STRINGSTRING
ENSMAMP00000023615 ENSMAMP00000023615 brca1 brca1 ENSMAMP00000023704 ENSMAMP00000023704 kat5 kat5 RCBTB1 RCBTB1 ENSMAMP00000025642 ENSMAMP00000025642 pole3 pole3 rad17 rad17 rpa1 rpa1 ENSMAMP00000026820 ENSMAMP00000026820 ENSMAMP00000027426 ENSMAMP00000027426 chek1 chek1 rnf169 rnf169 rpa2 rpa2 babam1 babam1 rad52 rad52 rfc4 rfc4 ankrd12 ankrd12 top3a top3a uba52 uba52 LOC113134865 LOC113134865 pias4 pias4 RPA1 RPA1 ENSMAMP00000029925 ENSMAMP00000029925 ENSMAMP00000029931 ENSMAMP00000029931 ENSMAMP00000029947 ENSMAMP00000029947 DNA2 DNA2 ENSMAMP00000030060 ENSMAMP00000030060 ENSMAMP00000030253 ENSMAMP00000030253 pole2 pole2 meiob meiob ube2n ube2n cdca7 cdca7 LOC113140814 LOC113140814 cdk2 cdk2 ENSMAMP00000007755 ENSMAMP00000007755 ENSMAMP00000007108 ENSMAMP00000007108 rnf8 rnf8 rfc5 rfc5 LOC113129987 LOC113129987 tdrd3 tdrd3 mdc1 mdc1 ENSMAMP00000005495 ENSMAMP00000005495 pole4 pole4 pold4 pold4 ENSMAMP00000003996 ENSMAMP00000003996 rmi2 rmi2 LOC113125640 LOC113125640 ENSMAMP00000002715 ENSMAMP00000002715 LOC113142143 LOC113142143 ENSMAMP00000015820 ENSMAMP00000015820 ENSMAMP00000015732 ENSMAMP00000015732 brca2 brca2 mre11 mre11 cdca7l cdca7l mus81 mus81 polh polh rad50 rad50 hus1 hus1 LOC113127185 LOC113127185 ENSMAMP00000033310 ENSMAMP00000033310 ENSMAMP00000033312 ENSMAMP00000033312 rps27a rps27a ENSMAMP00000033998 ENSMAMP00000033998 ppp4r2 ppp4r2 sumo2 sumo2 pold3 pold3 ENSMAMP00000016271 ENSMAMP00000016271 sirt7 sirt7 slf1 slf1 ENSMAMP00000016919 ENSMAMP00000016919 rad51c rad51c LOC113132336 LOC113132336 rcbtb2 rcbtb2 ENSMAMP00000018168 ENSMAMP00000018168 polk polk ENSMAMP00000018386 ENSMAMP00000018386 LOC113124974 LOC113124974 ENSMAMP00000018993 ENSMAMP00000018993 ENSMAMP00000019030 ENSMAMP00000019030 LOC113145321 LOC113145321 ENSMAMP00000019064 ENSMAMP00000019064 RFC2 RFC2 nbn nbn ENSMAMP00000019646 ENSMAMP00000019646 rad51ap1 rad51ap1 slx4 slx4 ccna1 ccna1 babam2 babam2 ENSMAMP00000021732 ENSMAMP00000021732 rhno1 rhno1 ENSMAMP00000022246 ENSMAMP00000022246 pole pole ENSMAMP00000022264 ENSMAMP00000022264 pcna pcna ENSMAMP00000022465 ENSMAMP00000022465 SPIDR SPIDR rad9a rad9a rmi1 rmi1 ppp4c ppp4c LOC113123972 LOC113123972 ankrd11 ankrd11 atrip atrip pold1 pold1 LOC113142797 LOC113142797 LOC113128185 LOC113128185 ENSMAMP00000002197 ENSMAMP00000002197 ENSMAMP00000002154 ENSMAMP00000002154 ENSMAMP00000001831 ENSMAMP00000001831 ENSMAMP00000001732 ENSMAMP00000001732 ENSMAMP00000001719 ENSMAMP00000001719 ENSMAMP00000001553 ENSMAMP00000001553 rad51 rad51 LOC113128524 LOC113128524 rad51d rad51d rpa3 rpa3 exd2 exd2 ENSMAMP00000000117 ENSMAMP00000000117 ENSMAMP00000014297 ENSMAMP00000014297 ube2i ube2i sirt6 sirt6 ENSMAMP00000012848 ENSMAMP00000012848 ENSMAMP00000011414 ENSMAMP00000011414 ENSMAMP00000011048 ENSMAMP00000011048 gen1 gen1 pold2 pold2 kxd1 kxd1 palb2 palb2 recql4 recql4 ube2v2 ube2v2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMAMP00000023615Cyclin A2; Belongs to the cyclin family. (423 aa)
brca1Uncharacterized protein. (1442 aa)
ENSMAMP00000023704Histone H2B; Belongs to the histone H2B family. (132 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (562 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
ENSMAMP00000025642TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (305 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (153 aa)
rad17RAD17 checkpoint clamp loader component. (636 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
