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thiE thiE hcnC hcnC ThiS ThiS thiG thiG OSY43968.1 OSY43968.1 moaE moaE mog mog moaC2 moaC2 moeA_1 moeA_1 thiC thiC thiD thiD OSY44114.1 OSY44114.1 moaA_1 moaA_1 OSY44117.1 OSY44117.1 cysW_1 cysW_1 potA_1 potA_1 OSY44154.1 OSY44154.1 hemA hemA hemC hemC cysG cysG hemB hemB hemL hemL OSY43457.1 OSY43457.1 hemL2 hemL2 cobM cobM cobL cobL cobT_1 cobT_1 cobK cobK OSY42896.1 OSY42896.1 dthadh dthadh mshD_2 mshD_2 cobJ cobJ cobH cobH CobG CobG ykfC_1 ykfC_1 OSY42904.1 OSY42904.1 TrxB_1 TrxB_1 OSY42906.1 OSY42906.1 dmsA_1 dmsA_1 cobN cobN OSY42337.1 OSY42337.1 moeZ_1 moeZ_1 narK narK nasC nasC nasD_1 nasD_1 nasD_2 nasD_2 nirD nirD OSY42494.1 OSY42494.1 cbiX cbiX OSY42500.1 OSY42500.1 hemH hemH fdhD fdhD OSY41524.1 OSY41524.1 tenA tenA rsgA rsgA paaX_2 paaX_2 bioA bioA trxC trxC bioF1 bioF1 bioD bioD bioB bioB hemE hemE hemY hemY OSY40412.1 OSY40412.1 modA modA fdhF_2 fdhF_2 OSY38895.1 OSY38895.1 cbiM cbiM cbiN cbiN cbiQ cbiQ ecfA3 ecfA3 OSY38900.1 OSY38900.1 nirQ_2 nirQ_2 ynfF ynfF nphR_3 nphR_3 OSY38161.1 OSY38161.1 tetA tetA OSY37867.1 OSY37867.1 cobD-2 cobD-2 cobQ cobQ bchI_2 bchI_2 btuR btuR cobB_3 cobB_3 OSY37884.1 OSY37884.1 sumT sumT cobT_2 cobT_2 cobS cobS bcp_2 bcp_2 cysO cysO thiL_2 thiL_2 OSY35829.1 OSY35829.1 moeA_2 moeA_2 moaB moaB OSY35599.1 OSY35599.1 mmgC_24 mmgC_24 acrC_6 acrC_6 OSY35541.1 OSY35541.1 mhpC_3 mhpC_3 opcR opcR bioN bioN bioM bioM paaJ paaJ yhfT yhfT bioY bioY
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene neighborhood
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gene co-occurrence
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thiEThiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (227 aa)
hcnCHydrogen cyanide synthase subunit HcnC precursor. (386 aa)
ThiSSulfur carrier protein ThiS. (66 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (258 aa)
OSY43968.1CAAX amino terminal protease self- immunity. (288 aa)
moaEMolybdopterin synthase catalytic subunit. (142 aa)
mogMolybdopterin adenylyltransferase. (158 aa)
moaC2Cyclic pyranopterin monophosphate synthase accessory protein 2; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (165 aa)
moeA_1Molybdopterin molybdenumtransferase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (420 aa)
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (545 aa)
thiDHydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (285 aa)
OSY44114.1ThiS family protein. (98 aa)
moaA_1Cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (378 aa)
OSY44117.1Helix-turn-helix domain protein. (134 aa)
cysW_1Sulfate transport system permease protein CysW; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (282 aa)
potA_1Spermidine/putrescine import ATP-binding protein PotA; Belongs to the ABC transporter superfamily. (363 aa)
OSY44154.1Multifunctional thiamine-phosphate pyrophosphorylase/synthase/phosphomethylpyrimidine kinase; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP); Belongs to the TenA family. (224 aa)
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (474 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (318 aa)
cysGSiroheme synthase. (513 aa)
hemBDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (325 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase. (440 aa)
OSY43457.1Cob(I)yrinic acid a,c-diamide adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (195 aa)
hemL2Glutamate-1-semialdehyde 2,1-aminomutase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (399 aa)
cobMPrecorrin-4 C(11)-methyltransferase; Belongs to the precorrin methyltransferase family. (250 aa)
cobLPrecorrin-6Y C(5,15)-methyltransferase [decarboxylating]. (412 aa)
cobT_1Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (573 aa)
cobKPrecorrin-6A reductase. (249 aa)
OSY42896.1D-arabitol-phosphate dehydrogenase. (338 aa)
dthadhD-threo-3-hydroxyaspartate dehydratase. (368 aa)
mshD_2Mycothiol acetyltransferase. (157 aa)
cobJPrecorrin-3B C(17)-methyltransferase. (525 aa)
cobHPrecorrin-8X methylmutase. (183 aa)
CobGFerredoxin-nitrite reductase. (425 aa)
ykfC_1Gamma-D-glutamyl-L-lysine endopeptidase. (345 aa)
OSY42904.1CBS domain protein. (155 aa)
TrxB_1Ferredoxin--NADP reductase. (324 aa)
OSY42906.1Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (104 aa)
dmsA_1Dimethyl sulfoxide reductase DmsA precursor; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (715 aa)
cobNAerobic cobaltochelatase subunit CobN. (1235 aa)
