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| | metF | 5,10-methylenetetrahydrofolate reductase; Function of strongly homologous gene; enzyme; Belongs to the methylenetetrahydrofolate reductase family. (283 aa) |
| | dapF | Diaminopimelate epimerase (DAP epimerase); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (283 aa) |
| | gpmA1 | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (248 aa) |
| | argB | Acetylglutamate kinase (NAG kinase) (AGK) (N-acetyl-L-glutamate 5-phosphotransferase); Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (297 aa) |
| | HEAR3000 | D-amino-acid transaminase; Function of strongly homologous gene; enzyme. (282 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (335 aa) |
| | HEAR3061 | Histidine triad (HIT) protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (124 aa) |
| | hisE | Phosphoribosyl-ATP pyrophosphatase (PRA-PH); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (113 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase (PRA-CH); Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (134 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (265 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (212 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase (IGPD); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (198 aa) |
| | hisD | Histidinol dehydrogenase (HDH); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (438 aa) |
| | hisG | ATP phosphoribosyltransferase (ATP-PRTase) (ATP-PRT); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (225 aa) |
| | gltB | Glutamate synthase [NADPH] large chain (NADPH-GOGAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (1562 aa) |
| | aroBK | Bifunctional protein [Includes: 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (554 aa) |
| | lysA | Diaminopimelate decarboxylase (DAP decarboxylase); Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (427 aa) |
| | glmS | Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (605 aa) |
| | hemD | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (260 aa) |
| | ttuC | Tartrate dehydrogenase/decarboxylase (TDH) (D-malate dehydrogenase [decarboxylating]); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (356 aa) |
| | gpmA2 | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (239 aa) |
| | HEAR3266 | Putative methylisocitrate lyase (2-methylisocitrate lyase) (PrpB); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (293 aa) |
| | prpD | 2-methyl citrate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (483 aa) |
| | prpE | Propionate--CoA ligase (Propionyl-CoA synthetase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (634 aa) |
| | icd1 | Isocitrate dehydrogenase, NAD-dependent; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (348 aa) |
| | HEAR3315 | Putative deoxygenases; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (263 aa) |
| | HEAR3336 | Altronate dehydratase (N part); Function of strongly homologous gene; enzyme. (93 aa) |
| | uxaA | Altronate dehydratase; Function of strongly homologous gene; enzyme. (389 aa) |
| | HEAR3341 | Putative dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the LDH2/MDH2 oxidoreductase family. (336 aa) |
| | HEAR3352 | Putative dihydrolipoamide dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (477 aa) |
| | HEAR3371 | Conserved hypothetical protein, putative SlyX domain; Homologs of previously reported genes of unknown function. (68 aa) |
| | ectD | Ectoine hydroxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (306 aa) |
| | ectC | L-ectoine synthase (N-acetyldiaminobutyrate dehydratase); Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (145 aa) |
| | ectA | L-2,4-diaminobutyric acid acetyltransferase (DABA acetyltransferase); Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. (178 aa) |
| | HEAR3398 | Putative oxidoreductase FAD/NAD(P)-binding, putative sulfite reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (456 aa) |
| | mtnN | 5'-Methylthioadenosine/S-adenosylhomocysteine (SAH) nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (262 aa) |
| | fdsA | NAD-dependent formate dehydrogenase alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (956 aa) |
| | HEAR3462 | Putative Asparaginase/glutaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (161 aa) |
| | icd2 | Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the monomeric-type IDH family. (742 aa) |
| | serS | Serine tRNA synthetase (Serine--tRNA ligase) (SerRS); Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (431 aa) |
| | leuA1 | 2-isopropylmalate synthase (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (553 aa) |
| | aidB | Isovaleryl CoA dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (551 aa) |
| | HEAR1054 | Putative lysine decarboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (750 aa) |
| | folA | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (162 aa) |
| | argA | Amino-acid N-acetyltransferase (N-acetylglutamate synthase) (AGS) (NAGS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the acetyltransferase family. ArgA subfamily. (436 aa) |
| | HEAR1083 | Putative HTH-type transcriptional regulator HexR (Hex regulon repressor); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (283 aa) |
| | pgi | Glucose-6-phosphate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GPI family. (549 aa) |
| | edd | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (637 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (379 aa) |
| | HEAR1103 | Putative L-asparaginase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (349 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarA family. (342 aa) |
| | carB | Carbamoyl phosphate synthase, large subunit (Carbamoyl-phosphate synthetase ammonia chain); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarB family. (1076 aa) |
