| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HEAR2749 | thiD | HEAR2749 | HEAR2263 | Putative phosphomethylpyrimidine kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Phosphomethylpyrimidine kinase; Function of strongly homologous gene; enzyme. | 0.917 |
| HEAR3402 | ppk | HEAR3402 | HEAR1106 | Putative polyphosphate kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Polyphosphate kinase (Polyphosphoric acid kinase) (ATP-polyphosphate phosphotransferase); Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.861 |
| adk | cmk | HEAR2487 | HEAR2575 | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Cytidylate kinase (CK) (Cytidine monophosphate kinase) (CMP kinase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.488 |
| adk | gmk | HEAR2487 | HEAR2130 | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | 0.859 |
| adk | ndk | HEAR2487 | HEAR1260 | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.948 |
| adk | pyrH | HEAR2487 | HEAR1337 | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Uridylate kinase (UK) (Uridine monophosphate kinase) (UMP kinase); Catalyzes the reversible phosphorylation of UMP to UDP. | 0.628 |
| adk | thiL | HEAR2487 | HEAR0642 | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Thiamin-monophosphate kinase (Thiamine-phosphate kinase); Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.900 |
| adk | tmk | HEAR2487 | HEAR1396 | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Thymidylate kinase (dTMP kinase); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.446 |
| cmk | adk | HEAR2575 | HEAR2487 | Cytidylate kinase (CK) (Cytidine monophosphate kinase) (CMP kinase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.488 |
| cmk | gmk | HEAR2575 | HEAR2130 | Cytidylate kinase (CK) (Cytidine monophosphate kinase) (CMP kinase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | 0.639 |
| cmk | ndk | HEAR2575 | HEAR1260 | Cytidylate kinase (CK) (Cytidine monophosphate kinase) (CMP kinase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.938 |
| cmk | pyrH | HEAR2575 | HEAR1337 | Cytidylate kinase (CK) (Cytidine monophosphate kinase) (CMP kinase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Uridylate kinase (UK) (Uridine monophosphate kinase) (UMP kinase); Catalyzes the reversible phosphorylation of UMP to UDP. | 0.609 |
| cmk | tmk | HEAR2575 | HEAR1396 | Cytidylate kinase (CK) (Cytidine monophosphate kinase) (CMP kinase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Thymidylate kinase (dTMP kinase); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.402 |
| gmk | adk | HEAR2130 | HEAR2487 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.859 |
| gmk | cmk | HEAR2130 | HEAR2575 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Cytidylate kinase (CK) (Cytidine monophosphate kinase) (CMP kinase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.639 |
| gmk | ndk | HEAR2130 | HEAR1260 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.935 |
| gmk | pyrH | HEAR2130 | HEAR1337 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Uridylate kinase (UK) (Uridine monophosphate kinase) (UMP kinase); Catalyzes the reversible phosphorylation of UMP to UDP. | 0.814 |
| gmk | tmk | HEAR2130 | HEAR1396 | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Thymidylate kinase (dTMP kinase); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.522 |
| ndk | adk | HEAR1260 | HEAR2487 | Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.948 |
| ndk | cmk | HEAR1260 | HEAR2575 | Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Cytidylate kinase (CK) (Cytidine monophosphate kinase) (CMP kinase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.938 |