STRINGSTRING
KIQ66225.1 KIQ66225.1 KIQ66319.1 KIQ66319.1 KIQ66340.1 KIQ66340.1 KIQ66810.1 KIQ66810.1 KIQ66845.1 KIQ66845.1 KIQ66858.1 KIQ66858.1 pyrF pyrF pyrD pyrD carB carB carA carA KIQ66912.1 KIQ66912.1 pyrC pyrC pyrB pyrB pyrR pyrR apt apt KIQ64623.1 KIQ64623.1 KIQ64662.1 KIQ64662.1 pyrE pyrE KIQ65061.1 KIQ65061.1 KIQ66059.1 KIQ66059.1 KIQ63855.1 KIQ63855.1 KIQ61712.1 KIQ61712.1 KIQ61839.1 KIQ61839.1 KIQ62040.1 KIQ62040.1 KIQ62220.1 KIQ62220.1 KIQ62230.1 KIQ62230.1 purE purE purK purK KIQ62361.1 KIQ62361.1 KIQ62362.1 KIQ62362.1 KIQ63992.1 KIQ63992.1 add add KIQ62381.1 KIQ62381.1 KIQ62382.1 KIQ62382.1 KIQ62383.1 KIQ62383.1 KIQ63994.1 KIQ63994.1 KIQ62384.1 KIQ62384.1 purH purH purN purN guaA guaA KIQ62474.1 KIQ62474.1 guaB guaB KIQ62556.1 KIQ62556.1 KIQ62669.1 KIQ62669.1 KIQ62768.1 KIQ62768.1 upp upp tadA tadA KIQ62926.1 KIQ62926.1 pyrE-2 pyrE-2 purL purL purQ purQ purS purS purC purC purD purD purA purA purF purF purM purM KIQ64133.1 KIQ64133.1 apt-2 apt-2 KIQ63340.1 KIQ63340.1 KIQ63343.1 KIQ63343.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KIQ66225.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (148 aa)
KIQ66319.1Uridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
KIQ66340.13-carboxy-cis,cis-muconate cycloisomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (470 aa)
KIQ66810.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
KIQ66845.1Nitrate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (466 aa)
KIQ66858.1Inosine-5-monophosphate dehydrogenase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (479 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (279 aa)
pyrDDiguanylate cyclase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (365 aa)
carBCarbamoyl phosphate synthase large subunit; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (1102 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (370 aa)
KIQ66912.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (430 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (330 aa)
pyrRUracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (203 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (184 aa)
KIQ64623.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase M50B family. (374 aa)
KIQ64662.1Chloride channel protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (560 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (177 aa)
KIQ65061.1Cytidine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
KIQ66059.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa)
KIQ63855.1Endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (798 aa)
KIQ61712.1Nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (611 aa)
KIQ61839.1Ribokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
KIQ62040.1Deoxyguanosinetriphosphate triphosphohydrolase; dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (424 aa)
KIQ62220.1Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
KIQ62230.1Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (201 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (175 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (385 aa)
KIQ62361.1Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (276 aa)
KIQ62362.1Phosphomannomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (565 aa)
KIQ63992.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
addAdenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (377 aa)
KIQ62381.1Pyrimidine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa)
KIQ62382.1Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (134 aa)
KIQ62383.1ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family. (421 aa)
KIQ63994.1Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family. (371 aa)
KIQ62384.1ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (530 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (219 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (527 aa)
KIQ62474.1Inosine-5-monophosphate dehydrogenase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (372 aa)
guaBInosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (500 aa)
KIQ62556.1Adenine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
KIQ62669.1ATP-grasp domain protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa)
KIQ62768.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (211 aa)
tadACMP deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (163 aa)
KIQ62926.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the globin family. (138 aa)
pyrE-2Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (178 aa)
purLPhosphoribosylglycinamide synthetase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the tr [...] (751 aa)
purQPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (225 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (84 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (299 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (414 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (528 aa)
purMPhosphoribosylaminoimidazole synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
KIQ64133.15'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (600 aa)
apt-2Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (185 aa)
KIQ63340.1SAICAR synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
KIQ63343.1Purine nucleoside phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (278 aa)
Your Current Organism:
Kitasatospora griseola
NCBI taxonomy Id: 2064
Other names: DSM 43859, IFO 14371, JCM 3339, K. griseola, Kitasatospora sp. OM-5023, NBRC 14371, NRRL B-16229, Streptomyces griseolisporeus, Streptomyces griseolosporeus, VKM Ac-2002, strain AM-9660
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