STRINGSTRING
rpa1 rpa1 chek1 chek1 mcm7 mcm7 RPA1 RPA1 hus1 hus1 LOC113127185 LOC113127185 ENSMAMP00000033281 ENSMAMP00000033281 orc4 orc4 orc1 orc1 mcm4 mcm4 RCBTB1 RCBTB1 orc2 orc2 ENSMAMP00000025964 ENSMAMP00000025964 CDC25B CDC25B rpa3 rpa3 LOC113128348 LOC113128348 mcm10 mcm10 atrip atrip rad9a rad9a ENSMAMP00000002715 ENSMAMP00000002715 CLSPN CLSPN rad17 rad17 rfc5 rfc5 ENSMAMP00000007077 ENSMAMP00000007077 ENSMAMP00000007755 ENSMAMP00000007755 cdk2 cdk2 mcm3 mcm3 rfc4 rfc4 rpa2 rpa2 orc3 orc3 mcm5 mcm5 rcbtb2 rcbtb2 ENSMAMP00000018993 ENSMAMP00000018993 ENSMAMP00000019030 ENSMAMP00000019030 ENSMAMP00000019064 ENSMAMP00000019064 RFC2 RFC2 dbf4 dbf4 mcm2 mcm2 orc5 orc5 LOC113132371 LOC113132371 cdc45 cdc45 ENSMAMP00000021732 ENSMAMP00000021732 ENSMAMP00000022264 ENSMAMP00000022264
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (490 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (672 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (315 aa)
LOC113127185Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (529 aa)
ENSMAMP00000033281Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (785 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (898 aa)
mcm4DNA helicase; Belongs to the MCM family. (878 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
orc2Origin recognition complex, subunit 2. (574 aa)
ENSMAMP00000025964DNA helicase; Belongs to the MCM family. (825 aa)
CDC25BCell division cycle 25B. (575 aa)
rpa3Replication protein A3. (122 aa)
LOC113128348Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (585 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (949 aa)
atripUncharacterized protein. (812 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (387 aa)
ENSMAMP00000002715ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2574 aa)
CLSPNClaspin. (1288 aa)
rad17RAD17 checkpoint clamp loader component. (636 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
ENSMAMP00000007077Cell division cycle 7 homolog (S. cerevisiae). (580 aa)
ENSMAMP00000007755Protein kinase domain-containing protein. (164 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
mcm3DNA helicase; Belongs to the MCM family. (814 aa)
rfc4Replication factor C (activator 1) 4. (376 aa)
rpa2Replication protein A2. (272 aa)
orc3Origin recognition complex, subunit 3. (722 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
ENSMAMP00000018993ATPase_AAA_core domain-containing protein. (157 aa)
ENSMAMP00000019030ATPase_AAA_core domain-containing protein. (97 aa)
ENSMAMP00000019064ATPase_AAA_core domain-containing protein. (146 aa)
RFC2Replication factor C (activator 1) 2. (359 aa)
dbf4DBF4 zinc finger. (628 aa)
mcm2DNA helicase; Belongs to the MCM family. (890 aa)
orc5Origin recognition complex, subunit 5. (444 aa)
LOC113132371Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (584 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (570 aa)
ENSMAMP00000021732Replication factor C (activator 1) 3. (423 aa)
ENSMAMP00000022264RAD1 homolog (S. pombe). (332 aa)
Your Current Organism:
Mastacembelus armatus
NCBI taxonomy Id: 205130
Other names: M. armatus, Macrognathus armatus, zig-zag eel
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