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prsA-1 prsA-1 acpP-1 acpP-1 adhE adhE adhP adhP SAG0112 SAG0112 SAG0342 SAG0342 SAG0343 SAG0343 fabH fabH acpP acpP fabK fabK fabD fabD fabG fabG fabF fabF accB accB fabZ fabZ accC accC accD accD accA accA SAG0383 SAG0383 SAG0466 SAG0466 SAG0521 SAG0521 SAG0523 SAG0523 SAG0662 SAG0662 cylD cylD cylG cylG SAG0665 SAG0665 SAG0666 SAG0666 cylA cylA cylB cylB cylE cylE cylF cylF cylI cylI cylJ cylJ cylK cylK SAG0674 SAG0674 SAG0675 SAG0675 SAG0676 SAG0676 SAG0679 SAG0679 SAG0680 SAG0680 SAG0681 SAG0681 SAG0785 SAG0785 SAG0786 SAG0786 SAG0878 SAG0878 SAG0879 SAG0879 SAG0880 SAG0880 SAG0881 SAG0881 lplA-1 lplA-1 coaA coaA lplA-2 lplA-2 SAG1057 SAG1057 SAG1058 SAG1058 SAG1059 SAG1059 SAG1060 SAG1060 SAG1061 SAG1061 SAG1062 SAG1062 SAG1063 SAG1063 SAG1064 SAG1064 SAG1091 SAG1091 prsA-2 prsA-2 SAG1237 SAG1237 merA-1 merA-1 gor gor adh adh SAG1673 SAG1673 acpS acpS SAG1756 SAG1756 SAG1826 SAG1826 SAG2153 SAG2153 SAG2154 SAG2154
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
prsA-1Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (322 aa)
acpP-1Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (79 aa)
adhEAldehyde-alcohol dehydrogenase; Identified by match to PFAM protein family HMM PF00171; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (880 aa)
adhPAlcohol dehydrogenase, propanol-preferring; Identified by match to PFAM protein family HMM PF00107. (338 aa)
SAG0112Pyridine nucleotide-disulphide oxidoreductase family protein; Identified by match to PFAM protein family HMM PF00070. (439 aa)
SAG0342Identified by match to PFAM protein family HMM PF00378. (263 aa)
SAG0343Transcriptional regulator, MarR family; Identified by match to PFAM protein family HMM PF01047. (144 aa)
fabH3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (323 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (74 aa)
fabKEnoyl-(acyl-carrier-protein) reductase II; Identified by match to PFAM protein family HMM PF03060. (319 aa)
fabDMalonyl CoA-acyl carrier protein transacylase; Identified by match to PFAM protein family HMM PF00698. (308 aa)
fabG3-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa)
fabF3-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (410 aa)
accBacetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (166 aa)
fabZ(3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (140 aa)
accCacetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (456 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (291 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (257 aa)
SAG0383Protein of unknown function/lipoprotein, putative; Similar to OMNI:NTL01SPL1351; identified by sequence similarity; putative; The product of this gene was detected by Western blot analysis. For details on the method see Tettelin et al. 2002. (334 aa)
SAG0466Thiolase; Identified by match to PFAM protein family HMM PF00108; Belongs to the thiolase-like superfamily. Thiolase family. (371 aa)
SAG0521Carboxymethylenebutenolidase-related protein; Similar to OMNI:EF0274; identified by sequence similarity; putative. (236 aa)
SAG0523Oxidoreductase, short chain dehydrogenase/reductase family; Identified by match to PFAM protein family HMM PF00106. (254 aa)
SAG0662cylX protein; Similar to GP:4886770; identified by sequence similarity; putative. (101 aa)
cylDcylD protein. (282 aa)
cylGcylG protein; Identified by match to PFAM protein family HMM PF00106. (240 aa)
SAG0665Acyl carrier protein AcpC. (101 aa)
SAG0666cylZ protein; Identified by match to PFAM protein family HMM PF01377. (158 aa)
cylAcylA protein; Identified by match to PFAM protein family HMM PF00005. (309 aa)
cylBcylB protein. (292 aa)
cylEcylE protein; Similar to GP:4886777; identified by sequence similarity; putative. (667 aa)
cylFcylF protein; Identified by match to PFAM protein family HMM PF01571; Belongs to the GcvT family. (317 aa)
cylIcylI protein; Identified by match to PFAM protein family HMM PF00109; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (731 aa)
