(76 nodes) Ferroptosis network (Mastacembelus armatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	slc39a8	Solute carrier family 39 member 8. (464 aa)
	LOC113145840	Poly(rC) binding protein 2. (318 aa)
	LOC113130303	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (745 aa)
	LOC113127168	Cytochrome b-245, beta polypeptide (chronic granulomatous disease). (565 aa)
	ncoa4	Nuclear receptor coactivator 4. (593 aa)
	ENSMAMP00000033185	Uncharacterized protein. (324 aa)
	LOC113144280	Microtubule-associated protein 1 light chain 3 gamma, like. (135 aa)
	steap2	STEAP family member 2, metalloreductase. (516 aa)
	acsl6	AMP-binding domain-containing protein. (722 aa)
	LOC113131405	Voltage-dependent anion channel 2. (283 aa)
	xkrx	XK-related protein. (494 aa)
	nox1	NADPH oxidase 1. (566 aa)
	map1lc3c	Microtubule-associated protein 1 light chain 3 gamma. (128 aa)
	ENSMAMP00000027755	Uncharacterized protein. (181 aa)
	ENSMAMP00000027740	Transferrin receptor 1a. (769 aa)
	LOC113128109	Acyl-CoA synthetase long chain family member 1a. (755 aa)
	LOC113142989	Spermidine/spermine N1-acetyltransferase 1. (169 aa)
	VDAC2	Voltage dependent anion channel 2. (283 aa)
	LOC113140443	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (252 aa)
	LOC113140444	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (176 aa)
	ACSL1	Acyl-CoA synthetase long chain family member 1. (692 aa)
	ENSMAMP00000024093	AMP-binding domain-containing protein. (692 aa)
	slc39a14	Solute carrier family 39 member 14. (505 aa)
	xk	XK-related protein. (481 aa)
	LOC113142913	Spermidine/spermine N1-acetyltransferase family member 2b. (191 aa)
	map1lc3b	Microtubule-associated protein 1 light chain 3 beta. (126 aa)
	ENSMAMP00000022189	Si:ch73-352p4.8. (477 aa)
	ENSMAMP00000021765	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (150 aa)
	atg7	ATG7 autophagy related 7 homolog (S. cerevisiae). (720 aa)
	ENSMAMP00000021671	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (374 aa)
	ENSMAMP00000021418	Zgc:110045. (315 aa)
	vdac3	Voltage-dependent anion channel 3. (323 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	acsl4	Acyl-CoA synthetase long chain family member 4a. (712 aa)
	ENSMAMP00000019766	P53_tetramer domain-containing protein. (193 aa)
	LOC113135018	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (691 aa)
	LOC113140044	Ceruloplasmin; Belongs to the multicopper oxidase family. (1081 aa)
	acsl3	Uncharacterized protein. (719 aa)
	LOC113121833	Transferrin receptor 1b. (752 aa)
	ENSMAMP00000017188	Uncharacterized protein. (316 aa)
	LOC113134491	Acyl-CoA synthetase long chain family member 3b. (710 aa)
	LOC113135961	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (174 aa)
	LOC113146242	Uncharacterized protein. (457 aa)
	LOC113139628	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (723 aa)
	ENSMAMP00000016642	Transferrin receptor 2. (702 aa)
	ENSMAMP00000016421	Si:dkey-202g17.3. (309 aa)
	LOC113124460	Zgc:56235. (281 aa)
	map1lc3a	Microtubule-associated protein 1 light chain 3 alpha. (121 aa)
	slc40a1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (569 aa)
	PCBP2	Poly(rC) binding protein 2. (326 aa)
	ENSMAMP00000014962	Poly(rC) binding protein 4. (500 aa)
	LOC113139308	Acyl-CoA synthetase long chain family member 2. (715 aa)
	LOC113129719	N-acetyltransferase domain-containing protein. (171 aa)
	gclc	Glutamate-cysteine ligase, catalytic subunit. (630 aa)
	ENSMAMP00000013263	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (181 aa)
	slc3a2	Solute carrier family 3 member 2a. (507 aa)
	LOC113141311	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (268 aa)
	LOC113129712	N-acetyltransferase domain-containing protein. (171 aa)
	ENSMAMP00000010388	Solute carrier family 3 member 2b. (483 aa)
	PGPEP1	Pyroglutamyl-peptidase I. (210 aa)
	LOC113134031	Pyroglutamyl-peptidase I. (219 aa)
	LOC113145665	Uncharacterized protein. (586 aa)
	LOC113130482	Solute carrier family 11 member 2. (557 aa)
	ENSMAMP00000007944	Acyl-CoA synthetase long chain family member 5. (675 aa)
	STEAP3	STEAP family member 3, metalloreductase. (510 aa)
	gclm	Glutamate-cysteine ligase, modifier subunit. (273 aa)
	LOC113125452	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	lpcat3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (464 aa)
	slc7a11	Solute carrier family 7 member 11. (503 aa)
	LOC113127817	Uncharacterized protein. (340 aa)
	FTH1	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (177 aa)
	ENSMAMP00000001016	N-acetyltransferase domain-containing protein. (169 aa)
	LOC113125261	N-acetyltransferase domain-containing protein. (169 aa)
	LOC113125260	N-acetyltransferase domain-containing protein. (169 aa)
	gss	Glutathione synthetase. (476 aa)
	ENSMAMP00000000631	Glutathione synthetase. (615 aa)

