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HEAR0058 HEAR0058 rsmI rsmI HEAR0175 HEAR0175 HEAR0176 HEAR0176 diaA diaA HEAR0179 HEAR0179 lemA lemA HEAR0181 HEAR0181 bfr bfr exbD1 exbD1 exbB exbB HEAR0319 HEAR0319 HEAR0320 HEAR0320 HEAR0321 HEAR0321 HEAR0322 HEAR0322 pepP pepP HEAR0364 HEAR0364 HEAR0365 HEAR0365 lptD lptD surA surA pdxA pdxA ksgA ksgA HEAR0374 HEAR0374 kdsA kdsA HEAR0959 HEAR0959 HEAR1077 HEAR1077 bamB bamB lpxH lpxH bamA bamA lpxD lpxD fabZ fabZ lpxA lpxA lpxB lpxB HEAR1367 HEAR1367 HEAR1368 HEAR1368 HEAR1369 HEAR1369 HEAR1748 HEAR1748 HEAR1767 HEAR1767 comL comL HEAR2010 HEAR2010 HEAR2174 HEAR2174 HEAR2398 HEAR2398 HEAR2399 HEAR2399 HEAR2400 HEAR2400 HEAR2403 HEAR2403 tolQ tolQ HEAR2405 HEAR2405 HEAR2406 HEAR2406 tolB tolB pal pal cpoB cpoB kdsB kdsB lpxK lpxK exbD exbD HEAR2492 HEAR2492 HEAR2616 HEAR2616 HEAR2618 HEAR2618 bamE bamE HEAR2658 HEAR2658 exbD2 exbD2 HEAR2660 HEAR2660 lptE lptE HEAR2720 HEAR2720 HEAR2754 HEAR2754 HEAR2765 HEAR2765 lpxC lpxC HEAR2874 HEAR2874 cca cca HEAR2946 HEAR2946 HEAR2947 HEAR2947 HEAR2953 HEAR2953 HEAR2954 HEAR2954 sspB sspB HEAR3049 HEAR3049 HEAR3100 HEAR3100 HEAR3101 HEAR3101 HEAR3102 HEAR3102 HEAR3103 HEAR3103 kdsD kdsD HEAR3105 HEAR3105 HEAR3106 HEAR3106 lptA lptA HEAR3108 HEAR3108 HEAR3111 HEAR3111 HEAR3306 HEAR3306 HEAR3307 HEAR3307 HEAR3356 HEAR3356 HEAR3394 HEAR3394 HEAR3395 HEAR3395 HEAR3396 HEAR3396 HEAR3397 HEAR3397 piuC piuC HEAR3400 HEAR3400 HEAR3443 HEAR3443 HEAR3444 HEAR3444 HEAR3445 HEAR3445 HEAR3446 HEAR3446 HEAR3447 HEAR3447
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HEAR0058Putative TonB-dependent receptor protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative receptor. (763 aa)
rsmIConserved hypothetical protein, putative methyltransferase; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (298 aa)
HEAR0175Putative lipoprotein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; lipoprotein. (431 aa)
HEAR0176Putative endonuclease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the UPF0102 family. (126 aa)
diaADnaA initiator-associating protein DiaA; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (198 aa)
HEAR0179Conserved hypothetical protein, putative lipoprotein; Homologs of previously reported genes of unknown function. (217 aa)
lemALemA; Function of strongly homologous gene; membrane component. (196 aa)
HEAR0181Putative zinc dependent peptidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (658 aa)
bfrBacterioferritin (BFR) (Cytochrome b-557.5); Iron-storage protein. (157 aa)
exbD1Biopolymer transport protein exbD1; Function of homologous gene experimentally demonstrated in an other organism; transporter. (137 aa)
exbBBiopolymer transport exbB protein; Function of homologous gene experimentally demonstrated in an other organism; transporter. (242 aa)
HEAR0319Putative Periplasmic protein TonB; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (228 aa)
HEAR0320Putative bacterioferritin-associated ferredoxin Bfd; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (71 aa)
HEAR0321Hypothetical protein; No homology to any previously reported sequences. (106 aa)
HEAR0322Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (64 aa)
pepPXaa-Pro aminopeptidase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the peptidase M24B family. (444 aa)
HEAR0364Putative dTDP-glucose pyrophosphorylase RfbA; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (236 aa)
HEAR0365Putative phosphotransferase involved in cell wall biosynthesis; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (345 aa)
lptDPutative Organic solvent tolerance protein OstA; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. (750 aa)
surAChaperone SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (PPIase SurA) (Rotamase SurA); Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (469 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase (4-(phosphohydroxy)-L-threonine dehydrogenase); Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (344 aa)
ksgARibosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (255 aa)
HEAR0374Putative histidinol-phosphate phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (185 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase (KDO synthetase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. (280 aa)
HEAR0959Putative TonB-like receptor precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative receptor. (651 aa)
HEAR1077Putative Fe(2+) trafficking protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. (90 aa)
bamBPutative outer membrane lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (389 aa)
lpxHUDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (270 aa)
bamAPutative Bacterial surface antigen (D15); Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (799 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (350 aa)
fabZ(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase ((3R)-hydroxymyristoyl ACP dehydrase); Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (156 aa)
lpxAAcyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa)
lpxBLipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (393 aa)
HEAR1367Hypothetical protein; No homology to any previously reported sequences. (25 aa)
HEAR1368Putative TonB-dependent siderophore receptor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative receptor. (725 aa)
HEAR1369Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (424 aa)
HEAR1748Putative peptidyl-prolyl cis-trans isomerase D, ppiD-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (636 aa)
HEAR1767Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (237 aa)
comLCompetence lipoprotein ComL precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (261 aa)
HEAR2010Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (224 aa)
HEAR2174Putative lipoprotein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component. (382 aa)
HEAR2398Putative cobalamin (Vitamin B12) biosynthesis CbiX protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (125 aa)