cylJcylJ protein; Similar to GP:6007854; identified by sequence similarity; putative. (403 aa)
cylKcylK protein; Similar to GP:6007855; identified by sequence similarity; putative. (191 aa)
SAG0674Hypothetical protein; Identified by Glimmer2; putative. (113 aa)
SAG0675Secreted protein, putative; Similar to SP:P16952; identified by sequence similarity; putative. (171 aa)
SAG0676Proteinase, putative; Identified by match to PFAM protein family HMM PF00082; Belongs to the peptidase S8 family. (885 aa)
SAG0679Protein of unknown function; The product of this gene was detected by Western blot analysis. For details on the method see Tettelin et al. 2002. (343 aa)
SAG0680Protein of unknown function; The product of this gene was detected by Western blot analysis. For details on the method see Tettelin et al. 2002. (339 aa)
SAG0681Conserved domain protein. (353 aa)
SAG0785Conserved hypothetical protein; Identified by Glimmer2; putative. (330 aa)
SAG0786Conserved domain protein. (242 aa)
SAG0878Acetoin dehydrogenase, thymine PPi dependent, E1 component, alpha subunit; Identified by match to PFAM protein family HMM PF00676. (322 aa)
SAG0879Acetoin dehydrogenase, thymine PPi dependent, E1 component, beta subunit; Identified by match to PFAM protein family HMM PF02779. (332 aa)
SAG0880Acetoin dehydrogenase, thymine PPi dependent, E2 component, dihydrolipoamide acetyltransferase; Identified by match to PFAM protein family HMM PF00198. (462 aa)
SAG0881Acetoin dehydrogenase, thymine PPi dependent, E3 component, dihydrolipoamide dehydrogenase; Identified by match to PFAM protein family HMM PF00070. (585 aa)
lplA-1Lipoate-protein ligase A; Identified by match to PFAM protein family HMM PF02539. (329 aa)
coaAPantothenate kinase; Identified by match to PFAM protein family HMM PF00485. (306 aa)
lplA-2Lipoate-protein ligase A; Identified by match to PFAM protein family HMM PF02539. (339 aa)
SAG1057Conserved hypothetical protein; Identified by Glimmer2; putative. (292 aa)
SAG1058Conserved hypothetical protein; Identified by Glimmer2; putative. (272 aa)
SAG1059Glycine cleavage system H protein, putative; Identified by match to PFAM protein family HMM PF01597. (110 aa)
SAG1060Identified by match to PFAM protein family HMM PF00296. (328 aa)
SAG1061Oxidoreductase, FMN-binding; Identified by match to PFAM protein family HMM PF00724. (399 aa)
SAG1062Conserved hypothetical protein; Identified by Glimmer2; putative. (282 aa)
SAG1063Flavoprotein-related protein; Similar to GB:L77117 PID:1591587; identified by sequence similarity; putative. (228 aa)
SAG1064Identified by match to PFAM protein family HMM PF02441. (180 aa)
SAG1091Oxidoreductase, short chain dehydrogenase/reductase family; Identified by match to PFAM protein family HMM PF00106; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (216 aa)
prsA-2Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa)
SAG1237Hypothetical protein; Identified by Glimmer2; putative. (444 aa)
merA-1Mercuric reductase; Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0). Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (546 aa)
gorGlutathione reductase; Identified by match to PFAM protein family HMM PF00070. (449 aa)
adhAlcohol dehydrogenase, zinc-containing; Identified by match to PFAM protein family HMM PF00107. (351 aa)
SAG1673Identified by match to PFAM protein family HMM PF00725. (321 aa)
acpSHolo-(acyl-carrier-protein) synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (119 aa)
SAG1756Conserved hypothetical protein; Identified by Glimmer2; putative. (341 aa)
SAG1826Identified by match to PFAM protein family HMM PF01712. (213 aa)
SAG2153Peptidase, M16 family; Identified by match to PFAM protein family HMM PF00675. (427 aa)
SAG2154Conserved hypothetical protein; Identified by Glimmer2; putative. (414 aa)
Your Current Organism:
Streptococcus agalactiae
NCBI taxonomy Id: 208435
Other names: S. agalactiae 2603V/R, Streptococcus agalactiae 2603V/R, Streptococcus agalactiae str. 2603V/R
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