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| | HEAR1610 | Zinc-containing alcohol dehydrogenase superfamily; Function of strongly homologous gene; enzyme. (352 aa) |
| | gyrB | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (835 aa) |
| | bioD | Dethiobiotin synthetase (Dethiobiotin synthase) (DTB synthetase) (DTBS); Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (250 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (339 aa) |
| | HEAR0106 | Putative TRAP-type C4-dicarboxylate transport system, periplasmic component DctP subunit; Part of the tripartite ATP-independent periplasmic (TRAP) transport system. (383 aa) |
| | def1 | Peptide deformylase (PDF); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (176 aa) |
| | metH | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1252 aa) |
| | ptsI | Phosphoenolpyruvate-protein phosphotransferase (Phosphotransferase system, enzyme I) (Protein I); General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (582 aa) |
| | diaA | DnaA initiator-associating protein DiaA; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (198 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (345 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (498 aa) |
| | HEAR0201 | Putative Phosphoglycolate phosphatase (PGP) (gph); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (209 aa) |
| | rpe | Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) (PPE) (R5P3E); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa) |
| | pyrC | Dihydroorotase (DHOase); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (352 aa) |
| | coq7 | Putative ubiquinone biosynthesis protein; Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6- methoxy-1,4-benzoquinol during ubiquinone biosynthesis. (224 aa) |
| | erpA | Iron-binding protein ErpA (Iron-sulfur cluster insertion protein); Required for insertion of 4Fe-4S clusters. (116 aa) |
| | ruvC | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (180 aa) |
| | thiE | Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (203 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (609 aa) |
| | tgt | Queuine tRNA-ribosyltransferase (tRNA-guanine transglycosylase) (Guanine insertion enzyme); Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowin [...] (375 aa) |
| | bfr | Bacterioferritin (BFR) (Cytochrome b-557.5); Iron-storage protein. (157 aa) |
| | thiC | Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (637 aa) |
| | sucC | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa) |
| | HEAR0357 | NADH dehydrogenase (Quinone); Function of strongly homologous gene; enzyme. (567 aa) |
| | fdhA1 | Formate dehydrogenase, alpha subunit; Function of strongly homologous gene; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (946 aa) |
| | pepP | Xaa-Pro aminopeptidase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the peptidase M24B family. (444 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase (4-(phosphohydroxy)-L-threonine dehydrogenase); Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (344 aa) |
| | gloA | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (139 aa) |
| | HEAR0374 | Putative histidinol-phosphate phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (185 aa) |
| | ybeY | Putative metal-dependent hydrolase; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (156 aa) |
| | miaB | Putative tRNA-i(6)A37 thiotransferase enzyme MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (446 aa) |
| | tsaD | Putative O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (342 aa) |
| | nasD | Nitrite reductase [NAD(P)H], large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (809 aa) |
| | HEAR0433 | Putative nitrate reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (944 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (602 aa) |
| | gluQ | Glutamyl-Q tRNA(Asp) synthetase (Glu-Q-RSs); Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (319 aa) |
| | aoxD | Cytochrome c-552 precursor (Cytochrome c552); Function of strongly homologous gene; carrier. (105 aa) |
| | aoxB | Arsenite oxidase large subunit (AOI); Involved in the detoxification of arsenic. Oxidizes As(III)O3(3-) (arsenite) to the somewhat less toxic As(V)O4(3-) (arsenate); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (826 aa) |
| | aoxA | Arsenite oxidase small subunit precursor, Rieske type subunit, twin arginine translocation peptide; Involved in the detoxification of arsenic. Oxidizes As(III)O3(3-) (arsenite) to the somewhat less toxic As(V)O4(3-) (arsenate); Belongs to the AOX family. (173 aa) |
| | cadA1 | Cadmium-transporting ATPase; Function of homologous gene experimentally demonstrated in an other organism; transporter. (742 aa) |
| | HEAR0536 | Putative Copper chaperone; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure. (83 aa) |
| | hemF | Coproporphyrinogen III oxidase, aerobic (Coproporphyrinogenase) (Coprogen oxidase); Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (325 aa) |
| | ribA | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (211 aa) |
| | fbp1 | Fructose-1,6-bisphosphatase (D-fructose-1, 6-bisphosphate 1-phosphohydrolase) (FBPase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (334 aa) |
| | sbcB | Exodeoxyribonuclease I (Exonuclease I) (DNA deoxyribophosphodiesterase) (dRPase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (477 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (869 aa) |
