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HEAR0833 HEAR0833 HEAR3458 HEAR3458 fdh fdh HEAR3403 HEAR3403 HEAR3374 HEAR3374 HEAR3340 HEAR3340 HEAR0096 HEAR0096 hemA hemA HEAR0217 HEAR0217 argC1 argC1 proC proC HEAR0298 HEAR0298 pntA pntA glxR glxR HEAR0340 HEAR0340 sucD sucD abpA abpA gdhA gdhA HEAR0567 HEAR0567 qor qor phbB1 phbB1 HEAR0648 HEAR0648 argC2 argC2 epsB epsB galE1 galE1 folD folD HEAR0756 HEAR0756 HEAR0762 HEAR0762 HEAR0804 HEAR0804 ptxD ptxD HEAR3191 HEAR3191 HEAR3103 HEAR3103 gpsA gpsA ahcY ahcY fabG2 fabG2 HEAR2837 HEAR2837 aroE aroE dapB dapB tyrA tyrA ddh ddh HEAR2427 HEAR2427 HEAR2402 HEAR2402 HEAR2367 HEAR2367 phbB2 phbB2 fabI fabI hom hom fabG1 fabG1 fdhA2 fdhA2 HEAR2039 HEAR2039 HEAR1809 HEAR1809 bdhA bdhA mdh mdh HEAR1718 HEAR1718 HEAR1610 HEAR1610 dxr dxr HEAR1318 HEAR1318 ilvC ilvC asd asd HEAR1181 HEAR1181 rfbD rfbD rfbB rfbB HEAR1151 HEAR1151 galE2 galE2 HEAR1147 HEAR1147 HEAR1146 HEAR1146 HEAR1143 HEAR1143 HEAR1137 HEAR1137 rfbG rfbG HEAR1132 HEAR1132 zwf zwf HEAR1070 HEAR1070 gap gap
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HEAR0833Conserved hypothetical protein, saccharopine dehydrogenase family; Homologs of previously reported genes of unknown function. (429 aa)
HEAR3458Putative Phosphoglycerate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (327 aa)
fdhFormate dehydrogenase (NAD-dependent formate dehydrogenase) (FDH); Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (400 aa)
HEAR3403Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (150 aa)
HEAR3374Putative K+ transport system (TrkA); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter. (216 aa)
HEAR3340Putative phosphoglycerate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (317 aa)
HEAR0096Putative 3-oxoacyl-[acyl-carrier-protein] reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (259 aa)
hemAGlutamyl-tRNA reductase (GluTR); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (429 aa)
HEAR0217Putative 2-hydroxy-3-oxopropionate reductase glxR-like (Tartronate semialdehyde reductase) (TSAR); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (287 aa)
argC1N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (345 aa)
proCPyrroline-5-carboxylate reductase (P5CR) (P5C reductase); Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa)
HEAR0298Conserved hypothetical protein, putative nucleoside-diphosphate sugar epimerase; Homologs of previously reported genes of unknown function. (332 aa)
pntANAD(P) transhydrogenase subunit alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. (532 aa)
glxR2-hydroxy-3-oxopropionate reductase (Tartronate semialdehyde reductase) (TSAR); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (295 aa)
HEAR0340Zinc-binding dehydrogenase superfamily (quinone oxidoreductase, NADPH dependent); Function of strongly homologous gene; enzyme. (325 aa)
sucDSuccinyl-CoA ligase [ADP-forming] subunit alpha (Succinyl-CoA synthetase subunit alpha) (SCS-alpha); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa)
abpA2-dehydropantoate 2-reductase (Ketopantoate reductase) (KPA reductase) (KPR); Function of strongly homologous gene; enzyme. (336 aa)
gdhAGlutamate dehydrogenase, NADP-specific (NADP-GDH); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa)
HEAR0567Putative short chain dehydrogenase/reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (259 aa)
qorQuinone oxidoreductase, NADPH-dependent; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (324 aa)
phbB1Acetoacetyl-CoA reductase; Function of strongly homologous gene; enzyme. (246 aa)
HEAR0648Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the malic enzymes family. (770 aa)
argC2N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (310 aa)
epsBPolysaccharide biosynthesis glycosyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (454 aa)
galE1UDP-glucose 4-epimerase (Galactowaldenase) (UDP-galactose 4-epimerase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (339 aa)
folDBifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa)
HEAR0756Putative nucleoside-diphosphate-sugar epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (304 aa)
HEAR0762Short-chain dehydrogenase/reductase; Function of strongly homologous gene; enzyme. (249 aa)
HEAR0804Putative glyoxylate reductase (Glycolate reductase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (327 aa)
ptxDPhosphonate dehydrogenase (NAD-dependent phosphite dehydrogenase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (336 aa)
HEAR3191Putative short chain dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (259 aa)
