STRINGSTRING
ENSMAMP00000035212 ENSMAMP00000035212 parp3 parp3 ENSMAMP00000035870 ENSMAMP00000035870 apex2 apex2 NTHL1 NTHL1 ENSMAMP00000018114 ENSMAMP00000018114 ENSMAMP00000018168 ENSMAMP00000018168 ENSMAMP00000018993 ENSMAMP00000018993 ENSMAMP00000019030 ENSMAMP00000019030 ENSMAMP00000019064 ENSMAMP00000019064 RFC2 RFC2 ENSMAMP00000019120 ENSMAMP00000019120 pnkp pnkp rcbtb2 rcbtb2 LOC113132336 LOC113132336 ENSMAMP00000016919 ENSMAMP00000016919 ENSMAMP00000016385 ENSMAMP00000016385 ENSMAMP00000016350 ENSMAMP00000016350 ENSMAMP00000016318 ENSMAMP00000016318 pold3 pold3 ENSMAMP00000015732 ENSMAMP00000015732 xrcc1 xrcc1 ENSMAMP00000013291 ENSMAMP00000013291 parp2 parp2 LOC113124613 LOC113124613 pold2 pold2 rpa2 rpa2 ENSMAMP00000010610 ENSMAMP00000010610 rfc4 rfc4 pole2 pole2 meiob meiob rfc5 rfc5 ENSMAMP00000006223 ENSMAMP00000006223 ENSMAMP00000006136 ENSMAMP00000006136 smug1 smug1 LOC113138449 LOC113138449 pole4 pole4 mpg mpg pold4 pold4 ENSMAMP00000004556 ENSMAMP00000004556 ENSMAMP00000003996 ENSMAMP00000003996 ENSMAMP00000003224 ENSMAMP00000003224 ENSMAMP00000003022 ENSMAMP00000003022 ENSMAMP00000002489 ENSMAMP00000002489 LOC113125622 LOC113125622 pold1 pold1 LOC113142797 LOC113142797 LOC113142796 LOC113142796 ENSMAMP00000002197 ENSMAMP00000002197 ENSMAMP00000001831 ENSMAMP00000001831 ENSMAMP00000001732 ENSMAMP00000001732 ENSMAMP00000001553 ENSMAMP00000001553 lig3 lig3 MUTYH MUTYH LOC113128524 LOC113128524 rpa3 rpa3 ENSMAMP00000019589 ENSMAMP00000019589 ENSMAMP00000020176 ENSMAMP00000020176 polb polb ENSMAMP00000021732 ENSMAMP00000021732 pole pole pcna pcna LOC113121578 LOC113121578 ung ung ENSMAMP00000023704 ENSMAMP00000023704 ENSMAMP00000024197 ENSMAMP00000024197 RCBTB1 RCBTB1 neil3 neil3 pole3 pole3 rpa1 rpa1 ENSMAMP00000028361 ENSMAMP00000028361 LOC113135582 LOC113135582 ENSMAMP00000029072 ENSMAMP00000029072 RPA1 RPA1 ENSMAMP00000029925 ENSMAMP00000029925 ENSMAMP00000029931 ENSMAMP00000029931 ENSMAMP00000029947 ENSMAMP00000029947 LOC113146398 LOC113146398 ENSMAMP00000030243 ENSMAMP00000030243 ENSMAMP00000030253 ENSMAMP00000030253 parp1 parp1 LOC113131871 LOC113131871 LOC113127185 LOC113127185 fen1 fen1 ENSMAMP00000033957 ENSMAMP00000033957 LOC113133528 LOC113133528 LOC113132997 LOC113132997 apex1 apex1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMAMP00000035212ATPase family AAA domain containing 5a. (1802 aa)
parp3Poly [ADP-ribose] polymerase. (531 aa)
ENSMAMP00000035870Methyl-CpG binding domain protein 4. (175 aa)
apex2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (581 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (276 aa)
ENSMAMP00000018114Uncharacterized protein. (493 aa)
ENSMAMP00000018168annotation not available (93 aa)
ENSMAMP00000018993ATPase_AAA_core domain-containing protein. (157 aa)
ENSMAMP00000019030ATPase_AAA_core domain-containing protein. (97 aa)
ENSMAMP00000019064ATPase_AAA_core domain-containing protein. (146 aa)
RFC2Replication factor C (activator 1) 2. (359 aa)
ENSMAMP000000191208-oxoguanine DNA glycosylase. (385 aa)
pnkpPolynucleotide kinase 3'-phosphatase. (595 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
LOC113132336Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ENSMAMP00000016919Histone H2A; Belongs to the histone H2A family. (136 aa)
ENSMAMP00000016385Histone H2A; Belongs to the histone H2A family. (130 aa)
ENSMAMP00000016350Histone H2A; Belongs to the histone H2A family. (129 aa)
ENSMAMP00000016318Von Willebrand factor A domain containing 5B2. (1046 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (441 aa)
ENSMAMP00000015732Histone H2B; Belongs to the histone H2B family. (118 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (630 aa)
ENSMAMP00000013291DNA ligase. (987 aa)
parp2Poly [ADP-ribose] polymerase. (649 aa)
LOC113124613Poly (ADP-ribose) glycohydrolase, like. (710 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (470 aa)
