STRINGSTRING
HEAR0251 HEAR0251 ttuD ttuD HEAR0357 HEAR0357 fdhA1 fdhA1 fbp1 fbp1 acsA acsA ppc ppc frmC frmC HEAR1070 HEAR1070 pps pps HEAR1412 HEAR1412 fdhB fdhB HEAR1415 HEAR1415 ackA ackA mdh mdh serB serB frmB frmB HEAR2039 HEAR2039 fdhA2 fdhA2 eno eno glyA glyA HEAR2456 HEAR2456 serC serC cbbA cbbA sgaA sgaA gpmA1 gpmA1 gpmA2 gpmA2 fdsD fdsD fdsA fdsA fdsB fdsB fdsG fdsG fdh fdh HEAR3458 HEAR3458
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
HEAR0251Putative Phosphoglycerate/bisphosphoglycerate mutase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the phosphoglycerate mutase family. (216 aa)
ttuDPutative hydroxypyruvate reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (396 aa)
HEAR0357NADH dehydrogenase (Quinone); Function of strongly homologous gene; enzyme. (567 aa)
fdhA1Formate dehydrogenase, alpha subunit; Function of strongly homologous gene; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (946 aa)
fbp1Fructose-1,6-bisphosphatase (D-fructose-1, 6-bisphosphate 1-phosphohydrolase) (FBPase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (334 aa)
acsAAcetyl-coenzyme A synthetase (Acetate--CoA ligase) (Acyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
ppcPhosphoenolpyruvate carboxylase (PEPCase) (PEPC); Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (944 aa)
frmCS-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (280 aa)
HEAR1070S-(hydroxymethyl)glutathione dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (368 aa)
ppsPhosphoenolpyruvate synthase (Pyruvate, water dikinase) (PEP synthase); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (812 aa)
HEAR1412Putative formate dehydrogenase subunit A; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (988 aa)
fdhBFormate dehydrogenase iron-sulfur subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (209 aa)
HEAR1415Putative formate dehydrogenase subunit C; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (380 aa)
ackAAcetate kinase (Acetokinase); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (396 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
serBPhosphoserine phosphatase (PSP) (O-phosphoserine phosphohydrolase) (PSPase); Function of strongly homologous gene; enzyme. (281 aa)
frmBS-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (276 aa)
HEAR2039S-(hydroxymethyl)glutathione dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa)
fdhA2Glutathione-independent formaldehyde dehydrogenase (FDH) (FALDH); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (404 aa)
enoEnolase (2-phosphoglycerate dehydratase) (2-phospho-D-glycerate hydro-lyase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
glyASerine hydroxymethyltransferase (Serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (414 aa)
HEAR2456Putative flavin-containing monooxygenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (458 aa)
serCPhosphoserine aminotransferase (Phosphohydroxythreonine aminotransferase) (PSAT); Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (363 aa)
cbbAFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
sgaASerine--glyoxylate aminotransferase (SGAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (405 aa)
gpmA12,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (248 aa)
gpmA22,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (239 aa)
fdsDNAD-dependent formate dehydrogenase delta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (77 aa)
fdsANAD-dependent formate dehydrogenase alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (956 aa)
fdsBNAD-dependent formate dehydrogenase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (525 aa)
fdsGNAD-dependent formate dehydrogenase gamma subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (159 aa)
fdhFormate dehydrogenase (NAD-dependent formate dehydrogenase) (FDH); Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (400 aa)
HEAR3458Putative Phosphoglycerate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (327 aa)
Your Current Organism:
Herminiimonas arsenicoxydans
NCBI taxonomy Id: 204773
Other names: CCM 7303, DSM 17148, H. arsenicoxydans, Herminiimonas arsenicoxydans Muller et al. 2006, LMG 22961, LMG:22961, strain ULPAs1
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