(12 nodes) DHS-like NAD/FAD-binding domain superfamily network (Mastacembelus armatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSMAMP00000019592	Deacetylase sirtuin-type domain-containing protein. (694 aa)
	hacl1	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (568 aa)
	sirt5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (305 aa)
	LOC113134951	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (305 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (309 aa)
	LOC113132980	Si:dkey-103i16.6. (442 aa)
	LOC113124488	Nicotinamide nucleotide transhydrogenase. (1135 aa)
	sirt7	Sirtuin 7. (406 aa)
	LOC113138015	Nicotinamide nucleotide transhydrogenase 2. (1071 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (383 aa)
	ilvbl	IlvB (bacterial acetolactate synthase)-like; Belongs to the TPP enzyme family. (625 aa)
	etfa	Electron transfer flavoprotein subunit alpha. (333 aa)

Your Current Organism:

Mastacembelus armatus

NCBI taxonomy Id: 205130
Other names: M. armatus, Macrognathus armatus, zig-zag eel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMAMP00000019592	LOC113124488	ENSMAMP00000019592	ENSMAMP00000014107	Deacetylase sirtuin-type domain-containing protein.	Nicotinamide nucleotide transhydrogenase.	0.843
ENSMAMP00000019592	LOC113132980	ENSMAMP00000019592	ENSMAMP00000009510	Deacetylase sirtuin-type domain-containing protein.	Si:dkey-103i16.6.	0.915
ENSMAMP00000019592	LOC113134951	ENSMAMP00000019592	ENSMAMP00000021220	Deacetylase sirtuin-type domain-containing protein.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.867
ENSMAMP00000019592	LOC113138015	ENSMAMP00000019592	ENSMAMP00000017419	Deacetylase sirtuin-type domain-containing protein.	Nicotinamide nucleotide transhydrogenase 2.	0.843
ENSMAMP00000019592	sirt2	ENSMAMP00000019592	ENSMAMP00000018711	Deacetylase sirtuin-type domain-containing protein.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.930
ENSMAMP00000019592	sirt4	ENSMAMP00000019592	ENSMAMP00000035261	Deacetylase sirtuin-type domain-containing protein.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.909
ENSMAMP00000019592	sirt5	ENSMAMP00000019592	ENSMAMP00000021103	Deacetylase sirtuin-type domain-containing protein.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.866
ENSMAMP00000019592	sirt7	ENSMAMP00000019592	ENSMAMP00000016918	Deacetylase sirtuin-type domain-containing protein.	Sirtuin 7.	0.950
LOC113124488	ENSMAMP00000019592	ENSMAMP00000014107	ENSMAMP00000019592	Nicotinamide nucleotide transhydrogenase.	Deacetylase sirtuin-type domain-containing protein.	0.843
LOC113124488	LOC113132980	ENSMAMP00000014107	ENSMAMP00000009510	Nicotinamide nucleotide transhydrogenase.	Si:dkey-103i16.6.	0.842
LOC113124488	LOC113134951	ENSMAMP00000014107	ENSMAMP00000021220	Nicotinamide nucleotide transhydrogenase.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.842
LOC113124488	LOC113138015	ENSMAMP00000014107	ENSMAMP00000017419	Nicotinamide nucleotide transhydrogenase.	Nicotinamide nucleotide transhydrogenase 2.	0.842
LOC113124488	sirt2	ENSMAMP00000014107	ENSMAMP00000018711	Nicotinamide nucleotide transhydrogenase.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.842
LOC113124488	sirt4	ENSMAMP00000014107	ENSMAMP00000035261	Nicotinamide nucleotide transhydrogenase.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.842
LOC113124488	sirt5	ENSMAMP00000014107	ENSMAMP00000021103	Nicotinamide nucleotide transhydrogenase.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.842
LOC113124488	sirt7	ENSMAMP00000014107	ENSMAMP00000016918	Nicotinamide nucleotide transhydrogenase.	Sirtuin 7.	0.845
LOC113132980	ENSMAMP00000019592	ENSMAMP00000009510	ENSMAMP00000019592	Si:dkey-103i16.6.	Deacetylase sirtuin-type domain-containing protein.	0.915
LOC113132980	LOC113124488	ENSMAMP00000009510	ENSMAMP00000014107	Si:dkey-103i16.6.	Nicotinamide nucleotide transhydrogenase.	0.842
LOC113132980	LOC113134951	ENSMAMP00000009510	ENSMAMP00000021220	Si:dkey-103i16.6.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.875
LOC113132980	LOC113138015	ENSMAMP00000009510	ENSMAMP00000017419	Si:dkey-103i16.6.	Nicotinamide nucleotide transhydrogenase 2.	0.842