HEAR3103Monovalent cation:H+ antiporter-2, CPA2 family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (662 aa)
gpsAGlycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (331 aa)
ahcYAdenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase); May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (479 aa)
fabG23-oxoacyl-(Acyl carrier protein) reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (239 aa)
HEAR2837Putative bifunctionnal protein 3-hydroxyacyl-CoA dehydrogenase and dodecenoyl-CoA isomerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (799 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (273 aa)
dapBDihydrodipicolinate reductase (DHPR); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (268 aa)
tyrAPrephenate dehydrogenase (PDH); Function of strongly homologous gene; enzyme. (300 aa)
ddhMeso-diaminopimelate D-dehydrogenase; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. (328 aa)
HEAR2427Putative 3-oxoacyl-[acyl-carrier-protein] reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (255 aa)
HEAR2402NADP-dependent L-serine/L-allo-threonine dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa)
HEAR2367Putative alcohol dehydrogenase (ADH)(part 1); Gene remnant; putative enzyme. (277 aa)
phbB2Acetoacetyl-CoA reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (240 aa)
fabIEnoyl-[acyl-carrier-protein] reductase [NADH] (NADH-dependent enoyl-ACP reductase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (261 aa)
homHomoserine dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (437 aa)
fabG13-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase); Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa)
fdhA2Glutathione-independent formaldehyde dehydrogenase (FDH) (FALDH); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (404 aa)
HEAR2039S-(hydroxymethyl)glutathione dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa)
HEAR1809Putative 3-oxoacyl-[acyl-carrier-protein] reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (258 aa)
bdhAD-beta-hydroxybutyrate dehydrogenase (BDH) (3-hydroxybutyrate dehydrogenase) (3-HBDH); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (264 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
HEAR1718Conserved hypothetical protein, putative NAD-dependent epimerase/dehydratase family; Homologs of previously reported genes of unknown function. (302 aa)
HEAR1610Zinc-containing alcohol dehydrogenase superfamily; Function of strongly homologous gene; enzyme. (352 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (391 aa)
HEAR1318Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (278 aa)
ilvCKetol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
asdAspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa)
HEAR1181Conserved hypothetical protein, putative xanthine dehydrogenase; Homologs of previously reported genes of unknown function. (355 aa)
rfbDdTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (293 aa)
rfbBdTDP-glucose 4,6 dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (367 aa)
HEAR1151Putative Polysaccharide biosynthesis protein CapD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (659 aa)
galE2UDP-glucose 4-epimerase (Galactowaldenase) (UDP-galactose 4-epimerase) CapN-like; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (312 aa)
HEAR1147Putative polysaccharide biosynthesis protein CapE-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (336 aa)
HEAR1146Putative dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (284 aa)
HEAR1143Conserved hypothetical proteinn putative NAD-dependent epimerase/dehydratase; Homologs of previously reported genes of unknown function. (317 aa)
HEAR1137Putative UDP-glucose 4-epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (318 aa)
rfbGCDP-glucose 4,6-dehydratase; Function of homologous gene experimentally demonstrated in an other organism; putative enzyme. (375 aa)
HEAR1132Putative UDP-glucose-4-epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (309 aa)
zwfGlucose-6-phosphate 1-dehydrogenase (G6PD); Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (489 aa)
HEAR1070S-(hydroxymethyl)glutathione dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (368 aa)
gapGlyceraldehyde 3-phosphate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
Your Current Organism:
Herminiimonas arsenicoxydans
NCBI taxonomy Id: 204773
Other names: CCM 7303, DSM 17148, H. arsenicoxydans, Herminiimonas arsenicoxydans Muller et al. 2006, LMG 22961, LMG:22961, strain ULPAs1
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