Your Current Organism:

Mastacembelus armatus

NCBI taxonomy Id: 205130
Other names: M. armatus, Macrognathus armatus, zig-zag eel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSL1	ENSMAMP00000007944	ENSMAMP00000024174	ENSMAMP00000007944	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 5.	0.805
ACSL1	ENSMAMP00000019766	ENSMAMP00000024174	ENSMAMP00000019766	Acyl-CoA synthetase long chain family member 1.	P53_tetramer domain-containing protein.	0.835
ACSL1	LOC113125452	ENSMAMP00000024174	ENSMAMP00000005315	Acyl-CoA synthetase long chain family member 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.835
ACSL1	LOC113128109	ENSMAMP00000024174	ENSMAMP00000026522	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 1a.	0.796
ACSL1	LOC113134491	ENSMAMP00000024174	ENSMAMP00000016961	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 3b.	0.846
ACSL1	LOC113139308	ENSMAMP00000024174	ENSMAMP00000014937	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 2.	0.804
ACSL1	acsl3	ENSMAMP00000024174	ENSMAMP00000017457	Acyl-CoA synthetase long chain family member 1.	Uncharacterized protein.	0.839
ACSL1	acsl4	ENSMAMP00000024174	ENSMAMP00000020169	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 4a.	0.846
ACSL1	acsl6	ENSMAMP00000024174	ENSMAMP00000032105	Acyl-CoA synthetase long chain family member 1.	AMP-binding domain-containing protein.	0.803
ENSMAMP00000000631	ENSMAMP00000013263	ENSMAMP00000000631	ENSMAMP00000013263	Glutathione synthetase.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.766
ENSMAMP00000000631	ENSMAMP00000027755	ENSMAMP00000000631	ENSMAMP00000027755	Glutathione synthetase.	Uncharacterized protein.	0.766
ENSMAMP00000000631	gclc	ENSMAMP00000000631	ENSMAMP00000013337	Glutathione synthetase.	Glutamate-cysteine ligase, catalytic subunit.	0.934
ENSMAMP00000000631	gclm	ENSMAMP00000000631	ENSMAMP00000006065	Glutathione synthetase.	Glutamate-cysteine ligase, modifier subunit.	0.923
ENSMAMP00000001016	LOC113129712	ENSMAMP00000001016	ENSMAMP00000012387	N-acetyltransferase domain-containing protein.	N-acetyltransferase domain-containing protein.	0.637
ENSMAMP00000001016	LOC113129719	ENSMAMP00000001016	ENSMAMP00000013376	N-acetyltransferase domain-containing protein.	N-acetyltransferase domain-containing protein.	0.614
ENSMAMP00000001016	LOC113142913	ENSMAMP00000001016	ENSMAMP00000023273	N-acetyltransferase domain-containing protein.	Spermidine/spermine N1-acetyltransferase family member 2b.	0.771
ENSMAMP00000001016	LOC113142989	ENSMAMP00000001016	ENSMAMP00000026394	N-acetyltransferase domain-containing protein.	Spermidine/spermine N1-acetyltransferase 1.	0.630
ENSMAMP00000007944	ACSL1	ENSMAMP00000007944	ENSMAMP00000024174	Acyl-CoA synthetase long chain family member 5.	Acyl-CoA synthetase long chain family member 1.	0.805
ENSMAMP00000007944	ENSMAMP00000019766	ENSMAMP00000007944	ENSMAMP00000019766	Acyl-CoA synthetase long chain family member 5.	P53_tetramer domain-containing protein.	0.835
ENSMAMP00000007944	ENSMAMP00000024093	ENSMAMP00000007944	ENSMAMP00000024093	Acyl-CoA synthetase long chain family member 5.	AMP-binding domain-containing protein.	0.805