(78 nodes) Embryonic skeletal system development network (Mastacembelus armatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113129872	Extracellular sulfatase. (885 aa)
	RING1	Ring finger protein 1. (381 aa)
	ENSMAMP00000034001	DEAF1 transcription factor. (557 aa)
	alx1	ALX homeobox 1. (315 aa)
	LOC113121622	Sharpin and rbck1 related. (703 aa)
	sulf1	Extracellular sulfatase. (867 aa)
	ilvbl	IlvB (bacterial acetolactate synthase)-like; Belongs to the TPP enzyme family. (625 aa)
	LOC113137382	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (388 aa)
	ucma	Upper zone of growth plate and cartilage matrix associated a. (133 aa)
	LOC113141118	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (386 aa)
	LOC113122492	Growth differentiation factor 6a. (448 aa)
	ENSMAMP00000002961	Growth arrest-specific 1b. (259 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (551 aa)
	ENSMAMP00000003718	Nipped-B protein. (2305 aa)
	alcam	Activated leukocyte cell adhesion molecule. (560 aa)
	dmrt2	Doublesex and mab-3 related transcription factor 2a. (542 aa)
	rad21	RAD21 cohesin complex component b. (625 aa)
	hand2	Heart and neural crest derivatives expressed 2. (245 aa)
	ENSMAMP00000005459	Sp3b transcription factor. (641 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (416 aa)
	ENSMAMP00000006759	WD repeat domain 60. (754 aa)
	sec23a	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa)
	LOC113122291	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (589 aa)
	ENSMAMP00000007850	Uncharacterized protein. (245 aa)
	dlx1	Distal-less homeobox 1a. (253 aa)
	dlx2	Distal-less homeobox 2b. (277 aa)
	SP3	Sp3a transcription factor. (699 aa)
	disp1	Dispatched homolog 1 (Drosophila). (1592 aa)
	pdgfrb	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1098 aa)
	LOC113145356	Homeobox C10a. (381 aa)
	hoxc9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (262 aa)
	dlx3	Distal-less homeobox 3b. (278 aa)
	LOC113130934	MyoD family inhibitor. (301 aa)
	egr1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (511 aa)
	ENSMAMP00000012901	Distal-less homeobox 5a. (306 aa)
	sema3d	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; Belongs to the semaphorin family. (805 aa)
	ENSMAMP00000013439	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
	LOC113145912	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	LOC113125290	Cytochrome P450, family 26, subfamily b, polypeptide 1; Belongs to the cytochrome P450 family. (512 aa)
	LOC113141978	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (407 aa)
	gdf5	Growth differentiation factor 5. (602 aa)
	ENSMAMP00000015080	Intraflagellar transport 140 homolog (Chlamydomonas). (1420 aa)
	LOC113130300	Si:dkey-49n23.1; Belongs to the semaphorin family. (821 aa)
	ALX3	ALX homeobox 3. (358 aa)
	mab21l1	Mab-21-like 1. (359 aa)
	ENSMAMP00000016446	Uncharacterized protein. (552 aa)
	leo1	LEO1 homolog, Paf1/RNA polymerase II complex component. (635 aa)
	rnf2	Ring finger protein 2. (430 aa)
	LOC113145670	Zgc:113363. (253 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2549 aa)
	bmp2	Bone morphogenetic protein 2b. (424 aa)
	fst	Follistatin a. (348 aa)
	s1pr2	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	ENSMAMP00000018306	Nipped-B protein. (2307 aa)
	gnptab	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta. (1254 aa)
	LOC113122718	RNA binding motif protein 24b. (235 aa)
	LOC113126503	RNA binding motif protein 24a. (232 aa)
	LOC113145267	Uncharacterized protein. (886 aa)
	mab21l2	Mab-21-like 2. (359 aa)
	ednra	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	ENSMAMP00000022063	RNA polymerase I and III subunit D. (107 aa)
	nbas	Neuroblastoma amplified sequence. (2374 aa)
	wnt9a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	LOC113125696	Activated leukocyte cell adhesion molecule b. (569 aa)
	fam20b	FAM20B glycosaminoglycan xylosylkinase. (409 aa)
	mmachc	Metabolism of cobalamin associated C. (266 aa)
	pitx2	Homeobox protein. (313 aa)
	ENSMAMP00000026570	GATA binding protein 3. (463 aa)
	ENSMAMP00000029060	Mediator complex subunit 12. (2101 aa)
	mks1	MKS transition zone complex subunit 1. (561 aa)
	ENSMAMP00000029987	WD repeat domain 19. (1330 aa)
	tbx1	T-box transcription factor 1. (501 aa)
	ENSMAMP00000030872	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
	ENSMAMP00000034550	Upper zone of growth plate and cartilage matrix associated b. (127 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	ENSMAMP00000035806	RAD21 cohesin complex component a. (619 aa)
	ENSMAMP00000036150	Rad21_Rec8 domain-containing protein. (60 aa)
	ENSMAMP00000036151	Rad21_Rec8_N domain-containing protein. (143 aa)