| | folP | Dihydropteroate synthase (DHPS) (Dihydropteroate pyrophosphorylase); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (279 aa) |
| | HEAR1185 | Putative Beta lactamase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (323 aa) |
| | HEAR1199 | Putative fumarylacetoacetate (FAA) hydrolase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (264 aa) |
| | HEAR1203 | Putative D-lactate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (469 aa) |
| | aroC | Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (366 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (215 aa) |
| | leuB | 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase (PRAI); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpF family. (227 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (423 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (265 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (ACCase beta chain); Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa) |
| | folC | FolC bifunctional protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. (433 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa) |
| | HEAR1230 | Putative O-acetylhomoserine aminocarboxypropyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (414 aa) |
| | ilvI | Acetolactate synthase large subunit (AHAS) (Acetohydroxy-acid synthase large subunit) (ALS); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (579 aa) |
| | ilvH | Acetolactate synthase I/III small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (163 aa) |
| | ilvC | Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (425 aa) |
| | hisS | Histidine tRNA synthetase (Histidine--tRNA ligase) (HisRS); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (448 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (383 aa) |
| | cysE | Serine acetyltransferase (SAT); Function of strongly homologous gene; enzyme. (247 aa) |
| | cysS | Cysteinyl-tRNA synthetase (Cysteine--tRNA ligase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-I aminoacyl-tRNA synthetase family. (462 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (324 aa) |
| | ask | Aspartokinase (Aspartate kinase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aspartokinase family. (417 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase (SDAP); Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the transferase hexapeptide repeat family. (274 aa) |
| | dapC | N-succinyl-L,L-diaminopimelate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (413 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (391 aa) |
| | fabZ | (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase ((3R)-hydroxymyristoyl ACP dehydrase); Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (156 aa) |
| | pps | Phosphoenolpyruvate synthase (Pyruvate, water dikinase) (PEP synthase); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (812 aa) |
| | guaA | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. (539 aa) |
| | HEAR1383 | Putative alpha/beta hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (305 aa) |
| | mdcC | Malonate decarboxylase, delta subunit; Function of strongly homologous gene; enzyme. (104 aa) |
| | mdcB | Malonate decarboxylase beta subunit MdcB; Function of strongly homologous gene; enzyme. (298 aa) |
| | mdcE | Malonate decarboxylase gamma-subunit, MdcE; Function of strongly homologous gene; enzyme. (238 aa) |
| | HEAR1475 | Putative malonyl CoA-ACP transacylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (315 aa) |
| | bioF | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (388 aa) |
| | bioH | Carboxylesterase BioH (Biotin synthesis protein BioH); Function of strongly homologous gene; enzyme. (245 aa) |
| | bioC | Putative biotin synthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (260 aa) |
| | aceB | Malate synthase A; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the malate synthase family. (532 aa) |
| | aceA | Isocitrate lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (443 aa) |
| | hisC1 | Histidinol-phosphate aminotransferase (Imidazole acetol-phosphate transaminase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (355 aa) |
| | lldD | L-lactate dehydrogenase; Function of strongly homologous gene; enzyme. (381 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1336 aa) |
| | dadA2 | D-amino acid dehydrogenase, small subunit; Function of strongly homologous gene; enzyme. (414 aa) |
| | dadX | Alanine racemase, catabolic; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (348 aa) |
| | odhL | Dihydrolipoyl dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (475 aa) |
| | sucB | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (414 aa) |
| | sucA | 2-oxoglutarate dehydrogenase E1 component (Alpha-ketoglutarate dehydrogenase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (952 aa) |
| | HEAR1774 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (89 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa) |
| | acnA | Aconitate hydratase (Citrate hydro-lyase) (Aconitase); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (912 aa) |
| | metY | O-acetylhomoserine sulfhydrylase; Function of strongly homologous gene; enzyme. (427 aa) |
| | pheT | Phenylalanyl-tRNA synthetase beta chain (Phenylalanine--tRNA ligase beta chain) (PheRS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (809 aa) |
| | pheS | Phenylalanyl-tRNA synthetase alpha chain (Phenylalanine--tRNA ligase alpha chain) (PheRS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (338 aa) |
| | thrS | Threonyl-tRNA synthetase (Threonine--tRNA ligase) (ThrRS); Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (635 aa) |
| | tpiA | Triosephosphate isomerase (TIM) (Triose-phosphate isomerase); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS) (MECDP-synthase); Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (168 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (232 aa) |