ENSMAMP00000026820SAE2 domain-containing protein. (90 aa)
ENSMAMP00000027426RECA_2 domain-containing protein. (291 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (490 aa)
rnf169Ring finger protein 169. (589 aa)
rpa2Replication protein A2. (272 aa)
babam1BRISC and BRCA1 A complex member 1. (373 aa)
rad52RAD52 homolog, DNA repair protein. (437 aa)
rfc4Replication factor C (activator 1) 4. (376 aa)
ankrd12Ankyrin repeat domain 12. (1938 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1034 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
LOC113134865Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
pias4Protein inhibitor of activated STAT, 4a. (497 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (672 aa)
ENSMAMP00000029925Histone H2B; Belongs to the histone H2B family. (113 aa)
ENSMAMP00000029931Histone H2B; Belongs to the histone H2B family. (129 aa)
ENSMAMP00000029947Replication factor C subunit 1. (1137 aa)
DNA2DNA replication helicase/nuclease 2. (1400 aa)
ENSMAMP00000030060Essential meiotic structure-specific endonuclease 1. (511 aa)
ENSMAMP00000030253Histone H2B; Belongs to the histone H2B family. (153 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
meiobMethionine sulfoxide reductase B1b. (469 aa)
ube2nUbiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
cdca7Cell division cycle associated 7a. (400 aa)
LOC113140814UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
ENSMAMP00000007755Protein kinase domain-containing protein. (164 aa)
ENSMAMP00000007108Timeless circadian clock. (1221 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (534 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
LOC113129987Ubiquitin-like domain-containing protein. (99 aa)
tdrd3Tudor domain containing 3. (785 aa)
mdc1Uncharacterized protein. (1884 aa)
ENSMAMP00000005495Non-specific serine/threonine protein kinase. (3067 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (126 aa)
pold4Si:dkey-28b4.7. (108 aa)
ENSMAMP00000003996Uncharacterized protein; Belongs to the histone H2B family. (157 aa)
rmi2RecQ mediated genome instability 2. (138 aa)
LOC113125640Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (261 aa)
ENSMAMP00000002715ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2574 aa)
LOC113142143UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
ENSMAMP00000015820DNA topoisomerase II binding protein 1. (1389 aa)
ENSMAMP00000015732Histone H2B; Belongs to the histone H2B family. (118 aa)
brca2BRCA2 DNA repair associated. (2876 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (698 aa)
cdca7lCell division cycle associated 7b. (409 aa)
mus81MUS81 structure-specific endonuclease subunit. (627 aa)
polhPolymerase (DNA directed), eta. (734 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (315 aa)
LOC113127185Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (529 aa)
ENSMAMP00000033310Uncharacterized protein. (533 aa)
ENSMAMP00000033312RAP80_UIM domain-containing protein. (151 aa)
rps27aRibosomal protein S27a. (156 aa)
ENSMAMP00000033998BRCA1/BRCA2-containing complex, subunit 3. (264 aa)
ppp4r2Protein phosphatase 4, regulatory subunit 2b. (422 aa)
sumo2Small ubiquitin-related modifier. (95 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (441 aa)
ENSMAMP00000016271Reverse transcriptase domain-containing protein. (293 aa)
sirt7Sirtuin 7. (406 aa)
slf1SMC5-SMC6 complex localization factor 1. (879 aa)