| | pgpA | Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (193 aa) |
| | thiL | Thiamin-monophosphate kinase (Thiamine-phosphate kinase); Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (319 aa) |
| | rubA1 | Rubredoxin (Rd); Function of homologous gene experimentally demonstrated in an other organism; carrier. (54 aa) |
| | HEAR0648 | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the malic enzymes family. (770 aa) |
| | hmp | Nitric oxide dioxygenase; Function of strongly homologous gene; enzyme; Belongs to the globin family. (397 aa) |
| | HEAR0689 | Putative DNA repair protein RadC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; cell process; Belongs to the UPF0758 family. (175 aa) |
| | ilvD | Dihydroxy-acid dehydratase (DAD) (2,3-dihydroxy acid hydrolyase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the IlvD/Edd family. (557 aa) |
| | nirM | Cytochrome c-551 precursor (Cytochrome c551) (Cytochrome C8); Function of homologous gene experimentally demonstrated in an other organism; carrier. (102 aa) |
| | prlC | Function of homologous gene experimentally demonstrated in an other organism; enzyme. (691 aa) |
| | aceE | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (898 aa) |
| | HEAR0755 | Putative Ferredoxin--NAD(+) reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (342 aa) |
| | leuC2 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa) |
| | HEAR0795 | Putative cytochrome c; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (123 aa) |
| | HEAR0796 | Putative cytochrome c; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (117 aa) |
| | nth | Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (216 aa) |
| | HEAR0800 | Putative electron transport complex, ferredoxin subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. (239 aa) |
| | fdxA1 | Ferredoxin-1 (Ferredoxin I) (FdI); Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (107 aa) |
| | HEAR0823 | Cytochrome c2; Function of homologous gene experimentally demonstrated in an other organism; carrier. (122 aa) |
| | SodC | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (176 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (149 aa) |
| | ileS | Isoleucine tRNA synthetase (Isoleucine--tRNA ligase) (IleRS); Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (959 aa) |
| | tkt | Transketolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the transketolase family. (668 aa) |
| | rsgA | Putative GTPase EngC; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (298 aa) |
| | rdoA | Protein RdoA; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. (330 aa) |
| | HEAR0911 | Conserved hypothetical protein, putative pyrophosphatase; Homologs of previously reported genes of unknown function. (109 aa) |
| | HEAR0919 | Putative fumarate hydratase class I, aerobic (Fumarase) (FumA-like); Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (512 aa) |
| | acsA | Acetyl-coenzyme A synthetase (Acetate--CoA ligase) (Acyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa) |
| | metG | Methionine tRNA synthetase (Methionine--tRNA ligase) (MetRS); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (710 aa) |
| | HEAR1000 | Putative TRAP dicarboxylate transporter-DctP subunit; Part of the tripartite ATP-independent periplasmic (TRAP) transport system. (373 aa) |
| | ppa | Inorganic pyrophosphatase (Pyrophosphate phospho-hydrolase) (PPase); Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. (179 aa) |
| | HEAR1026 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (188 aa) |
| | ribAB | Riboflavin biosynthesis protein ribAB [Includes: GTP cyclohydrolase-2 (GTP cyclohydrolase II); Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (370 aa) |
| | ubiD | 3-octaprenyl-4-hydroxybenzoate decarboxylase (Polyprenyl p-hydroxybenzoate decarboxylase); Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. (494 aa) |
| | recR | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa) |
| | HEAR1065 | Putative Fe-S oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (763 aa) |
| | HEAR1070 | S-(hydroxymethyl)glutathione dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (368 aa) |
| | edd | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (637 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (379 aa) |
| | ppk | Polyphosphate kinase (Polyphosphoric acid kinase) (ATP-polyphosphate phosphotransferase); Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (705 aa) |
| | HEAR1115 | Putative Cytochrome c oxidase, subunit II (Cytochrome bb3 subunit 2) CoxM; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (400 aa) |
| | coxN | Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (586 aa) |
| | rfbA | Glucose-1-phosphate thymidylyltransferase (dTDP-glucose synthase) (dTDP-glucose pyrophosphorylase); Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (301 aa) |
| | HEAR1156 | Putative ABC-type Fe3+ transport system, periplasmic component; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (344 aa) |
| | carB | Carbamoyl phosphate synthase, large subunit (Carbamoyl-phosphate synthetase ammonia chain); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarB family. (1076 aa) |
| | ftsH | Cell division protease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (635 aa) |