| | serB | Phosphoserine phosphatase (PSP) (O-phosphoserine phosphohydrolase) (PSPase); Function of strongly homologous gene; enzyme. (281 aa) |
| | HEAR1919 | Cystathionine beta-lyase; Function of strongly homologous gene; enzyme. (388 aa) |
| | HEAR1954 | Enoyl-CoA hydratase/isomerase; Function of strongly homologous gene; enzyme. (259 aa) |
| | HEAR1955 | Putative phosphoglycerate mutase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (234 aa) |
| | HEAR1957 | Putative acyl dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; cell process. (151 aa) |
| | acpS | Holo-[acyl-carrier-protein] synthase (CoA:apo-[acyl-carrier-protein] pantetheinephosphotransferase); Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (130 aa) |
| | fabF1 | 3-oxoacyl-[acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa) |
| | acpP | Acyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (80 aa) |
| | fabD1 | malonyl-CoA-[acyl-carrier-protein] transacylase (MCT); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (310 aa) |
| | fabH1 | 3-oxoacyl-[acyl-carrier-protein] synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (328 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (357 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (773 aa) |
| | putA | Bifunctional protein putA: Proline dehydrogenase (Proline oxidase); Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1224 aa) |
| | thrC | Threonine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (486 aa) |
| | hom | Homoserine dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (437 aa) |
| | HEAR2173 | Putative metallo-hydrolase/oxidoreductase superfamily protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (261 aa) |
| | dapA | Dihydrodipicolinate synthase (DHDPS); Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | trpS | Tryptophanyl-tRNA synthetase (Tryptophan--tRNA ligase) (TrpRS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-I aminoacyl-tRNA synthetase family. (400 aa) |
| | eno | Enolase (2-phosphoglycerate dehydratase) (2-phospho-D-glycerate hydro-lyase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | pyrG | CTP synthase (UTP--ammonia ligase) (CTP synthetase); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (552 aa) |
| | lysS | Lysyl-tRNA synthetase (Lysine--tRNA ligase) (LysRS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-II aminoacyl-tRNA synthetase family. (511 aa) |
| | aspC | Aspartate aminotransferase (Transaminase A) (AspAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (404 aa) |
| | gloB | Putative hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) GloB-like; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (259 aa) |
| | fabI | Enoyl-[acyl-carrier-protein] reductase [NADH] (NADH-dependent enoyl-ACP reductase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (261 aa) |
| | glyA | Serine hydroxymethyltransferase (Serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (414 aa) |
| | cysI | Sulfite reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (564 aa) |
| | cysH | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. (242 aa) |
| | aptA | Omega-amino acid:pyruvate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (440 aa) |
| | HEAR2458 | Putative acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (157 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (314 aa) |
| | fumC | Fumarate hydratase class II (fumarase C); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa) |
| | cysM | Cysteine synthase B (O-acetylserine sulfhydrylase) (O-acetylserine (Thiol)-lyase B) (CSase B); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (442 aa) |
| | tyrA | Prephenate dehydrogenase (PDH); Function of strongly homologous gene; enzyme. (300 aa) |
| | hisC2 | Histidinol-phosphate aminotransferase (Imidazole acetol-phosphate transaminase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (368 aa) |
| | pheA | Bifunctional P-protein [Includes: Chorismate mutase (CM); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (358 aa) |
| | serC | Phosphoserine aminotransferase (Phosphohydroxythreonine aminotransferase) (PSAT); Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (363 aa) |
| | cbbA | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | pgk | Phosphoglycerate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the phosphoglycerate kinase family. (397 aa) |
| | ilvE | Branched-chain-amino-acid aminotransferase (BCAT); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (306 aa) |
| | folK | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; Function of strongly homologous gene; enzyme. (162 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase (Ketopantoate hydroxymethyltransferase) (KPHMT); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (276 aa) |
| | HEAR2642 | Putative chorismate mutase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (97 aa) |
| | dapB | Dihydrodipicolinate reductase (DHPR); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (268 aa) |
| | leuS | Leucyl-tRNA synthetase (Leucine--tRNA ligase) (LeuRS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-I aminoacyl-tRNA synthetase family. (881 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (421 aa) |
| | HEAR2678 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (233 aa) |
| | HEAR2724 | Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (380 aa) |
| | HEAR2733 | Putative D-lactate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (999 aa) |
| | pyrB | Aspartate carbamoyltransferase (Aspartate transcarbamylase) (ATCase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (319 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (273 aa) |
| | ubiC | Putative chorismate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (193 aa) |
| | aroQ | 3-dehydroquinate dehydratase (3-dehydroquinase) (Type II DHQase); Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (145 aa) |
