STRINGSTRING
SAG0011 SAG0011 pscB pscB SAG0031 SAG0031 rpoE rpoE SAG0159 SAG0159 SAG0167 SAG0167 proC proC proB proB proA proA rsmH rsmH ftsL ftsL pbpX pbpX mraY mraY pbp1A pbp1A recU recU SAG0300 SAG0300 gpsB gpsB SAG0303 SAG0303 mapZ mapZ SAG0372 SAG0372 SAG0373 SAG0373 SAG0374 SAG0374 SAG0375 SAG0375 trmB trmB SAG0470 SAG0470 SAG0473 SAG0473 SAG0474 SAG0474 murD murD murG murG divIB divIB ftsA ftsA ftsZ ftsZ SAG0480 SAG0480 ylmF ylmF SAG0482 SAG0482 ylmH ylmH SAG0484 SAG0484 ftsE ftsE ftsX ftsX SAG0537 SAG0537 SAG0539 SAG0539 SAG0541 SAG0541 rodA rodA ezrA ezrA SAG0677 SAG0677 ftsW ftsW SAG0765 SAG0765 ddl ddl murF murF SAG0801 SAG0801 prsA prsA murA-1 murA-1 murB murB SAG1380 SAG1380 SAG1381 SAG1381 cmk cmk SAG1386 SAG1386 SAG1387 SAG1387 murE murE rsuA rsuA SAG1509 SAG1509 mltG mltG SAG1614 SAG1614 murC murC SAG1616 SAG1616 SAG1617 SAG1617 SAG1619 SAG1619 der der dnaI dnaI SAG1622 SAG1622 nrdR nrdR SAG1760 SAG1760 pbp2A pbp2A SAG2092 SAG2092 SAG2148 SAG2148
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SAG0011Cell division protein DivIC, putative; Similar to OMNI:NTL01SPL0011; identified by sequence similarity; putative. (123 aa)
pscBpcsB protein; Similar to GP:12667037; identified by sequence similarity; putative. (447 aa)
SAG0031Peptidase, M23/M37 family; Identified by match to PFAM protein family HMM PF01551. (299 aa)
rpoEDNA-directed RNA polymerase, delta subunit, putative; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family. (191 aa)
SAG0159Penicillin-binding protein 1B, putative; Identified by match to PFAM protein family HMM PF00905. (765 aa)
SAG0167Conserved hypothetical protein; Identified by Glimmer2; putative. (324 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (256 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (267 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (417 aa)
rsmHConserved hypothetical protein TIGR00006; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (298 aa)
ftsLCell division protein FtsL, putative; Essential cell division protein; Belongs to the FtsL family. (108 aa)
pbpXPenicillin-binding protein 2X; Identified by match to PFAM protein family HMM PF00905. (752 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (336 aa)
pbp1APenicillin-binding protein 1A; Identified by match to PFAM protein family HMM PF00905. (750 aa)
recURecombination protein U; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family. (199 aa)
SAG0300Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the UPF0398 family. (172 aa)
gpsBConserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. (110 aa)
SAG0303Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the methyltransferase superfamily. (384 aa)
mapZConserved hypothetical protein; Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning. (487 aa)
SAG0372Hypothetical protein; Identified by Glimmer2; putative. (85 aa)
SAG0373ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (241 aa)
SAG0374ABC transporter, permease protein; Similar to OMNI:NTL01SPL1360; identified by sequence similarity; putative. (344 aa)
SAG0375Conserved hypothetical protein; Identified by Glimmer2; putative. (266 aa)
trmBConserved hypothetical protein TIGR00091; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (211 aa)
SAG0470Conserved hypothetical protein; Identified by Glimmer2; putative. (69 aa)
SAG0473Elongation factor Tu family protein; Identified by match to PFAM protein family HMM PF00009. (613 aa)
SAG0474Conserved hypothetical protein; Identified by Glimmer2; putative. (81 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (451 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (358 aa)
divIBCell division protein DivIB, putative; Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex; Belongs to the FtsQ/DivIB family. DivIB subfamily. (378 aa)
ftsACell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (429 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (426 aa)
SAG0480ylmE protein, putative; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (224 aa)
ylmFylmF protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. (201 aa)