HEAR2399Putative permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (382 aa)
HEAR2400Putative permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (347 aa)
HEAR2403Putative thioesterase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (141 aa)
tolQProtein TolQ; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (230 aa)
HEAR2405Putative biopolymer transport protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (146 aa)
HEAR2406Conserved hypothetical protein, putative TonB domain; Homologs of previously reported genes of unknown function. (291 aa)
tolBProtein TolB precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (423 aa)
palPutative peptidoglycan-associated lipoprotein precursor pal-like; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (167 aa)
cpoBConserved hypothetical protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (245 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (250 aa)
lpxKTetraacyldisaccharide 4' kinase (lipid A 4'kinase); Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (356 aa)
exbDBiopolymer transport protein; Function of strongly homologous gene; transporter. (144 aa)
HEAR2492Putative biopolymer transport protein ExbB-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (203 aa)
HEAR2616Putative peptidase family M48 protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (485 aa)
HEAR2618Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (582 aa)
bamEHypothetical protein, putative SmpA/OmlA domain; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (216 aa)
HEAR2658Putative biopolymer transport ExbB protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (230 aa)
exbD2Biopolymer transport protein (ExbD); Function of homologous gene experimentally demonstrated in an other organism; transporter. (127 aa)
HEAR2660Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (108 aa)
lptEPutative lipoprotein B; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane; Belongs to the LptE lipoprotein family. (174 aa)
HEAR2720Putative 3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase) KdtA-like; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (368 aa)
HEAR2754Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (304 aa)
HEAR2765Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (400 aa)
lpxCUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (UDP-3-O-acyl-GlcNAc deacetylase); Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (311 aa)
HEAR2874Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (199 aa)
cca2',3'-cyclic phosphodiesterase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. (414 aa)
HEAR2946Putative soluble lytic murein transglycosylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (649 aa)
HEAR2947Putative 5-formyltetrahydrofolate cyclo-ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (186 aa)
HEAR2953Putative acyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (290 aa)
HEAR2954Putative acyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (292 aa)
sspBStringent starvation protein B; Function of strongly homologous gene; phenotype. (172 aa)
HEAR3049Putative stringent starvation protein A; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (203 aa)
HEAR3100Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (508 aa)
HEAR3101Conserved hypothetical protein, putative membrane protein; Homologs of previously reported genes of unknown function. (103 aa)
HEAR3102Putative prenyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the UbiA prenyltransferase family. (504 aa)
HEAR3103Monovalent cation:H+ antiporter-2, CPA2 family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (662 aa)
kdsDArabinose 5-phosphate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the SIS family. GutQ/KpsF subfamily. (342 aa)
HEAR3105Putative 3-Deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P phosphatase) kdsC-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (179 aa)
HEAR3106Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (199 aa)
lptAConserved hypothetical protein, putative organic solvent tolerance protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. (185 aa)
HEAR3108Putative ABC-type transport system, ATPase component; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (246 aa)
HEAR3111Hypothetical protein; No homology to any previously reported sequences. (206 aa)
HEAR3306Putative exogenous ferric siderophore receptor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component. (737 aa)
HEAR3307Putative chloramphenicol resistance permease rarD-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (294 aa)
HEAR3356Hypothetical protein; No homology to any previously reported sequences. (152 aa)
HEAR3394Conserved hypothetical protein, putative membrane; Homologs of previously reported genes of unknown function. (212 aa)
HEAR3395Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (170 aa)
HEAR3396Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (285 aa)
HEAR3397Putative Thiamine biosynthesis lipoprotein ApbE-like precursor; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein. Belongs to the ApbE family. (344 aa)
piuCPKHD-type hydroxylase PiuC (Iron-uptake factor PiuC); Function of strongly homologous gene; enzyme. (225 aa)
HEAR3400TonB-dependent receptor for iron transport; Function of homologous gene experimentally demonstrated in an other organism; receptor. (759 aa)
HEAR3443Hypothetical protein; No homology to any previously reported sequences. (65 aa)
HEAR3444Hypothetical protein; No homology to any previously reported sequences. (91 aa)
HEAR3445Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (442 aa)
HEAR3446Putative regulatory lipoprotein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (450 aa)
HEAR3447TonB dependent receptor; Function of strongly homologous gene; putative receptor. (672 aa)
Your Current Organism:
Herminiimonas arsenicoxydans
NCBI taxonomy Id: 204773
Other names: CCM 7303, DSM 17148, H. arsenicoxydans, Herminiimonas arsenicoxydans Muller et al. 2006, LMG 22961, LMG:22961, strain ULPAs1
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