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| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2295 aa) |
| | ddx23 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23. (806 aa) |
| | prim1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa) |
| | dscc1 | DNA replication and sister chromatid cohesion 1. (390 aa) |
| | ENSMAMP00000035212 | ATPase family AAA domain containing 5a. (1802 aa) |
| | ENSMAMP00000034838 | SET domain and mariner transposase fusion gene. (302 aa) |
| | helb | Helicase (DNA) B. (1066 aa) |
| | ENSMAMP00000034782 | TRAF-interacting protein. (426 aa) |
| | recql | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (644 aa) |
| | ticrr | Treslin_N domain-containing protein. (1879 aa) |
| | pola1 | DNA polymerase. (1480 aa) |
| | rfwd3 | Ring finger and WD repeat domain 3. (722 aa) |
| | gins1 | GINS complex subunit 1 (Psf1 homolog). (209 aa) |
| | orc4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa) |
| | nfic | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (524 aa) |
| | ENSMAMP00000032929 | Uncharacterized protein. (558 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (411 aa) |
| | ENSMAMP00000031984 | Centromere protein X. (63 aa) |
| | LOC113143510 | Uncharacterized protein. (661 aa) |
| | ENSMAMP00000031241 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (737 aa) |
| | gins2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa) |
| | ENSMAMP00000030060 | Essential meiotic structure-specific endonuclease 1. (511 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1400 aa) |
| | ENSMAMP00000029947 | Replication factor C subunit 1. (1137 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (672 aa) |
| | tatdn1 | TatD DNase domain containing 1. (316 aa) |
| | rnaseh1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (305 aa) |
| | ddx21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21. (744 aa) |
| | mgme1 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair. Belongs to the MGME1 family. (338 aa) |
| | grwd1 | Glutamate-rich WD repeat containing 1. (450 aa) |
| | ENSMAMP00000028854 | Uncharacterized protein. (188 aa) |
| | mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa) |
| | LOC113136783 | Cyclin E2; Belongs to the cyclin family. (395 aa) |
| | chaf1a | Chromatin assembly factor 1, subunit A (p150). (888 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa) |
| | kin | Kin17 DNA and RNA binding protein. (392 aa) |
| | ENSMAMP00000026490 | SDE2 telomere maintenance homolog (S. pombe). (487 aa) |
| | ENSMAMP00000026470 | Primase and polymerase (DNA-directed). (529 aa) |
| | pole3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (153 aa) |
| | LOC113132594 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (565 aa) |
| | rpain | RPA interacting protein. (227 aa) |
| | ssbp1 | Single-stranded DNA binding protein 1. (147 aa) |
| | ENSMAMP00000025964 | DNA helicase; Belongs to the MCM family. (825 aa) |
| | orc2 | Origin recognition complex, subunit 2. (574 aa) |
| | ENSMAMP00000025642 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (305 aa) |
| | wdr18 | WD repeat domain 18. (430 aa) |
| | ENSMAMP00000024975 | THO complex 1. (620 aa) |
| | wdhd1 | WD repeat and HMG-box DNA binding protein 1. (1123 aa) |
| | nfia | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (516 aa) |
| | ENSMAMP00000023695 | Inhibitor of growth protein. (231 aa) |
| | nfix | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (572 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (878 aa) |
| | ENSMAMP00000023139 | Polymerase (DNA directed) nu. (724 aa) |
| | recql4 | RecQ helicase-like 4. (1548 aa) |
| | prim2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (540 aa) |
| | orc1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (898 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | ZNF830 | Zinc finger protein 830. (349 aa) |
| | pclaf | PCNA clamp associated factor. (116 aa) |
| | ENSMAMP00000021732 | Replication factor C (activator 1) 3. (423 aa) |
| | ENSMAMP00000021691 | WRN helicase interacting protein 1. (621 aa) |
| | cdc45 | CDC45 cell division cycle 45 homolog (S. cerevisiae). (570 aa) |
| | rtel1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1175 aa) |
| | chaf1b | Chromatin assembly factor 1, subunit B. (606 aa) |
| | polb | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (336 aa) |
| | rrm2b | Ribonucleotide reductase M2 b. (364 aa) |
| | LOC113142856 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (793 aa) |
| | slx4 | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1831 aa) |
| | gins3 | GINS complex subunit 3. (211 aa) |
| | gmnn | Geminin DNA replication inhibitor. (226 aa) |
| | LOC113132371 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (584 aa) |
| | orc5 | Origin recognition complex, subunit 5. (444 aa) |
| | ENSMAMP00000020041 | Minichromosome maintenance complex binding protein. (633 aa) |
| | mcm2 | DNA helicase; Belongs to the MCM family. (890 aa) |
| | RFC2 | Replication factor C (activator 1) 2. (359 aa) |
| | ENSMAMP00000019064 | ATPase_AAA_core domain-containing protein. (146 aa) |
| | ENSMAMP00000019030 | ATPase_AAA_core domain-containing protein. (97 aa) |
| | ENSMAMP00000018993 | ATPase_AAA_core domain-containing protein. (157 aa) |