| | folP | Dihydropteroate synthase (DHPS) (Dihydropteroate pyrophosphorylase); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (279 aa) |
| | glmM | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (448 aa) |
| | HEAR1183 | Putative metal-dependent enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (197 aa) |
| | HEAR1189 | Putative sulfite dehydrogenase cytochrome subunit SoxD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (359 aa) |
| | HEAR1193 | Putative Cytochrome c SoxA; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (265 aa) |
| | HEAR1194 | Putative cytochrome c (SoxX); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (204 aa) |
| | katA | Catalase (hydroperoxidase II); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the catalase family. (478 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa) |
| | leuB | 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (ACCase beta chain); Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa) |
| | ilvI | Acetolactate synthase large subunit (AHAS) (Acetohydroxy-acid synthase large subunit) (ALS); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (579 aa) |
| | ilvC | Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa) |
| | surE | 5'-nucleotidase SurE (Nucleoside 5'-monophosphate phosphohydrolase); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (245 aa) |
| | rumA | 23S rRNA (Uracil-5-)-methyltransferase rumA (23S rRNA(M-5-U1939)-methyltransferase); Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (461 aa) |
| | ndk | Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | rlmN | Putative Fe-S-cluster redox enzyme; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (386 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (425 aa) |
| | hflX | GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (372 aa) |
| | purA | Adenylosuccinate synthetase (IMP--aspartate ligase) (AdSS) (AMPSase); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | lpxH | UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (270 aa) |
| | cysS | Cysteinyl-tRNA synthetase (Cysteine--tRNA ligase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-I aminoacyl-tRNA synthetase family. (462 aa) |
| | flhC | Flagellar transcriptional activator FlhC; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. (182 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase (SDAP); Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa) |
| | ligA | DNA ligase (Polydeoxyribonucleotide synthase [NAD+]); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (696 aa) |
| | def2 | Peptide deformylase (PDF) (Polypeptide deformylase); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (178 aa) |
| | map | Methionine aminopeptidase (MAP) (Peptidase M); Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (277 aa) |
| | uppS | Isoprenyl transferase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (254 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (391 aa) |
| | HEAR1342 | Putative Peptidase M50; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (455 aa) |
| | rnhB | Ribonuclease HII (RNase HII); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (211 aa) |
| | pps | Phosphoenolpyruvate synthase (Pyruvate, water dikinase) (PEP synthase); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (812 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (486 aa) |
| | norA | Regulator of cell morphogenesis and NO signaling; Di-iron-containing protein involved in the repair of iron- sulfur clusters; Belongs to the RIC family. (224 aa) |
| | azu | Azurin precursor; Transfers electrons from cytochrome c551 to cytochrome oxidase. (150 aa) |
| | cydA | Cytochrome bd ubiquinol oxidase subunit I; Function of homologous gene experimentally demonstrated in an other organism; carrier. (533 aa) |
| | queE | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (211 aa) |
| | tadA | tRNA-specific adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (170 aa) |
| | purT | Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (407 aa) |
| | moeA1 | Molybdopterin biosynthesis protein MoeA; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (438 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (198 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (373 aa) |
| | mrp | Protein Mrp homolog; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (362 aa) |
| | HEAR1412 | Putative formate dehydrogenase subunit A; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (988 aa) |
| | folE | GTP cyclohydrolase I (GTP-CH-I); Function of strongly homologous gene; enzyme. (201 aa) |
| | HEAR1482 | Function of homologous gene experimentally demonstrated in an other organism; carrier. (136 aa) |
| | ackA | Acetate kinase (Acetokinase); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (396 aa) |
| | cadA2 | Cadmium-transporting ATPase; Function of homologous gene experimentally demonstrated in an other organism; transporter. (793 aa) |
| | HEAR1546 | Putative cytochrome c, class I:Iron permease FTR1 precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (641 aa) |
| | actP | Copper transporting P-type ATPase; Function of homologous gene experimentally demonstrated in an other organism; transporter. (790 aa) |
| | cadA3 | Cadmium-transporting ATPase; Function of homologous gene experimentally demonstrated in an other organism; transporter. (744 aa) |
