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| | OSY41505.1 | Glyoxalase-like domain protein. (154 aa) |
| | sbnA_3 | Putative siderophore biosynthesis protein SbnA. (367 aa) |
| | tpa | Taurine--pyruvate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (468 aa) |
| | OSY35119.1 | Hypothetical protein. (391 aa) |
| | cysJ | Sulfite reductase [NADPH] flavoprotein alpha-component. (579 aa) |
| | acsA_8 | Acetyl-coenzyme A synthetase. (629 aa) |
| | OSY35472.1 | Hypothetical protein. (354 aa) |
| | metK_2 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (416 aa) |
| | xecA1_4 | 2-hydroxypropyl-CoM lyase. (387 aa) |
| | xecA1_3 | 2-hydroxypropyl-CoM lyase. (401 aa) |
| | nagI | Gentisate 1,2-dioxygenase. (367 aa) |
| | metX_3 | Homoserine O-acetyltransferase. (271 aa) |
| | thiL_2 | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (333 aa) |
| | xecA1_2 | 2-hydroxypropyl-CoM lyase. (342 aa) |
| | bkdA_2 | 3-methyl-2-oxobutanoate dehydrogenase subunit alpha. (397 aa) |
| | mec | CysO-cysteine peptidase. (197 aa) |
| | cysO | Sulfur carrier protein CysO. (91 aa) |
| | cysM | O-phosphoserine sulfhydrylase. (331 aa) |
| | sbnA_2 | Putative siderophore biosynthesis protein SbnA. (367 aa) |
| | sbnA_1 | Putative siderophore biosynthesis protein SbnA. (367 aa) |
| | acs_2 | Acetyl-coenzyme A synthetase. (642 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (336 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (334 aa) |
| | OSY37575.1 | Hypothetical protein. (245 aa) |
| | mshB_2 | 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase. (270 aa) |
| | folD_4 | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa) |
| | OSY37704.1 | GlcNAc-PI de-N-acetylase. (228 aa) |
| | acsA_7 | Acetyl-coenzyme A synthetase. (565 aa) |
| | ybdK_2 | Carboxylate-amine ligase YbdK. (495 aa) |
| | OSY38503.1 | Putative thiamine biosynthesis protein. (352 aa) |
| | ywrD | Putative gamma-glutamyltransferase YwrD. (601 aa) |
| | MetE_1 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. (386 aa) |
| | OSY38663.1 | Glyoxalase-like domain protein. (262 aa) |
| | folD_3 | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa) |
| | mshB_3 | 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase. (270 aa) |
| | bclA_2 | Benzoate--CoA ligase. (533 aa) |
| | acs_1 | Acetyl-coenzyme A synthetase. (655 aa) |
| | naaB | 5-nitrosalicylic acid 1,2-dioxygenase. (373 aa) |
| | metK_1 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (400 aa) |
| | gshA | Glutamate--cysteine ligase GshA; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. (469 aa) |
| | egtB | Iron(II)-dependent oxidoreductase EgtB; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. (465 aa) |
| | egtC | Amidohydrolase EgtC; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. (252 aa) |
| | egtD | Histidine-specific methyltransferase EgtD; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (340 aa) |
| | cysK | Cysteine synthase. (362 aa) |
| | acsA_6 | Acetyl-coenzyme A synthetase. (657 aa) |
| | OSY39513.1 | Glyoxalase-like domain protein. (136 aa) |
| | folD_2 | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (292 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (355 aa) |
| | OSY39475.1 | Hypothetical protein. (413 aa) |
| | acsA_5 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa) |
| | mshD_8 | Mycothiol acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. (298 aa) |
| | OSY39700.1 | NMT1/THI5 like protein. (350 aa) |
| | metX_2 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (354 aa) |
| | cysD | Sulfate adenylyltransferase subunit 2. (304 aa) |
| | galB | 4-oxalmesaconate hydratase. (242 aa) |
| | acsA_4 | Acetyl-coenzyme A synthetase. (537 aa) |
| | xecA1_1 | 2-hydroxypropyl-CoM lyase. (345 aa) |
| | mdeA_3 | Methionine gamma-lyase. (406 aa) |
| | dxs_1 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (646 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (335 aa) |
| | bioD | ATP-dependent dethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (238 aa) |
| | bioF1 | 8-amino-7-oxononanoate synthase 1. (387 aa) |
| | OSY43891.1 | Glyoxalase-like domain protein. (141 aa) |
| | acsA_1 | Acetyl-coenzyme A synthetase. (518 aa) |
| | acsA_2 | Acetyl-coenzyme A synthetase. (569 aa) |
| | thiE | Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (227 aa) |
| | hcnC | Hydrogen cyanide synthase subunit HcnC precursor. (386 aa) |
| | ThiS | Sulfur carrier protein ThiS. (66 aa) |
| | thiG | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (258 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (545 aa) |
| | thiD | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (285 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (768 aa) |
| | mshA_1 | D-inositol 3-phosphate glycosyltransferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. (424 aa) |
| | OSY44154.1 | Multifunctional thiamine-phosphate pyrophosphorylase/synthase/phosphomethylpyrimidine kinase; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP); Belongs to the TenA family. (224 aa) |
| | hom | Homoserine dehydrogenase. (464 aa) |
| | yitD | Phosphosulfolactate synthase. (261 aa) |
| | OSY43587.1 | Cobalamin-independent synthase, Catalytic domain. (383 aa) |
| | metC | Cystathionine beta-lyase. (371 aa) |
| | bkdA_1 | 3-methyl-2-oxobutanoate dehydrogenase subunit alpha. (353 aa) |
| | mtnA | Methylthioribose-1-phosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family. (347 aa) |
| | OSY43290.1 | NMT1/THI5 like protein. (343 aa) |
| | OSY42888.1 | Putative thiamine biosynthesis protein. (334 aa) |
| | CobG | Ferredoxin-nitrite reductase. (425 aa) |
| | OSY42925.1 | Hypothetical protein. (85 aa) |
| | cbs | Putative cystathionine beta-synthase. (455 aa) |
| | metB | Cystathionine gamma-synthase. (381 aa) |
| | mshB_1 | 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway. (295 aa) |
| | moeZ_1 | Putative adenylyltransferase/sulfurtransferase MoeZ. (390 aa) |
| | OSY42526.1 | Glyoxalase-like domain protein. (141 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (456 aa) |
| | bclA_1 | Benzoate--CoA ligase. (544 aa) |
| | folD_1 | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (279 aa) |
| | OSY41050.1 | Omega-amino acid--pyruvate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (416 aa) |
| | tenA | Thiaminase-2; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. (222 aa) |
| | metX_1 | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (378 aa) |
| | OSY41199.1 | Hypothetical protein. (139 aa) |
| | OSY41183.1 | Glyoxalase-like domain protein. (167 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta. (501 aa) |
| | acsA_3 | Acetyl-coenzyme A synthetase. (665 aa) |
| | OSY42158.1 | Hypothetical protein. (167 aa) |
| | OSY41781.1 | Glyoxalase-like domain protein. (126 aa) |
| | mshC | L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. (413 aa) |
| | metH | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1210 aa) |