| | accB | Biotin carboxyl carrier protein of acetyl-CoA carboxylase (BCCP); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (153 aa) |
| | accC | Biotin carboxylase (Acetyl-CoA carboxylase subunit A) (ACC); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (456 aa) |
| | proS | Prolyl-tRNA synthetase (Proline--tRNA ligase) (ProRS) (Global RNA synthesis factor); Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other a [...] (577 aa) |
| | proB | Glutamate 5-kinase (Gamma-glutamyl kinase) (GK); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (372 aa) |
| | ppc | Phosphoenolpyruvate carboxylase (PEPCase) (PEPC); Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (944 aa) |
| | argH | Argininosuccinate lyase (Arginosuccinase) (ASAL); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (464 aa) |
| | gltX | Glutamyl-tRNA synthetase (Glutamate--tRNA ligase) (GluRS); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (467 aa) |
| | metG | Methionine tRNA synthetase (Methionine--tRNA ligase) (MetRS); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (710 aa) |
| | panC | Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate-activating enzyme); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (279 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (486 aa) |
| | HEAR0968 | Putative threonine-phosphate decarboxylase (L-threonine-O-3-phosphate decarboxylase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (332 aa) |
| | cbiA | Putative Cobyrinic acid a,c-diamide synthase CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (438 aa) |
| | HEAR0956 | Putative phosphoglycerate mutase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (184 aa) |
| | glnA | Glutamine synthetase (Glutamate--ammonia ligase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (469 aa) |
| | acsA | Acetyl-coenzyme A synthetase (Acetate--CoA ligase) (Acyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa) |
| | HEAR0913 | Hypothetical protein; No homology to any previously reported sequences. (96 aa) |
| | argF | Ornithine carbamoyltransferase (OTCase); Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (304 aa) |
| | argG | Argininosuccinate synthetase (Citrulline--aspartate ligase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (445 aa) |
| | aroG | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (354 aa) |
| | HEAR0851 | Putative fumarylacetoacetate (FAA) hydrolase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (229 aa) |
| | ileS | Isoleucine tRNA synthetase (Isoleucine--tRNA ligase) (IleRS); Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (959 aa) |
| | coaB | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (396 aa) |
| | selD | Selenide, water dikinase (Selenophosphate synthetase) (Selenium donor protein); Synthesizes selenophosphate from selenide and ATP. (351 aa) |
| | HEAR0809 | Conserved hypothetical protein, putative membrane protein; Homologs of previously reported genes of unknown function. (283 aa) |
| | HEAR0806 | Acyl-CoA-binding protein (ACBP); Function of homologous gene experimentally demonstrated in an other organism; carrier. (84 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (212 aa) |
| | leuC2 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa) |
| | dehH | Haloacetate dehalogenase; Function of strongly homologous gene; enzyme. (308 aa) |
| | aspA | Aspartate ammonia-lyase (Aspartase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (466 aa) |
| | argD | Acetylornithine aminotransferase (ACOAT); Function of strongly homologous gene; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (400 aa) |
| | pdhB | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (455 aa) |
| | aceE | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (898 aa) |
| | folD | Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa) |
| | dadA1 | D-amino acid dehydrogenase small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (443 aa) |
| | ilvD | Dihydroxy-acid dehydratase (DAD) (2,3-dihydroxy acid hydrolyase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the IlvD/Edd family. (557 aa) |
| | HEAR0722 | Putative O-acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (176 aa) |
| | argC2 | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (310 aa) |
| | fadE | Acyl-CoA dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (596 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (869 aa) |
| | glnS | Glutamine tRNA synthetase (Glutamine--tRNA ligase) (GlnRS); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (582 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase (KDO synthetase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. (280 aa) |
| | gluQ | Glutamyl-Q tRNA(Asp) synthetase (Glu-Q-RSs); Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (319 aa) |
| | HEAR0436 | Putative anthranilate phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (331 aa) |
| | HEAR0400 | Putative metal dependent amidohydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (581 aa) |
| | gdhA | Glutamate dehydrogenase, NADP-specific (NADP-GDH); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa) |
| | glyQ | Glycine tRNA synthetase, alpha subunit (Glycine--tRNA ligase alpha chain) (GlyRS); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (305 aa) |
| | glyS | Glycine tRNA synthetase, beta subunit (Glycine--tRNA ligase beta chain) (GlyRS); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (708 aa) |
| | gloA | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (139 aa) |
| | HEAR0360 | Putative D-amino acid dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (442 aa) |
| | fdhA1 | Formate dehydrogenase, alpha subunit; Function of strongly homologous gene; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (946 aa) |
