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| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (425 aa) |
| | norA | Regulator of cell morphogenesis and NO signaling; Di-iron-containing protein involved in the repair of iron- sulfur clusters; Belongs to the RIC family. (224 aa) |
| | cydA | Cytochrome bd ubiquinol oxidase subunit I; Function of homologous gene experimentally demonstrated in an other organism; carrier. (533 aa) |
| | queE | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (211 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (373 aa) |
| | mrp | Protein Mrp homolog; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (362 aa) |
| | HEAR1412 | Putative formate dehydrogenase subunit A; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (988 aa) |
| | HEAR1482 | Function of homologous gene experimentally demonstrated in an other organism; carrier. (136 aa) |
| | HEAR1546 | Putative cytochrome c, class I:Iron permease FTR1 precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (641 aa) |
| | HEAR1595 | Putative cytochrome c, class I:Iron permease FTR1 precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (648 aa) |
| | def3 | Peptide deformylase (PDF) (Polypeptide deformylase); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (177 aa) |
| | fdxA2 | Ferredoxin 1; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (109 aa) |
| | ccoP | Cytochrome c oxidase cbb3-type, subunit III; C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. (312 aa) |
| | fixO | Cytochrome c oxidase cbb3-type, monoheme subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (204 aa) |
| | fixN | Cytochrome c oxidase cbb3-type, subunit 1; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the heme-copper respiratory oxidase family. (483 aa) |
| | hemN2 | Oxygen-independent coproporphyrinogen III oxidase (Coproporphyrinogenase) (Coprogen oxidase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (485 aa) |
| | hemN1 | Oxygen-independent coproporphyrinogen III oxidase (Coproporphyrinogenase) (Coprogen oxidase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (476 aa) |
| | narG | Nitrate reductase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1242 aa) |
| | sdhB | Succinate dehydrogenase (ubiquinone), Fe-S protein; Function of homologous gene experimentally demonstrated in an other organism; carrier; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (236 aa) |
| | sdhD | Succinate dehydrogenase hydrophobic membrane anchor subunit; Function of strongly homologous gene; membrane component. (121 aa) |
| | sdhC | Succinate dehydrogenase cytochrome b556 subunit (Cytochrome b-556); Function of strongly homologous gene; membrane component. (136 aa) |
| | acnA | Aconitate hydratase (Citrate hydro-lyase) (Aconitase); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (912 aa) |
| | etfD | Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (562 aa) |
| | nuoI | NADH-quinone oxidoreductase subunit I (NADH dehydrogenase I subunit I) (NDH-1 subunit I); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (162 aa) |
| | nuoG | NADH-quinone oxidoreductase subunit G (NADH dehydrogenase I subunit G) (NDH-1 subunit G); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (777 aa) |
| | nuoF | NADH-quinone oxidoreductase subunit F (NADH dehydrogenase I subunit F) (NDH-1 subunit F); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (431 aa) |
| | nuoE | NADH-quinone oxidoreductase subunit E (NADH dehydrogenase I subunit E) (NDH-1 subunit E); Function of strongly homologous gene; enzyme. (159 aa) |
| | nuoB | NADH-quinone oxidoreductase subunit B (NADH dehydrogenase I subunit B) (NDH-1 subunit B); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity). (158 aa) |
| | rimO | Conserved hypothetical protein; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (454 aa) |
| | HEAR2124 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (414 aa) |
| | iscS | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (417 aa) |
| | fdxA3 | Ferredoxin 1; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (116 aa) |
| | cysI | Sulfite reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (564 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (314 aa) |
| | HEAR2512 | Putative cytochrome c; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (277 aa) |
| | HEAR2558 | Putative cytochrome c; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (464 aa) |
| | lapB | Conserved hypothetical protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. (391 aa) |
| | hemH | Ferrochelatase (Protoheme ferro-lyase) (Heme synthetase); Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (368 aa) |
| | fur | Ferric uptake regulation protein (Ferric uptake regulator); Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the Fur family. (140 aa) |
| | cyoB | Cytochrome o ubiquinol oxidase subunit I; Function of homologous gene experimentally demonstrated in an other organism; carrier; Belongs to the heme-copper respiratory oxidase family. (667 aa) |
| | rubA2 | Rubredoxin (Rd); Function of homologous gene experimentally demonstrated in an other organism; carrier. (64 aa) |
| | nrdB | Ribonucleoside-diphosphate reductase subunit beta (Ribonucleotide reductase small subunit); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (395 aa) |
| | HEAR2825 | Putative cytochrome c4; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (238 aa) |
| | HEAR2826 | Cytochrome c, class I precursor; Function of strongly homologous gene; carrier. (429 aa) |
| | mutY | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (391 aa) |
| | ctaD | Cytochrome c oxidase subunit 1 (Cytochrome c oxidase polypeptide I) (Cytochrome aa3 subunit 1); Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (533 aa) |
| | ctaC | Cytochrome c oxidase, subunit II (Cytochrome aa3 subunit 2); Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). (386 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (335 aa) |
| | HEAR3019 | Putative glutaredoxin-related protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier; Belongs to the glutaredoxin family. Monothiol subfamily. (104 aa) |
| | petC | Cytochrome c1 precursor; Function of strongly homologous gene; carrier. (254 aa) |
| | petB | Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (467 aa) |
| | cyaY | Frataxin-like; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (112 aa) |
| | msrQ | Conserved hypothetical protein; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, [...] (218 aa) |
| | HEAR3134 | Cytochrome c4; Function of strongly homologous gene; carrier. (221 aa) |