SAG0482YGGT family protein; Identified by match to PFAM protein family HMM PF02325. (84 aa)
ylmHylmH protein; Identified by match to PFAM protein family HMM PF01479. (262 aa)
SAG0484Cell division protein DivIVA, putative; Similar to OMNI:SP1661; identified by sequence similarity; putative. (256 aa)
ftsECell division ABC transporter, ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. (230 aa)
ftsXCell division ABC transporter, permease protein FtsX; Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation. Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (309 aa)
SAG0537DHH family protein; Identified by match to PFAM protein family HMM PF01368. (311 aa)
SAG0539Flavodoxin; Identified by match to PFAM protein family HMM PF00258. (147 aa)
SAG0541Voltage-gated chloride channel family protein; Identified by match to PFAM protein family HMM PF00654. (398 aa)
rodARod shape-determining protein RodA, putative; Identified by match to PFAM protein family HMM PF01098; Belongs to the SEDS family. (401 aa)
ezrASeptation ring formation regulator EzrA, putative; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. (574 aa)
SAG0677Hypothetical protein; Identified by Glimmer2; putative; The product of this gene was detected by Western blot analysis. For details on the method see Tettelin et al. 2002. (1062 aa)
ftsWCell division protein, FtsW/RodA/SpoVE family; Identified by match to PFAM protein family HMM PF01098; Belongs to the SEDS family. (422 aa)
SAG0765Penicillin-binding protein 2b; Identified by match to PFAM protein family HMM PF00905. (681 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation. (348 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (455 aa)
SAG0801Ribosomal small subunit pseudouridine synthase A, putative; Identified by match to PFAM protein family HMM PF00849; Belongs to the pseudouridine synthase RsuA family. (239 aa)
prsAProtease maturation protein, putative; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins. (309 aa)
murA-1UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (300 aa)
SAG1380Conserved hypothetical protein; Identified by Glimmer2; putative. (385 aa)
SAG1381Sulfatase; Identified by match to PFAM protein family HMM PF00884. (714 aa)
cmkCytidylate kinase; Identified by match to PFAM protein family HMM PF02224. (227 aa)
SAG1386Conserved hypothetical protein; Identified by Glimmer2; putative. (174 aa)
SAG1387Ferredoxin, 4Fe-4S. (65 aa)
murEUDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (484 aa)
rsuARibosomal small subunit pseudouridine synthase A; Identified by match to PFAM protein family HMM PF00849; Belongs to the pseudouridine synthase RsuA family. (240 aa)
SAG1509Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the UPF0346 family. (71 aa)
mltGConserved hypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (600 aa)
SAG1614Acetyltransferase, GNAT family; Identified by match to PFAM protein family HMM PF00583. (167 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (443 aa)
SAG1616Conserved hypothetical protein; Identified by Glimmer2; putative. (205 aa)
SAG1617Hypothetical protein; Identified by Glimmer2; putative. (32 aa)
SAG1619IS1548, transposase; Identified by match to PFAM protein family HMM PF01609. (377 aa)
derPhosphoglycerate dehydrogenase-related protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (436 aa)
dnaIPrimosomal protein DnaI. (300 aa)
SAG1622Conserved hypothetical protein; Identified by Glimmer2; putative. (391 aa)
nrdRConserved hypothetical protein TIGR00244; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (159 aa)
SAG1760Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the UPF0356 family. (76 aa)
pbp2APenicillin-binding protein 2A; Identified by match to PFAM protein family HMM PF00905. (773 aa)
SAG2092Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the ArsC family. (132 aa)
SAG2148LysM domain protein; Identified by match to PFAM protein family HMM PF01476. (179 aa)
Your Current Organism:
Streptococcus agalactiae
NCBI taxonomy Id: 208435
Other names: S. agalactiae 2603V/R, Streptococcus agalactiae 2603V/R, Streptococcus agalactiae str. 2603V/R
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