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mvaB mvaB HEAR0201 HEAR0201 rpe rpe ech ech HEAR0251 HEAR0251 glcD glcD glcE glcE glcF glcF gcl gcl hyi hyi glxR glxR ttuD ttuD pyk pyk HEAR0340 HEAR0340 sucC sucC sucD sucD fbp1 fbp1 phbA phbA phbB1 phbB1 etfB etfB etfA etfA fadE fadE HEAR0648 HEAR0648 aceE aceE pdhB pdhB lpdA lpdA phaZ phaZ HEAR0804 HEAR0804 tkt tkt gap gap HEAR0851 HEAR0851 HEAR0887 HEAR0887 HEAR0919 HEAR0919 acsA acsA aidB aidB tal tal HEAR1083 HEAR1083 zwf zwf pgi pgi edd edd eda eda rpiA rpiA ackA ackA HEAR1516 HEAR1516 aceB aceB aceA aceA lldD lldD odhL odhL sucB sucB sucA sucA gltA gltA sdhB sdhB sdhA sdhA sdhD sdhD sdhC sdhC mdh mdh acnA acnA bdhA bdhA scoB scoB scoA scoA etfD etfD tpiA tpiA lctP lctP phaR phaR phbC phbC HEAR1954 HEAR1954 HEAR1957 HEAR1957 HEAR1958 HEAR1958 HEAR2086 HEAR2086 HEAR2151 HEAR2151 eno eno HEAR2340 HEAR2340 phbB2 phbB2 aptA aptA HEAR2484 HEAR2484 HEAR2485 HEAR2485 fumC fumC cbbA cbbA pgk pgk gabD gabD HEAR2723 HEAR2723 sgaA sgaA HEAR2733 HEAR2733 HEAR2834 HEAR2834 fadA fadA HEAR2837 HEAR2837 HEAR2838 HEAR2838 prs prs gpmA1 gpmA1 HEAR3118 HEAR3118 ttuC ttuC gpmA2 gpmA2 prpR prpR HEAR3266 HEAR3266 prpC prpC prpD prpD prpE prpE HEAR3327 HEAR3327 HEAR3328 HEAR3328 HEAR3329 HEAR3329 HEAR3330 HEAR3330 HEAR3332 HEAR3332 HEAR3333 HEAR3333 HEAR3352 HEAR3352 mmsA mmsA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
mvaBHydroxymethylglutaryl-CoA lyase (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (305 aa)
HEAR0201Putative Phosphoglycolate phosphatase (PGP) (gph); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (209 aa)
rpeRibulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) (PPE) (R5P3E); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa)
echEnoyl-CoA hydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
HEAR0251Putative Phosphoglycerate/bisphosphoglycerate mutase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the phosphoglycerate mutase family. (216 aa)
glcDGlycolate oxidase subunit glcD; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (500 aa)
glcEGlycolate oxidase subunit GlcE; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (350 aa)
glcFGlycolate oxidase iron-sulfur subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (410 aa)
gclGlyoxylate carboligase (Tartronate-semialdehyde synthase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TPP enzyme family. (582 aa)
hyiHydroxypyruvate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the hyi family. (259 aa)
glxR2-hydroxy-3-oxopropionate reductase (Tartronate semialdehyde reductase) (TSAR); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (295 aa)
ttuDPutative hydroxypyruvate reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (396 aa)
pykPyruvate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pyruvate kinase family. (471 aa)
HEAR0340Zinc-binding dehydrogenase superfamily (quinone oxidoreductase, NADPH dependent); Function of strongly homologous gene; enzyme. (325 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDSuccinyl-CoA ligase [ADP-forming] subunit alpha (Succinyl-CoA synthetase subunit alpha) (SCS-alpha); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa)
fbp1Fructose-1,6-bisphosphatase (D-fructose-1, 6-bisphosphate 1-phosphohydrolase) (FBPase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (334 aa)
phbAacetyl-CoA acetyltransferase (Acetoacetyl-CoA thiolase); Function of strongly homologous gene; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
phbB1Acetoacetyl-CoA reductase; Function of strongly homologous gene; enzyme. (246 aa)
etfBElectron transfer flavoprotein beta subunit; Function of homologous gene experimentally demonstrated in an other organism; carrier. (249 aa)
etfAElectron transfer flavoprotein alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; carrier. (309 aa)
fadEAcyl-CoA dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (596 aa)
HEAR0648Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the malic enzymes family. (770 aa)
aceEPyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (898 aa)
pdhBAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (455 aa)
lpdADihydrolipoyl dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (611 aa)
phaZpoly[D(-)-3-Hydroxybutyrate] depolymerase (PHB depolymerase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (411 aa)
HEAR0804Putative glyoxylate reductase (Glycolate reductase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (327 aa)
tktTransketolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the transketolase family. (668 aa)
gapGlyceraldehyde 3-phosphate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
HEAR0851Putative fumarylacetoacetate (FAA) hydrolase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (229 aa)
HEAR0887Serine-pyruvate aminotransferase; Function of strongly homologous gene; enzyme. (321 aa)
HEAR0919Putative fumarate hydratase class I, aerobic (Fumarase) (FumA-like); Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (512 aa)
acsAAcetyl-coenzyme A synthetase (Acetate--CoA ligase) (Acyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
aidBIsovaleryl CoA dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (551 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (311 aa)
HEAR1083Putative HTH-type transcriptional regulator HexR (Hex regulon repressor); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (283 aa)
zwfGlucose-6-phosphate 1-dehydrogenase (G6PD); Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (489 aa)
pgiGlucose-6-phosphate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GPI family. (549 aa)
edd6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (637 aa)
edaBifunctional KHG/KDPG aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (206 aa)
rpiARibose 5-phosphate isomerase A (Phosphoriboisomerase A) (PRI); Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (223 aa)
ackAAcetate kinase (Acetokinase); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (396 aa)
HEAR1516Putative phosphate acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (477 aa)
aceBMalate synthase A; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the malate synthase family. (532 aa)
aceAIsocitrate lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (443 aa)
lldDL-lactate dehydrogenase; Function of strongly homologous gene; enzyme. (381 aa)
odhLDihydrolipoyl dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (475 aa)
sucBDihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (414 aa)
sucA2-oxoglutarate dehydrogenase E1 component (Alpha-ketoglutarate dehydrogenase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (952 aa)
gltACitrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family. (437 aa)
sdhBSuccinate dehydrogenase (ubiquinone), Fe-S protein; Function of homologous gene experimentally demonstrated in an other organism; carrier; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (236 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit; Function of homologous gene experimentally demonstrated in an other organism; carrier; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (592 aa)
sdhDSuccinate dehydrogenase hydrophobic membrane anchor subunit; Function of strongly homologous gene; membrane component. (121 aa)
sdhCSuccinate dehydrogenase cytochrome b556 subunit (Cytochrome b-556); Function of strongly homologous gene; membrane component. (136 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
acnAAconitate hydratase (Citrate hydro-lyase) (Aconitase); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (912 aa)
bdhAD-beta-hydroxybutyrate dehydrogenase (BDH) (3-hydroxybutyrate dehydrogenase) (3-HBDH); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (264 aa)
scoB3-oxoacid CoA-transferase subunit B; Function of homologous gene experimentally demonstrated in an other organism; carrier. (210 aa)
scoA3-oxoacid CoA-transferase subunit A; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (232 aa)
etfDElectron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (562 aa)
tpiATriosephosphate isomerase (TIM) (Triose-phosphate isomerase); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa)
lctPL-lactate permease; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate; Belongs to the lactate permease family. (557 aa)
phaRPolyhydroxyalkanoate synthesis repressor PhaR; Function of strongly homologous gene; regulator. (190 aa)
phbCPolyhydroxyalkanoate synthase subunit PhaC; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (537 aa)
HEAR1954Enoyl-CoA hydratase/isomerase; Function of strongly homologous gene; enzyme. (259 aa)
HEAR1957Putative acyl dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; cell process. (151 aa)
HEAR1958Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (140 aa)
HEAR2086Putative phosphoglycolate phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (219 aa)
HEAR2151Putative aspartate transaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (407 aa)
enoEnolase (2-phosphoglycerate dehydratase) (2-phospho-D-glycerate hydro-lyase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
HEAR2340Uncharacterized protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (625 aa)
phbB2Acetoacetyl-CoA reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (240 aa)
aptAOmega-amino acid:pyruvate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (440 aa)
HEAR2484Hypothetical protein; No homology to any previously reported sequences. (58 aa)
HEAR2485Putative lactate permease; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate; Belongs to the lactate permease family. (542 aa)
fumCFumarate hydratase class II (fumarase C); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa)
cbbAFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
pgkPhosphoglycerate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the phosphoglycerate kinase family. (397 aa)
gabDSuccinate-semialdehyde dehydrogenase [NADP+] (SSDH); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (492 aa)
HEAR2723Enoyl-CoA hydratase; Function of strongly homologous gene; enzyme. (264 aa)
sgaASerine--glyoxylate aminotransferase (SGAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (405 aa)
HEAR2733Putative D-lactate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (999 aa)
HEAR2834Hypothetical protein; No homology to any previously reported sequences. (58 aa)
fadAAcetyl-CoA acyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
HEAR2837Putative bifunctionnal protein 3-hydroxyacyl-CoA dehydrogenase and dodecenoyl-CoA isomerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (799 aa)
HEAR2838Putative butyryl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (596 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa)
gpmA12,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (248 aa)
HEAR3118Enoyl-CoA hydratase; Function of strongly homologous gene; enzyme. (373 aa)
ttuCTartrate dehydrogenase/decarboxylase (TDH) (D-malate dehydrogenase [decarboxylating]); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (356 aa)
gpmA22,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (239 aa)
prpRPropionate catabolism operon regulatory protein; Function of homologous gene experimentally demonstrated in an other organism; regulator. (550 aa)
HEAR3266Putative methylisocitrate lyase (2-methylisocitrate lyase) (PrpB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (293 aa)
prpC2-methylcitrate synthase (Methylcitrate synthase) (Citrate synthase 2); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family. (382 aa)
prpD2-methyl citrate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (483 aa)
prpEPropionate--CoA ligase (Propionyl-CoA synthetase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (634 aa)
HEAR3327Succinate dehydrogenase/fumarate reductase Fe-S protein subunit; Function of strongly homologous gene; enzyme. (238 aa)
HEAR3328Putative fumarate reductase respiratory complex transmembrane subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (115 aa)
HEAR3329Putative fumarate reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (118 aa)
HEAR3330Putative fumarate dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (291 aa)
HEAR3332Putative tartrate dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (204 aa)
HEAR3333Putative succinate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (580 aa)
HEAR3352Putative dihydrolipoamide dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (477 aa)
mmsAMethylmalonate-semialdehyde dehydrogenase [acylating] (MMSDH); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (506 aa)
Your Current Organism:
Herminiimonas arsenicoxydans
NCBI taxonomy Id: 204773
Other names: CCM 7303, DSM 17148, H. arsenicoxydans, Herminiimonas arsenicoxydans Muller et al. 2006, LMG 22961, LMG:22961, strain ULPAs1
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