| | HEAR1595 | Putative cytochrome c, class I:Iron permease FTR1 precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (648 aa) |
| | HEAR1608 | P-type ATPase, copper transporting, phophatase-like domain (part 2); Function of homologous gene experimentally demonstrated in an other organism; transporter. (479 aa) |
| | cadA4 | Cadmium-transporting ATPase; Function of homologous gene experimentally demonstrated in an other organism; transporter. (767 aa) |
| | kdpB | Potassium-transporting ATPase ATP-binding subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (697 aa) |
| | def3 | Peptide deformylase (PDF) (Polypeptide deformylase); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (177 aa) |
| | fdxA2 | Ferredoxin 1; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (109 aa) |
| | ccoP | Cytochrome c oxidase cbb3-type, subunit III; C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. (312 aa) |
| | fixO | Cytochrome c oxidase cbb3-type, monoheme subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (204 aa) |
| | fixN | Cytochrome c oxidase cbb3-type, subunit 1; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the heme-copper respiratory oxidase family. (483 aa) |
| | HEAR1648 | Cation transporting P-type ATPase, probable copper-exporting copA-like; Function of strongly homologous gene; enzyme. (857 aa) |
| | hemN2 | Oxygen-independent coproporphyrinogen III oxidase (Coproporphyrinogenase) (Coprogen oxidase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (485 aa) |
| | hemN1 | Oxygen-independent coproporphyrinogen III oxidase (Coproporphyrinogenase) (Coprogen oxidase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (476 aa) |
| | narG | Nitrate reductase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1242 aa) |
| | aceA | Isocitrate lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (443 aa) |
| | selO | Conserved hypothetical protein; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). (500 aa) |
| | msrB | Peptide methionine sulfoxide reductase MsrB (Peptide-methionine (R)-S-oxide reductase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the MsrB Met sulfoxide reductase family. (137 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1336 aa) |
| | nnrD | Conserved hypothetical protein, putative carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate deh [...] (514 aa) |
| | clpX | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (422 aa) |
| | radA | DNA repair protein RadA (DNA repair protein Sms); DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (456 aa) |
| | sdhB | Succinate dehydrogenase (ubiquinone), Fe-S protein; Function of homologous gene experimentally demonstrated in an other organism; carrier; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (236 aa) |
| | sdhD | Succinate dehydrogenase hydrophobic membrane anchor subunit; Function of strongly homologous gene; membrane component. (121 aa) |
| | sdhC | Succinate dehydrogenase cytochrome b556 subunit (Cytochrome b-556); Function of strongly homologous gene; membrane component. (136 aa) |
| | HEAR1781 | Putative lyase, CitE-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the HpcH/HpaI aldolase family. (321 aa) |
| | acnA | Aconitate hydratase (Citrate hydro-lyase) (Aconitase); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (912 aa) |
| | pheT | Phenylalanyl-tRNA synthetase beta chain (Phenylalanine--tRNA ligase beta chain) (PheRS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (809 aa) |
| | pheS | Phenylalanyl-tRNA synthetase alpha chain (Phenylalanine--tRNA ligase alpha chain) (PheRS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (338 aa) |
| | thrS | Threonyl-tRNA synthetase (Threonine--tRNA ligase) (ThrRS); Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (635 aa) |
| | etfD | Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (562 aa) |
| | nuoI | NADH-quinone oxidoreductase subunit I (NADH dehydrogenase I subunit I) (NDH-1 subunit I); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (162 aa) |
| | nuoG | NADH-quinone oxidoreductase subunit G (NADH dehydrogenase I subunit G) (NDH-1 subunit G); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (777 aa) |
| | nuoF | NADH-quinone oxidoreductase subunit F (NADH dehydrogenase I subunit F) (NDH-1 subunit F); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (431 aa) |
| | nuoE | NADH-quinone oxidoreductase subunit E (NADH dehydrogenase I subunit E) (NDH-1 subunit E); Function of strongly homologous gene; enzyme. (159 aa) |
| | nuoB | NADH-quinone oxidoreductase subunit B (NADH dehydrogenase I subunit B) (NDH-1 subunit B); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity). (158 aa) |
| | pnp | Polyribonucleotide nucleotidyltransferase (Polynucleotide phosphorylase) (PNPase); Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (710 aa) |
| | HEAR1852 | Putative DNA repair protein RadC-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the UPF0758 family. (166 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS) (MECDP-synthase); Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (168 aa) |
| | rimO | Conserved hypothetical protein; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (454 aa) |
| | HEAR2039 | S-(hydroxymethyl)glutathione dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa) |