OSY42337.1Nitronate monooxygenase. (325 aa)
moeZ_1Putative adenylyltransferase/sulfurtransferase MoeZ. (390 aa)
narKNitrate/nitrite transporter NarK. (455 aa)
nasCAssimilatory nitrate reductase catalytic subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (713 aa)
nasD_1Nitrite reductase [NAD(P)H]. (472 aa)
nasD_2Nitrite reductase [NAD(P)H]; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (858 aa)
nirDNitrite reductase (NADH) small subunit. (126 aa)
OSY42494.1Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein. (396 aa)
cbiXSirohydrochlorin cobaltochelatase. (236 aa)
OSY42500.1Luciferase-like monooxygenase. (279 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (339 aa)
fdhDFormate dehydrogenase accessory protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (275 aa)
OSY41524.1Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (266 aa)
tenAThiaminase-2; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. (222 aa)
rsgAPutative ribosome biogenesis GTPase RsgA; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (336 aa)
paaX_2Transcriptional repressor PaaX. (298 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (456 aa)
trxCPutative thioredoxin-2. (130 aa)
bioF18-amino-7-oxononanoate synthase 1. (387 aa)
bioDATP-dependent dethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (238 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (335 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (359 aa)
hemYProtoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (478 aa)
OSY40412.1Chlorite dismutase precursor. (234 aa)
modAMolybdate-binding periplasmic protein precursor. (265 aa)
fdhF_2Formate dehydrogenase H; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (772 aa)
OSY38895.1Hypothetical protein. (155 aa)
cbiMCobalt transport protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (233 aa)
cbiNCobalt transport protein CbiN; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (99 aa)
cbiQCobalt transport protein CbiQ. (243 aa)
ecfA3Energy-coupling factor transporter ATP-binding protein EcfA3; Part of an ABC transporter complex. Responsible for energy coupling to the transport system. (296 aa)
OSY38900.1S-adenosyl methyltransferase. (271 aa)
nirQ_2Denitrification regulatory protein NirQ. (624 aa)
ynfFPutative dimethyl sulfoxide reductase chain YnfF precursor; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (711 aa)
nphR_3Transcriptional activator NphR. (321 aa)
OSY38161.1Hypothetical protein. (395 aa)
tetATetracycline resistance protein, class B. (407 aa)
OSY37867.1Precorrin 6A synthase. (271 aa)
cobD-2Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (323 aa)
cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (512 aa)
bchI_2Magnesium-chelatase 38 kDa subunit. (737 aa)
btuRCob(I)yrinic acid a,c-diamide adenosyltransferase. (204 aa)
cobB_3Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (498 aa)
OSY37884.1Cobalamin biosynthesis protein CbiG. (147 aa)
sumTUroporphyrinogen-III C-methyltransferase. (406 aa)
cobT_2Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase. (676 aa)
cobSCobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (297 aa)
bcp_2Putative peroxiredoxin/MT2597. (155 aa)
cysOSulfur carrier protein CysO. (91 aa)
thiL_2Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (333 aa)
OSY35829.1Nitronate monooxygenase. (320 aa)
moeA_2Molybdopterin molybdenumtransferase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (406 aa)
moaBMolybdenum cofactor biosynthesis protein B. (163 aa)
OSY35599.1Major Facilitator Superfamily protein. (392 aa)
mmgC_24Acyl-CoA dehydrogenase. (435 aa)
acrC_6Acryloyl-CoA reductase (NADH). (419 aa)
OSY35541.1Hypothetical protein. (104 aa)
mhpC_32-hydroxy-6-oxononadienedioate/2-hydroxy-6- oxononatrienedioate hydrolase. (285 aa)
opcRHTH-type transcriptional repressor OpcR. (157 aa)
bioNEnergy-coupling factor transporter transmembrane protein BioN. (235 aa)
bioMBiotin transport ATP-binding protein BioM. (225 aa)
paaJ3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (454 aa)
yhfTPutative acyl--CoA ligase YhfT. (408 aa)
bioYBiotin transporter BioY. (192 aa)
Your Current Organism:
Pseudonocardia autotrophica
NCBI taxonomy Id: 2074
Other names: ATCC 19727, Amycolata autotrophica, CIP 107114, DSM 535, IFO 12743, IMSNU 20050, JCM 4348, NBRC 12743, NRRL B-11275, Nocardia autotrophica, P. autotrophica, Streptomyces autotrophicus, VKM Ac-941
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