rpa2Replication protein A2. (272 aa)
ENSMAMP00000010610Nei-like DNA glycosylase 1. (455 aa)
rfc4Replication factor C (activator 1) 4. (376 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
meiobMethionine sulfoxide reductase B1b. (469 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
ENSMAMP00000006223Si:cabz01080528.1. (716 aa)
ENSMAMP00000006136Zgc:110269. (348 aa)
smug1Single-strand-selective monofunctional uracil-DNA glycosylase 1. (282 aa)
LOC113138449Histone H2A; Belongs to the histone H2A family. (175 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (126 aa)
mpgN-methylpurine DNA glycosylase. (314 aa)
pold4Si:dkey-28b4.7. (108 aa)
ENSMAMP00000004556Si:ch1073-75f15.2. (92 aa)
ENSMAMP00000003996Uncharacterized protein; Belongs to the histone H2B family. (157 aa)
ENSMAMP00000003224Histone H2A; Belongs to the histone H2A family. (136 aa)
ENSMAMP00000003022Uncharacterized protein. (510 aa)
ENSMAMP00000002489Histone H2A; Belongs to the histone H2A family. (134 aa)
LOC113125622Histone H2A; Belongs to the histone H2A family. (128 aa)
pold1DNA polymerase. (1119 aa)
LOC113142797Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC113142796Histone H2A; Belongs to the histone H2A family. (128 aa)
ENSMAMP00000002197Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (156 aa)
ENSMAMP00000001831Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa)
ENSMAMP00000001732Histone H2B; Belongs to the histone H2B family. (117 aa)
ENSMAMP00000001553Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
lig3DNA ligase. (1011 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (527 aa)
LOC113128524Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
rpa3Replication protein A3. (122 aa)
ENSMAMP00000019589FHA_2 domain-containing protein. (51 aa)
ENSMAMP00000020176ADP-ribosylhydrolase like 2. (403 aa)
polbDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (336 aa)
ENSMAMP00000021732Replication factor C (activator 1) 3. (423 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2295 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
LOC113121578TINF2_N domain-containing protein. (585 aa)
ungUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (300 aa)
ENSMAMP00000023704Histone H2B; Belongs to the histone H2B family. (132 aa)
ENSMAMP00000024197Histone H2A; Belongs to the histone H2A family. (136 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
neil3Nei-like DNA glycosylase 3. (582 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (153 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
ENSMAMP00000028361Si:dkey-117m1.4. (753 aa)
LOC113135582Uncharacterized protein. (814 aa)
ENSMAMP00000029072Histone H2A; Belongs to the histone H2A family. (138 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (672 aa)
ENSMAMP00000029925Histone H2B; Belongs to the histone H2B family. (113 aa)
ENSMAMP00000029931Histone H2B; Belongs to the histone H2B family. (129 aa)
ENSMAMP00000029947Replication factor C subunit 1. (1137 aa)
LOC113146398HTH myb-type domain-containing protein. (608 aa)
ENSMAMP00000030243Histone H2A; Belongs to the histone H2A family. (134 aa)
ENSMAMP00000030253Histone H2B; Belongs to the histone H2B family. (153 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1010 aa)
LOC113131871Poly (ADP-ribose) glycohydrolase a. (774 aa)
LOC113127185Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (529 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (411 aa)
ENSMAMP00000033957Protection of telomeres 1 homolog. (805 aa)
LOC113133528Thymine DNA glycosylase, tandem duplicate 1. (453 aa)
LOC113132997Thymine DNA glycosylase, tandem duplicate 2. (398 aa)
apex1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (343 aa)
Your Current Organism:
Mastacembelus armatus
NCBI taxonomy Id: 205130
Other names: M. armatus, Macrognathus armatus, zig-zag eel
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.