| | polk | Polymerase (DNA directed) kappa. (885 aa) |
| | ENSMAMP00000018103 | Uncharacterized protein. (1670 aa) |
| | chtf8 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (135 aa) |
| | supt16h | SPT16 homolog, facilitates chromatin remodeling subunit. (1029 aa) |
| | ENSMAMP00000017045 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (843 aa) |
| | LOC113122128 | Retinoblastoma binding protein 4, like. (427 aa) |
| | sirt7 | Sirtuin 7. (406 aa) |
| | rbm48 | RNA binding motif protein 48. (362 aa) |
| | LOC113140087 | Nuclear autoantigenic sperm protein (histone-binding). (426 aa) |
| | noc3l | Nucleolar complex protein 3 homolog. (805 aa) |
| | pold3 | Polymerase (DNA-directed), delta 3, accessory subunit. (441 aa) |
| | ENSMAMP00000015820 | DNA topoisomerase II binding protein 1. (1389 aa) |
| | ddx11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11. (888 aa) |
| | brca2 | BRCA2 DNA repair associated. (2876 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (698 aa) |
| | LOC113146214 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (765 aa) |
| | ENSMAMP00000015251 | HD domain-containing protein. (532 aa) |
| | ENSMAMP00000015211 | HD domain-containing protein. (179 aa) |
| | ENSMAMP00000015186 | HD domain-containing protein. (173 aa) |
| | ENSMAMP00000015156 | HD domain-containing protein. (560 aa) |
| | samhd1 | SAM domain and HD domain 1. (651 aa) |
| | poll | Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (568 aa) |
| | atrx | ATRX chromatin remodeler. (2018 aa) |
| | ENSMAMP00000013291 | DNA ligase. (987 aa) |
| | LOC113139345 | Uncharacterized protein. (655 aa) |
| | gins4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (230 aa) |
| | cdt1 | Chromatin licensing and DNA replication factor 1. (661 aa) |
| | ENSMAMP00000012848 | BLM RecQ like helicase. (1366 aa) |
| | LOC113132084 | Retinoblastoma binding protein 4. (424 aa) |
| | lig4 | DNA ligase. (915 aa) |
| | mcm5 | DNA helicase; Belongs to the MCM family. (737 aa) |
| | orc3 | Origin recognition complex, subunit 3. (722 aa) |
| | tonsl | Tonsoku-like, DNA repair protein. (1436 aa) |
| | gen1 | Uncharacterized protein. (908 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (470 aa) |
| | ENSMAMP00000010511 | Uncharacterized protein. (2126 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (381 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (376 aa) |
| | mcm3 | DNA helicase; Belongs to the MCM family. (814 aa) |
| | BAZ1A | Bromodomain adjacent to zinc finger domain 1A. (1474 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa) |
| | NFIB | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (562 aa) |
| | RBBP4 | RB binding protein 4, chromatin remodeling factor. (426 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (624 aa) |
| | cinp | Cyclin-dependent kinase 2 interacting protein. (206 aa) |
| | polg | Polymerase (DNA directed), gamma. (1203 aa) |
| | dtl | Denticleless E3 ubiquitin protein ligase homolog (Drosophila). (657 aa) |
| | ENSMAMP00000007108 | Timeless circadian clock. (1221 aa) |
| | twnk | Twinkle mtDNA helicase. (730 aa) |
| | zranb3 | Zinc finger, RAN-binding domain containing 3. (1149 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (335 aa) |
| | ENSMAMP00000006136 | Zgc:110269. (348 aa) |
| | donson | Uncharacterized protein. (627 aa) |
| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (126 aa) |
| | LOC113129257 | SCY domain-containing protein. (124 aa) |
| | RRM2-2 | Ribonucleoside-diphosphate reductase subunit M2. (385 aa) |
| | RRM2 | Ribonucleotide reductase regulatory subunit M2. (385 aa) |
| | pold4 | Si:dkey-28b4.7. (108 aa) |
| | ENSMAMP00000004522 | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (355 aa) |
| | mms22l | MMS22-like, DNA repair protein. (1232 aa) |
| | recql5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (999 aa) |
| | ENSMAMP00000004078 | Leucine-rich repeats and WD repeat domain containing 1. (712 aa) |
| | LOC113127778 | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (556 aa) |
| | rmi2 | RecQ mediated genome instability 2. (138 aa) |
| | ENSMAMP00000003022 | Uncharacterized protein. (510 aa) |
| | ENSMAMP00000003010 | ZPR1 zinc finger. (173 aa) |
| | ssrp1 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (705 aa) |
| | ing4 | Inhibitor of growth protein. (249 aa) |
| | ENSMAMP00000002715 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2574 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (698 aa) |
| | pold1 | DNA polymerase. (1119 aa) |
| | ttc38 | Tetratricopeptide repeat domain 38. (466 aa) |
| | NASP | Nuclear autoantigenic sperm protein. (500 aa) |
| | mcm10 | Minichromosome maintenance 10 replication initiation factor. (949 aa) |
| | lig3 | DNA ligase. (1011 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa) |
| | polq | Polymerase (DNA directed), theta. (2783 aa) |
| | LOC113128348 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (585 aa) |
| | smarcal1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (879 aa) |
| | rpa3 | Replication protein A3. (122 aa) |
| | pola2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa) |
| | fbh1 | F-box DNA helicase 1. (1089 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (644 aa) |