| | acpS | Holo-[acyl-carrier-protein] synthase (CoA:apo-[acyl-carrier-protein] pantetheinephosphotransferase); Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (130 aa) |
| | rnc | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (328 aa) |
| | rne | Ribonuclease E (RNase E); Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (973 aa) |
| | HEAR2124 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (414 aa) |
| | HEAR2125 | HAM1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (194 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (773 aa) |
| | moeA2 | Molybdopterin biosynthesis protein MoeA; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (417 aa) |
| | suhB | Inositol-1-monophosphatase (IMPase) (Inositol-1-phosphatase) (I-1-Pase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the inositol monophosphatase superfamily. (261 aa) |
| | htpX | Putative protease htpX (Heat shock protein htpX); Function of strongly homologous gene; putative enzyme; Belongs to the peptidase M48B family. (293 aa) |
| | eno | Enolase (2-phosphoglycerate dehydratase) (2-phospho-D-glycerate hydro-lyase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | pyrG | CTP synthase (UTP--ammonia ligase) (CTP synthetase); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (552 aa) |
| | lysS | Lysyl-tRNA synthetase (Lysine--tRNA ligase) (LysRS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-II aminoacyl-tRNA synthetase family. (511 aa) |
| | iscS | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (417 aa) |
| | dnaQ | DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (234 aa) |
| | rnhA | Ribonuclease HI (RNase HI); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (146 aa) |
| | gloB | Putative hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) GloB-like; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (259 aa) |
| | fdxA3 | Ferredoxin 1; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (116 aa) |
| | ribD | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (363 aa) |
| | nrdR | Transcriptional repressor NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (156 aa) |
| | cysI | Sulfite reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (564 aa) |
| | pepA | Cytosol aminopeptidase (Leucine aminopeptidase) (LAP) (Leucyl aminopeptidase); Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (503 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (314 aa) |
| | radC | DNA repair protein RadC homolog; Function of strongly homologous gene; cell process; Belongs to the UPF0758 family. (224 aa) |
| | sodB | Superoxide dismutase [Fe]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (192 aa) |
| | HEAR2512 | Putative cytochrome c; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (277 aa) |
| | HEAR2558 | Putative cytochrome c; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (464 aa) |
| | lapB | Conserved hypothetical protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. (391 aa) |
| | gph | Phosphoglycolate phosphatase (PGPase) (PGP); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (221 aa) |
| | HEAR2594 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (263 aa) |
| | guaC | GMP reductase (Guanosine 5'-monophosphate oxidoreductase) (Guanosine monophosphate reductase); Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (350 aa) |
| | cbbA | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase (Ketopantoate hydroxymethyltransferase) (KPHMT); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (276 aa) |
| | dnaJ | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (374 aa) |
| | hemH | Ferrochelatase (Protoheme ferro-lyase) (Heme synthetase); Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (368 aa) |
| | fur | Ferric uptake regulation protein (Ferric uptake regulator); Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the Fur family. (140 aa) |
| | cyoB | Cytochrome o ubiquinol oxidase subunit I; Function of homologous gene experimentally demonstrated in an other organism; carrier; Belongs to the heme-copper respiratory oxidase family. (667 aa) |
| | HEAR2721 | Phosphomannomutase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (458 aa) |
| | rubA2 | Rubredoxin (Rd); Function of homologous gene experimentally demonstrated in an other organism; carrier. (64 aa) |
| | nrdB | Ribonucleoside-diphosphate reductase subunit beta (Ribonucleotide reductase small subunit); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (395 aa) |
| | obg | Conserved hypothetical protein, putative GTPase; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (369 aa) |
| | yacG | Conserved hypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. (66 aa) |
| | secA | Preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (921 aa) |
| | lpxC | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (UDP-3-O-acyl-GlcNAc deacetylase); Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (311 aa) |
| | ddlB | D-alanine--D-alanine ligase B (D-alanylalanine synthetase B) (D-Ala-D-Ala ligase B); Cell wall formation. (334 aa) |
| | HEAR2825 | Putative cytochrome c4; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (238 aa) |
| | HEAR2826 | Cytochrome c, class I precursor; Function of strongly homologous gene; carrier. (429 aa) |
| | hprK | HPr kinase/phosphorylase (HPrK/P) (HPr(Ser) kinase/phosphorylase) HprK; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). (313 aa) |