| | ttcA | Putative ATPase; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (318 aa) |
| | HEAR3246 | Putative cytochrome c; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (125 aa) |
| | HEAR3247 | Putative cytochrome c, class I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; carrier. (231 aa) |
| | HEAR3329 | Putative fumarate reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (118 aa) |
| | HEAR3342 | Putative molybdopterin oxidoreductase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (962 aa) |
| | HEAR3348 | Putative cytochrome c; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (181 aa) |
| | queH | Conserved hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (228 aa) |
| | piuC | PKHD-type hydroxylase PiuC (Iron-uptake factor PiuC); Function of strongly homologous gene; enzyme. (225 aa) |
| | fdsA | NAD-dependent formate dehydrogenase alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (956 aa) |
| | fdsB | NAD-dependent formate dehydrogenase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (525 aa) |
| | fdsG | NAD-dependent formate dehydrogenase gamma subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (159 aa) |
| | HEAR3445 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (442 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (339 aa) |
| | def1 | Peptide deformylase (PDF); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (176 aa) |
| | coq7 | Putative ubiquinone biosynthesis protein; Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6- methoxy-1,4-benzoquinol during ubiquinone biosynthesis. (224 aa) |
| | erpA | Iron-binding protein ErpA (Iron-sulfur cluster insertion protein); Required for insertion of 4Fe-4S clusters. (116 aa) |
| | bfr | Bacterioferritin (BFR) (Cytochrome b-557.5); Iron-storage protein. (157 aa) |
| | thiC | Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (637 aa) |
| | HEAR0357 | NADH dehydrogenase (Quinone); Function of strongly homologous gene; enzyme. (567 aa) |
| | fdhA1 | Formate dehydrogenase, alpha subunit; Function of strongly homologous gene; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (946 aa) |
| | miaB | Putative tRNA-i(6)A37 thiotransferase enzyme MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (446 aa) |
| | tsaD | Putative O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (342 aa) |
| | nasD | Nitrite reductase [NAD(P)H], large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (809 aa) |
| | HEAR0433 | Putative nitrate reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (944 aa) |
| | aoxD | Cytochrome c-552 precursor (Cytochrome c552); Function of strongly homologous gene; carrier. (105 aa) |
| | aoxB | Arsenite oxidase large subunit (AOI); Involved in the detoxification of arsenic. Oxidizes As(III)O3(3-) (arsenite) to the somewhat less toxic As(V)O4(3-) (arsenate); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (826 aa) |
| | aoxA | Arsenite oxidase small subunit precursor, Rieske type subunit, twin arginine translocation peptide; Involved in the detoxification of arsenic. Oxidizes As(III)O3(3-) (arsenite) to the somewhat less toxic As(V)O4(3-) (arsenate); Belongs to the AOX family. (173 aa) |
| | rubA1 | Rubredoxin (Rd); Function of homologous gene experimentally demonstrated in an other organism; carrier. (54 aa) |
| | hmp | Nitric oxide dioxygenase; Function of strongly homologous gene; enzyme; Belongs to the globin family. (397 aa) |
| | ilvD | Dihydroxy-acid dehydratase (DAD) (2,3-dihydroxy acid hydrolyase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the IlvD/Edd family. (557 aa) |
| | nirM | Cytochrome c-551 precursor (Cytochrome c551) (Cytochrome C8); Function of homologous gene experimentally demonstrated in an other organism; carrier. (102 aa) |
| | HEAR0755 | Putative Ferredoxin--NAD(+) reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (342 aa) |
| | leuC2 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa) |
| | HEAR0795 | Putative cytochrome c; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (123 aa) |
| | HEAR0796 | Putative cytochrome c; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (117 aa) |
| | nth | Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (216 aa) |
| | HEAR0800 | Putative electron transport complex, ferredoxin subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. (239 aa) |
| | fdxA1 | Ferredoxin-1 (Ferredoxin I) (FdI); Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (107 aa) |
| | HEAR0823 | Cytochrome c2; Function of homologous gene experimentally demonstrated in an other organism; carrier. (122 aa) |
| | HEAR0919 | Putative fumarate hydratase class I, aerobic (Fumarase) (FumA-like); Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (512 aa) |
| | HEAR1026 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (188 aa) |
| | HEAR1065 | Putative Fe-S oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (763 aa) |
| | HEAR1077 | Putative Fe(2+) trafficking protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. (90 aa) |
| | edd | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (637 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (379 aa) |
| | HEAR1115 | Putative Cytochrome c oxidase, subunit II (Cytochrome bb3 subunit 2) CoxM; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (400 aa) |
| | coxN | Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (586 aa) |
| | HEAR1156 | Putative ABC-type Fe3+ transport system, periplasmic component; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (344 aa) |
| | HEAR1183 | Putative metal-dependent enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (197 aa) |
| | HEAR1189 | Putative sulfite dehydrogenase cytochrome subunit SoxD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (359 aa) |
| | HEAR1193 | Putative Cytochrome c SoxA; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (265 aa) |
| | HEAR1194 | Putative cytochrome c (SoxX); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (204 aa) |
| | katA | Catalase (hydroperoxidase II); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the catalase family. (478 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa) |
| | rumA | 23S rRNA (Uracil-5-)-methyltransferase rumA (23S rRNA(M-5-U1939)-methyltransferase); Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (461 aa) |
| | rlmN | Putative Fe-S-cluster redox enzyme; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (386 aa) |
| | def2 | Peptide deformylase (PDF) (Polypeptide deformylase); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (178 aa) |
