ACN98883.1 ACN98143.1 ACN98143.1 acnB acnB ACN98497.1 ACN98497.1 ACN98381.1 ACN98381.1 ACN99810.1 ACN99810.1 acsA_2 acsA_2 leuD leuD thrC_2 thrC_2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
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ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
ilvNAcetolactate synthase, small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. (188 aa)
ilvBAcetolactate synthase, large subunit, biosynthetic type; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118. (581 aa)
ACN98774.1Succinate dehydrogenase, subunit C; Identified by match to protein family HMM PF02754. (292 aa)
ACN99085.1Fumarate reductase, iron-sulfur subunit; Identified by match to protein family HMM PF00111; match to protein family HMM TIGR00384; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (349 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266; match to protein family HMM PF02910; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01812; match to protein family HMM TIGR01816. (568 aa)
ACN99012.1Dihydrolipoamide dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF02852; match to protein family HMM PF07992. (459 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (357 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (314 aa)
ACN99661.1Homoserine dehydrogenase (HDH); Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. (441 aa)
accBacetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (158 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (303 aa)
thrC_1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (410 aa)
accC_1acetyl-CoA carboxylase, biotin carboxylase subunit; Identified by match to protein family HMM PF00289; match to protein family HMM PF02222; match to protein family HMM PF02785; match to protein family HMM PF02786; match to protein family HMM PF08443; match to protein family HMM TIGR00514. (448 aa)
ACN99617.1Isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) (idp); Identified by match to protein family HMM PF00180. (421 aa)
ACN98279.1ATP-citrate synthase (ATP-citrate (pro-S-)-lyase)(Citrate cleavage enzyme). (435 aa)
ACN98645.1ATP-citrate synthase (ATP-citrate (pro-S-)-lyase)(Citrate cleavage enzyme); Identified by match to protein family HMM PF00549. (616 aa)
ACN98409.1Fumarate reductase iron-sulfur subunit; Identified by match to protein family HMM PF00111; match to protein family HMM TIGR00384; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (236 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (332 aa)
ACN98178.1L(+)-tartrate dehydratase subunit alpha (L-TTD alpha); Identified by match to protein family HMM PF05681; match to protein family HMM TIGR00722. (281 aa)
ACN98355.1Fumarate hydratase, class I; Identified by match to protein family HMM PF05683; match to protein family HMM TIGR00723. (187 aa)
sucCsuccinyl-CoA synthetase beta chain (SCS-alpha)(Vegetative protein 63) (VEG63); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinate-CoA ligase, alpha subunit subfamily; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
ACN98501.1Subunit of 2-oxoglutarate:ferredoxin oxidoredutase; Identified by match to protein family HMM PF01855; match to protein family HMM PF02780. (389 aa)
ACN99310.1Subunit of 2-oxoglutarate:ferredoxin oxidoredutase; Identified by match to protein family HMM PF02775. (292 aa)
ACN98357.1Subunit of 2-oxoglutarate:ferredoxin oxidoredutase; Identified by match to protein family HMM PF01558; match to protein family HMM TIGR02175. (226 aa)
ACN99086.1Conserved domain protein. (76 aa)
ACN98879.1Pyruvate:ferredoxin oxidoreductase alpha subunit; Identified by match to protein family HMM PF01855; match to protein family HMM PF02780. (398 aa)
ACN99447.1Pyruvate:ferredoxin oxidoreductase beta subunit; Identified by match to protein family HMM PF02775. (286 aa)
ACN98716.1Pyruvate:ferredoxin oxidoreductase gamma subunit; Identified by match to protein family HMM PF01558; match to protein family HMM TIGR02175. (239 aa)
ppsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (807 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (302 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (516 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (431 aa)
oadAOxaloacetate decarboxylase alpha subunit; Identified by match to protein family HMM PF00364; match to protein family HMM PF00682; match to protein family HMM PF02436; match to protein family HMM TIGR01108. (614 aa)
ilvDDihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. (557 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (278 aa)
ACN99315.1Citrate synthase 2 (Citrate synthase II); Identified by match to protein family HMM PF00285; Belongs to the citrate synthase family. (375 aa)
acsA_1acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (630 aa)
ACN99327.12-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM PF08502; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. (533 aa)
ACN98883.1citryl-CoA lyase. (255 aa)
ACN98143.1Pyruvate carboxylase (Pyruvic carboxylase) (PYC); Identified by match to protein family HMM PF00289; match to protein family HMM PF02785; match to protein family HMM PF02786; match to protein family HMM PF08443. (482 aa)
acnBAconitate hydratase 2; Identified by match to protein family HMM PF00330; match to protein family HMM PF06434; match to protein family HMM TIGR00117; Belongs to the aconitase/IPM isomerase family. (856 aa)
ACN98497.1Putative dehydrogenase complex, E1 component, alpha subunit; Identified by match to protein family HMM PF00676. (319 aa)
ACN98381.1Pyruvate dehydrogenase e1 component suBunit beta, precursor (pdhe1-b); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (333 aa)
ACN99810.1Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Identified by match to protein family HMM PF00198; match to protein family HMM PF00364. (414 aa)
acsA_2acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (632 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (165 aa)
thrC_2Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (356 aa)
Your Current Organism:
Sulfurihydrogenibium azorense
NCBI taxonomy Id: 204536
Other names: Aquificaceae bacterium Az-Fu1, S. azorense Az-Fu1, Sulfurihydrogenibium azorense Az-Fu1, Sulfurihydrogenibium azorense str. Az-Fu1, Sulfurihydrogenibium azorense strain Az-Fu1
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