Your Current Organism:

Mastacembelus armatus

NCBI taxonomy Id: 205130
Other names: M. armatus, Macrognathus armatus, zig-zag eel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALX3	ENSMAMP00000026570	ENSMAMP00000015797	ENSMAMP00000026570	ALX homeobox 3.	GATA binding protein 3.	0.545
ALX3	hand2	ENSMAMP00000015797	ENSMAMP00000005274	ALX homeobox 3.	Heart and neural crest derivatives expressed 2.	0.484
ALX3	tbx1	ENSMAMP00000015797	ENSMAMP00000030827	ALX homeobox 3.	T-box transcription factor 1.	0.443
ENSMAMP00000002961	shh	ENSMAMP00000002961	ENSMAMP00000005694	Growth arrest-specific 1b.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.899
ENSMAMP00000003718	ENSMAMP00000035806	ENSMAMP00000003718	ENSMAMP00000035806	Nipped-B protein.	RAD21 cohesin complex component a.	0.928
ENSMAMP00000003718	ENSMAMP00000036150	ENSMAMP00000003718	ENSMAMP00000036150	Nipped-B protein.	Rad21_Rec8 domain-containing protein.	0.928
ENSMAMP00000003718	ENSMAMP00000036151	ENSMAMP00000003718	ENSMAMP00000036151	Nipped-B protein.	Rad21_Rec8_N domain-containing protein.	0.928
ENSMAMP00000003718	SETD2	ENSMAMP00000003718	ENSMAMP00000017790	Nipped-B protein.	SET domain containing 2, histone lysine methyltransferase.	0.796
ENSMAMP00000003718	rad21	ENSMAMP00000003718	ENSMAMP00000004934	Nipped-B protein.	RAD21 cohesin complex component b.	0.928
ENSMAMP00000005459	ENSMAMP00000035806	ENSMAMP00000005459	ENSMAMP00000035806	Sp3b transcription factor.	RAD21 cohesin complex component a.	0.438
ENSMAMP00000005459	ENSMAMP00000036150	ENSMAMP00000005459	ENSMAMP00000036150	Sp3b transcription factor.	Rad21_Rec8 domain-containing protein.	0.438
ENSMAMP00000005459	ENSMAMP00000036151	ENSMAMP00000005459	ENSMAMP00000036151	Sp3b transcription factor.	Rad21_Rec8_N domain-containing protein.	0.438
ENSMAMP00000005459	rad21	ENSMAMP00000005459	ENSMAMP00000004934	Sp3b transcription factor.	RAD21 cohesin complex component b.	0.438
ENSMAMP00000006759	ENSMAMP00000015080	ENSMAMP00000006759	ENSMAMP00000015080	WD repeat domain 60.	Intraflagellar transport 140 homolog (Chlamydomonas).	0.702
ENSMAMP00000006759	ENSMAMP00000029987	ENSMAMP00000006759	ENSMAMP00000029987	WD repeat domain 60.	WD repeat domain 19.	0.792
ENSMAMP00000007850	shh	ENSMAMP00000007850	ENSMAMP00000005694	Uncharacterized protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.899
ENSMAMP00000012901	bmp2	ENSMAMP00000012901	ENSMAMP00000017952	Distal-less homeobox 5a.	Bone morphogenetic protein 2b.	0.549
ENSMAMP00000013439	ENSMAMP00000030872	ENSMAMP00000013439	ENSMAMP00000030872	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.841
ENSMAMP00000013439	fst	ENSMAMP00000013439	ENSMAMP00000017989	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Follistatin a.	0.404
ENSMAMP00000013439	hand2	ENSMAMP00000013439	ENSMAMP00000005274	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Heart and neural crest derivatives expressed 2.	0.470