(34 nodes) Ribonucleoside monophosphate metabolic process, and 5-Nucleotidase/apyrase network (Streptococcus agalactiae)

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	purC	Phosphoribosylaminoimidazole-succinocarboxamide synthase; Identified by match to PFAM protein family HMM PF01259; Belongs to the SAICAR synthetase family. (234 aa)
	SAG0025	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769. (1241 aa)
	purF	Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (484 aa)
	purM	Phosphoribosylformylglycinamidine cyclo-ligase; Identified by match to PFAM protein family HMM PF00586. (340 aa)
	purN	Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (182 aa)
	purH	Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by match to PFAM protein family HMM PF01808. (515 aa)
	purD	Phosphoribosylamine--glycine ligase; Identified by match to PFAM protein family HMM PF01071; Belongs to the GARS family. (421 aa)
	purE	Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa)
	purK	Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (363 aa)
	purB	Adenylosuccinate lyase; Identified by match to PFAM protein family HMM PF00206; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (432 aa)
	adk	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (212 aa)
	gmk	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (209 aa)
	pyrDA	Dihydroorotate dehydrogenase A; Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (310 aa)
	add	Adenosine deaminase, putative; Identified by match to PFAM protein family HMM PF00962; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (340 aa)
	guaA	GMP synthase; Catalyzes the synthesis of GMP from XMP. (520 aa)
	carB	Carbamoyl-phosphate synthase, large subunit; Identified by match to PFAM protein family HMM PF00289. (1060 aa)
	carA-1	Carbamoyl-phosphate synthase, small subunit; Identified by match to PFAM protein family HMM PF00117; Belongs to the CarA family. (358 aa)
	pyrB	Aspartate carbamoyltransferase; Identified by match to PFAM protein family HMM PF00185; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (307 aa)
	pyrC	Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (430 aa)
	pyrE	Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (209 aa)
	pyrF	Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (233 aa)
	pbuX	Xanthine permease; Identified by match to PFAM protein family HMM PF00860. (424 aa)
	xpt	Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (193 aa)
	guaC	Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (327 aa)
	uraA	Uracil permease; Identified by match to PFAM protein family HMM PF00860. (441 aa)
	apt	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa)
	SAG1333	Identified by match to PFAM protein family HMM PF00149; Belongs to the 5'-nucleotidase family. (690 aa)
	SAG1362	Carbamoyl-phosphate synthase, large subunit, putative; Identified by match to PFAM protein family HMM PF02787. (532 aa)
	carA-2	Carbamoyl-phosphate synthase, small subunit; Identified by match to PFAM protein family HMM PF00117; Belongs to the CarA family. (356 aa)
	pyrR	Pyrimidine operon regulatory protein; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (173 aa)
	purR	Pur operon repressor; Identified by match to PFAM protein family HMM PF00156. (270 aa)
	purA	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
	cpdB	2',3'-cyclic-nucleotide 2'-phosphodiesterase; Identified by match to PFAM protein family HMM PF00149. (800 aa)
	guaB	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (493 aa)

Your Current Organism:

Streptococcus agalactiae

NCBI taxonomy Id: 208435
Other names: S. agalactiae 2603V/R, Streptococcus agalactiae 2603V/R, Streptococcus agalactiae str. 2603V/R

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SAG0025	SAG1362	SAG0025	SAG1362	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Carbamoyl-phosphate synthase, large subunit, putative; Identified by match to PFAM protein family HMM PF02787.	0.923
SAG0025	apt	SAG0025	SAG1205	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.711
SAG0025	carA-1	SAG0025	SAG1043	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Carbamoyl-phosphate synthase, small subunit; Identified by match to PFAM protein family HMM PF00117; Belongs to the CarA family.	0.979
SAG0025	carA-2	SAG0025	SAG1363	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Carbamoyl-phosphate synthase, small subunit; Identified by match to PFAM protein family HMM PF00117; Belongs to the CarA family.	0.979
SAG0025	carB	SAG0025	SAG1042	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Carbamoyl-phosphate synthase, large subunit; Identified by match to PFAM protein family HMM PF00289.	0.923
SAG0025	gmk	SAG0025	SAG0313	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.673
SAG0025	guaA	SAG0025	SAG0967	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.990
SAG0025	guaB	SAG0025	SAG2159	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.877
SAG0025	guaC	SAG0025	SAG1087	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.	0.712
SAG0025	pbuX	SAG0025	SAG1085	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Xanthine permease; Identified by match to PFAM protein family HMM PF00860.	0.688
SAG0025	purA	SAG0025	SAG1818	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.977
SAG0025	purB	SAG0025	SAG0047	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Adenylosuccinate lyase; Identified by match to PFAM protein family HMM PF00206; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.999
SAG0025	purC	SAG0025	SAG0024	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Phosphoribosylaminoimidazole-succinocarboxamide synthase; Identified by match to PFAM protein family HMM PF01259; Belongs to the SAICAR synthetase family.	0.999
SAG0025	purD	SAG0025	SAG0043	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Phosphoribosylamine--glycine ligase; Identified by match to PFAM protein family HMM PF01071; Belongs to the GARS family.	0.999
SAG0025	purE	SAG0025	SAG0044	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).	0.999
SAG0025	purF	SAG0025	SAG0026	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.999
SAG0025	purH	SAG0025	SAG0030	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by match to PFAM protein family HMM PF01808.	0.999
SAG0025	purK	SAG0025	SAG0045	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).	0.999
SAG0025	purM	SAG0025	SAG0027	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Phosphoribosylformylglycinamidine cyclo-ligase; Identified by match to PFAM protein family HMM PF00586.	0.999
SAG0025	purN	SAG0025	SAG0028	Phosphoribosylformylglycinamidine synthase, putative; Identified by match to PFAM protein family HMM PF02769.	Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.	0.999