STRINGSTRING
pcna pcna apex2 apex2 ENSMAMP00000035212 ENSMAMP00000035212 apex1 apex1 fen1 fen1 LOC113127185 LOC113127185 ENSMAMP00000029947 ENSMAMP00000029947 RPA1 RPA1 rpa1 rpa1 pole3 pole3 RCBTB1 RCBTB1 pole pole ENSMAMP00000021732 ENSMAMP00000021732 polb polb RFC2 RFC2 ENSMAMP00000019064 ENSMAMP00000019064 ENSMAMP00000019030 ENSMAMP00000019030 ENSMAMP00000018993 ENSMAMP00000018993 rcbtb2 rcbtb2 pold3 pold3 ENSMAMP00000013291 ENSMAMP00000013291 pold2 pold2 rpa2 rpa2 rfc4 rfc4 pole2 pole2 meiob meiob rfc5 rfc5 ENSMAMP00000006136 ENSMAMP00000006136 pole4 pole4 pold4 pold4 ENSMAMP00000003022 ENSMAMP00000003022 pold1 pold1 rpa3 rpa3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
apex2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (581 aa)
ENSMAMP00000035212ATPase family AAA domain containing 5a. (1802 aa)
apex1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (343 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (411 aa)
LOC113127185Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (529 aa)
ENSMAMP00000029947Replication factor C subunit 1. (1137 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (672 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (153 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2295 aa)
ENSMAMP00000021732Replication factor C (activator 1) 3. (423 aa)
polbDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (336 aa)
RFC2Replication factor C (activator 1) 2. (359 aa)
ENSMAMP00000019064ATPase_AAA_core domain-containing protein. (146 aa)
ENSMAMP00000019030ATPase_AAA_core domain-containing protein. (97 aa)
ENSMAMP00000018993ATPase_AAA_core domain-containing protein. (157 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (441 aa)
ENSMAMP00000013291DNA ligase. (987 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (470 aa)
rpa2Replication protein A2. (272 aa)
rfc4Replication factor C (activator 1) 4. (376 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
meiobMethionine sulfoxide reductase B1b. (469 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
ENSMAMP00000006136Zgc:110269. (348 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (126 aa)
pold4Si:dkey-28b4.7. (108 aa)
ENSMAMP00000003022Uncharacterized protein. (510 aa)
pold1DNA polymerase. (1119 aa)
rpa3Replication protein A3. (122 aa)
Your Current Organism:
Mastacembelus armatus
NCBI taxonomy Id: 205130
Other names: M. armatus, Macrognathus armatus, zig-zag eel
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