ENSMAMP00000016919Histone H2A; Belongs to the histone H2A family. (136 aa)
rad51cRAD51 paralog C. (363 aa)
LOC113132336Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
ENSMAMP00000018168annotation not available (93 aa)
polkPolymerase (DNA directed) kappa. (885 aa)
ENSMAMP00000018386Abraxas 1, BRCA1 A complex subunit. (336 aa)
LOC113124974Tyrosine-protein kinase. (1122 aa)
ENSMAMP00000018993ATPase_AAA_core domain-containing protein. (157 aa)
ENSMAMP00000019030ATPase_AAA_core domain-containing protein. (97 aa)
LOC113145321Uncharacterized protein. (411 aa)
ENSMAMP00000019064ATPase_AAA_core domain-containing protein. (146 aa)
RFC2Replication factor C (activator 1) 2. (359 aa)
nbnNibrin. (845 aa)
ENSMAMP00000019646Reverse transcriptase domain-containing protein. (271 aa)
rad51ap1RAD51 associated protein 1. (322 aa)
slx4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1831 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (402 aa)
babam2BRISC and BRCA1 A complex member 2. (386 aa)
ENSMAMP00000021732Replication factor C (activator 1) 3. (423 aa)
rhno1Si:ch73-352p4.5. (294 aa)
ENSMAMP00000022246Reverse transcriptase domain-containing protein. (271 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2295 aa)
ENSMAMP00000022264RAD1 homolog (S. pombe). (332 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
ENSMAMP00000022465Reverse transcriptase domain-containing protein. (357 aa)
SPIDRScaffold protein involved in DNA repair. (937 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (387 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (698 aa)
ppp4cSerine/threonine-protein phosphatase. (311 aa)
LOC113123972Small ubiquitin-related modifier. (95 aa)
ankrd11Ankyrin repeat domain 11. (2837 aa)
atripUncharacterized protein. (812 aa)
pold1DNA polymerase. (1119 aa)
LOC113142797Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC113128185Small ubiquitin-related modifier. (96 aa)
ENSMAMP00000002197Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (156 aa)
ENSMAMP00000002154DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (350 aa)
ENSMAMP00000001831Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa)
ENSMAMP00000001732Histone H2B; Belongs to the histone H2B family. (117 aa)
ENSMAMP00000001719UBIQUITIN_CONJUGAT_2 domain-containing protein. (148 aa)
ENSMAMP00000001553Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
LOC113128524Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
rad51dRAD51 paralog D. (333 aa)
rpa3Replication protein A3. (122 aa)
exd2Exonuclease 3'-5' domain containing 2. (644 aa)
ENSMAMP00000000117Nuclear receptor binding SET domain protein 2. (1285 aa)
ENSMAMP00000014297Reverse transcriptase domain-containing protein. (699 aa)
ube2iUbiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
sirt6Sirtuin 6. (348 aa)
ENSMAMP00000012848BLM RecQ like helicase. (1366 aa)
ENSMAMP00000011414Exonuclease 1. (740 aa)
ENSMAMP00000011048Uncharacterized protein. (139 aa)
gen1Uncharacterized protein. (908 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (470 aa)
kxd1KxDL motif containing 1. (184 aa)
palb2PALB2_WD40 domain-containing protein. (1404 aa)
recql4RecQ helicase-like 4. (1548 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
Your Current Organism:
Mastacembelus armatus
NCBI taxonomy Id: 205130
Other names: M. armatus, Macrognathus armatus, zig-zag eel
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