| | mutM | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (273 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | ctaD | Cytochrome c oxidase subunit 1 (Cytochrome c oxidase polypeptide I) (Cytochrome aa3 subunit 1); Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (533 aa) |
| | ctaC | Cytochrome c oxidase, subunit II (Cytochrome aa3 subunit 2); Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). (386 aa) |
| | queC | Queuosine biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (233 aa) |
| | cca | 2',3'-cyclic phosphodiesterase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. (414 aa) |
| | HEAR2947 | Putative 5-formyltetrahydrofolate cyclo-ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (186 aa) |
| | metK | S-adenosylmethionine synthetase (Methionine adenosyltransferase) (AdoMet synthetase) (MAT); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (387 aa) |
| | dksA | DnaK suppressor protein; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. (151 aa) |
| | hslV | ATP-dependent protease HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (178 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (335 aa) |
| | HEAR3019 | Putative glutaredoxin-related protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier; Belongs to the glutaredoxin family. Monothiol subfamily. (104 aa) |
| | petC | Cytochrome c1 precursor; Function of strongly homologous gene; carrier. (254 aa) |
| | petB | Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (467 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase (PRA-CH); Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (134 aa) |
| | hisD | Histidinol dehydrogenase (HDH); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (438 aa) |
| | uvrA2 | UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (954 aa) |
| | kdsD | Arabinose 5-phosphate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the SIS family. GutQ/KpsF subfamily. (342 aa) |
| | HEAR3105 | Putative 3-Deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P phosphatase) kdsC-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (179 aa) |
| | aroBK | Bifunctional protein [Includes: 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (554 aa) |
| | cyaY | Frataxin-like; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (112 aa) |
| | msrQ | Conserved hypothetical protein; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, [...] (218 aa) |
| | msrP | Conserved hypothetical protein; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R [...] (326 aa) |
| | HEAR3134 | Cytochrome c4; Function of strongly homologous gene; carrier. (221 aa) |
| | engB | Putative GTP-binding protein; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (239 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase (Porphobilinogen synthase) (ALAD) (ALADH); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ALAD family. (337 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1414 aa) |
| | ttcA | Putative ATPase; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (318 aa) |
| | glmU | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (452 aa) |
| | HEAR3246 | Putative cytochrome c; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (125 aa) |
| | HEAR3247 | Putative cytochrome c, class I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; carrier. (231 aa) |
| | amaB | N-carbamoyl-L-amino acid hydrolase (L-carbamoylase); Function of strongly homologous gene; enzyme. (432 aa) |
| | copA3 | Copper-transporting P-type ATPase CopA (Protein CopA); Function of homologous gene experimentally demonstrated in an other organism; transporter. (815 aa) |
| | HEAR3299 | Putative Heavy metal transport/detoxification protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; cell process. (68 aa) |
| | HEAR3329 | Putative fumarate reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (118 aa) |
| | HEAR3342 | Putative molybdopterin oxidoreductase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (962 aa) |
| | HEAR3348 | Putative cytochrome c; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (181 aa) |
| | queH | Conserved hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (228 aa) |
| | dinB | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (386 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (682 aa) |
| | HEAR3397 | Putative Thiamine biosynthesis lipoprotein ApbE-like precursor; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein. Belongs to the ApbE family. (344 aa) |
| | piuC | PKHD-type hydroxylase PiuC (Iron-uptake factor PiuC); Function of strongly homologous gene; enzyme. (225 aa) |
| | fdsA | NAD-dependent formate dehydrogenase alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (956 aa) |
| | fdsB | NAD-dependent formate dehydrogenase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (525 aa) |
| | fdsG | NAD-dependent formate dehydrogenase gamma subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (159 aa) |
| | modA2 | Molybdate-binding periplasmic protein precursor; Function of homologous gene experimentally demonstrated in an other organism; transporter. (251 aa) |
| | HEAR3445 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (442 aa) |
| | icd2 | Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the monomeric-type IDH family. (742 aa) |
| | trmE | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (466 aa) |