| | oxc | oxalyl-CoA decarboxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TPP enzyme family. (570 aa) |
| | abpA | 2-dehydropantoate 2-reductase (Ketopantoate reductase) (KPA reductase) (KPR); Function of strongly homologous gene; enzyme. (336 aa) |
| | HEAR0340 | Zinc-binding dehydrogenase superfamily (quinone oxidoreductase, NADPH dependent); Function of strongly homologous gene; enzyme. (325 aa) |
| | pyk | Pyruvate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pyruvate kinase family. (471 aa) |
| | gcl | Glyoxylate carboligase (Tartronate-semialdehyde synthase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TPP enzyme family. (582 aa) |
| | panD | Aspartate 1-decarboxylase alpha chain; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (119 aa) |
| | HEAR0324 | Putative glutamate synthase (NADPH); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the glutamate synthase family. (542 aa) |
| | proC | Pyrroline-5-carboxylate reductase (P5CR) (P5C reductase); Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa) |
| | glcE | Glycolate oxidase subunit GlcE; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (350 aa) |
| | glcD | Glycolate oxidase subunit glcD; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (500 aa) |
| | HEAR0273 | Putative 3-mercaptopyruvate sulfurtransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (284 aa) |
| | thrB | Homoserine kinase (HSK) (HK); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pseudomonas-type ThrB family. (322 aa) |
| | valS | Valyl-tRNA synthetase (Valine--tRNA ligase) (ValRS); Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (969 aa) |
| | HEAR0260 | Putative 2-keto-4-pentenoate hydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (280 aa) |
| | HEAR0251 | Putative Phosphoglycerate/bisphosphoglycerate mutase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the phosphoglycerate mutase family. (216 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (149 aa) |
| | tyrS | Tyrosyl-tRNA synthetase (Tyrosine--tRNA ligase) (TyrRS); Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (413 aa) |
| | anmK | Anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (379 aa) |
| | argC1 | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (345 aa) |
| | HEAR0222 | Acyl-CoA thioester hydrolase; Function of strongly homologous gene; enzyme. (138 aa) |
| | fadD | Long-chain-fatty-acid--CoA ligase (Long-chain acyl-CoA synthetase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (560 aa) |
| | HEAR0216 | Putative gluconolactonase with senescence marker; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (296 aa) |
| | HEAR0201 | Putative Phosphoglycolate phosphatase (PGP) (gph); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (209 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (498 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (345 aa) |
| | trpC | Indole-3-glycerol phosphate synthase (IGPS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpC family. (266 aa) |
| | metX | Homoserine O-acetyltransferase (Homoserine O-trans-acetylase) (Homoserine transacetylase) (HTA); Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (385 aa) |
| | HEAR0125 | Putative glutamine amidotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (255 aa) |
| | metH | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1252 aa) |
| | rocD | Ornithine aminotransferase (Ornithine--oxo-acid aminotransferase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (408 aa) |
| | mvaB | Hydroxymethylglutaryl-CoA lyase (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (305 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (339 aa) |
| | bioD | Dethiobiotin synthetase (Dethiobiotin synthase) (DTB synthetase) (DTBS); Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (250 aa) |
| | bioA | Adenosylmethionine---8-amino-7-oxononanoate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (448 aa) |
| | HEAR0098 | Putative Metallo-beta-lactamase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (354 aa) |
| | argS | Putative arginyl-tRNA synthetase (ArgS); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (577 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ alpha chain; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (411 aa) |
| | HEAR2837 | Putative bifunctionnal protein 3-hydroxyacyl-CoA dehydrogenase and dodecenoyl-CoA isomerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (799 aa) |
| | HEAR2838 | Putative butyryl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (596 aa) |
| | HEAR2843 | NUDIX hydrolase; Function of strongly homologous gene; enzyme. (172 aa) |
| | aspS | Aspartyl-tRNA synthetase (Aspartate--tRNA ligase) (AspRS); Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (599 aa) |
| | HEAR2854 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (196 aa) |
| | HEAR2859 | Conserved hypothetical protein, putative oxidoreductase; Homologs of previously reported genes of unknown function. (1332 aa) |
| | ilvA | Threonine dehydratase biosynthetic (Threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (507 aa) |
| | HEAR2863 | Putative acyl carrier protein (ACP); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (96 aa) |
| | HEAR2864 | Putative 4-coumarate--CoA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (483 aa) |
| | HEAR2865 | Conserved hypothetical protein, putative dehydratase; Homologs of previously reported genes of unknown function. (96 aa) |
| | HEAR2875 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (268 aa) |
| | HEAR2876 | 3-oxoacyl-[acyl-carrier-protein] synthase I; Function of strongly homologous gene; enzyme; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (396 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (286 aa) |
| | bioC-2 | Putative S-adenosyl-L-methionine-dependent methyltransferase; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (319 aa) |
