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smc smc dnaA dnaA ychF ychF mfd mfd tilS tilS ftsH ftsH prsA-1 prsA-1 purC purC purM purM purD purD purK purK ruvB ruvB adk adk grpE grpE dnaK dnaK dnaJ dnaJ pyrG pyrG radA radA gltX gltX rbsA rbsA rbsK rbsK SAG0122 SAG0122 argG argG SAG0135 SAG0135 SAG0141 SAG0141 SAG0151 SAG0151 SAG0152 SAG0152 ispE ispE SAG0155 SAG0155 tyrS tyrS ackA ackA lytS lytS SAG0190 SAG0190 SAG0191 SAG0191 cysS cysS SAG0244 SAG0244 SAG0260 SAG0260 glyQ glyQ glyS glyS glpK glpK SAG0280 SAG0280 proB proB cshB cshB SAG0292 SAG0292 nadE nadE SAG0308 SAG0308 gmk gmk priA priA SAG0319 SAG0319 SAG0321 SAG0321 SAG0336 SAG0336 SAG0339 SAG0339 accC accC accD accD accA accA serS serS SAG0373 SAG0373 SAG0385 SAG0385 SAG0403 SAG0403 nrdE-1 nrdE-1 valS valS asnA asnA coaD coaD SAG0455 SAG0455 SAG0460 SAG0460 SAG0461 SAG0461 murD murD ileS ileS SAG0488 SAG0488 SAG0492 SAG0492 nnrD nnrD recN recN SAG0514 SAG0514 ftsE ftsE dinG dinG asnS asnS SAG0531 SAG0531 vex2 vex2 gyrB gyrB aroK aroK SAG0659 SAG0659 cylA cylA SAG0684 SAG0684 SAG0688 SAG0688 thrS thrS SAG0718 SAG0718 SAG0730 SAG0730 hprK hprK lysS lysS ddl ddl murF murF SAG0774 SAG0774 cshA cshA alaS alaS nrdE-2 nrdE-2 SAG0825 SAG0825 udk udk dnaX dnaX birA birA metK metK SAG0837 SAG0837 thiM thiM SAG0851 SAG0851 glgC glgC atpA atpA atpG atpG atpD atpD atpC atpC pheS pheS pheT pheT rexB rexB rexA rexA SAG0877 SAG0877 lplA-1 lplA-1 SAG0884 SAG0884 dacA dacA ndk ndk SAG0911 SAG0911 SAG0933 SAG0933 pfk pfk pyk pyk SAG0948 SAG0948 coaA coaA SAG0955 SAG0955 gyrA gyrA guaA guaA SAG0974 SAG0974 pstB1 pstB1 pstB2 pstB2 SAG0997 SAG0997 SAG1004 SAG1004 SAG1008 SAG1008 SAG1033 SAG1033 carB carB carA-1 carA-1 SAG1049 SAG1049 fhs fhs lplA-2 lplA-2 SAG1070 SAG1070 SAG1071 SAG1071 tdk tdk nadK nadK prsA-2 prsA-2 potA potA folK folK folC folC thrB thrB pcrA pcrA parC parC parE parE cpsD cpsD SAG1187 SAG1187 miaA miaA SAG1257 SAG1257 SAG1262 SAG1262 SAG1280 SAG1280 SAG1303 SAG1303 clpX clpX SAG1320 SAG1320 SAG1324 SAG1324 mvaD mvaD SAG1326 SAG1326 SAG1337 SAG1337 SAG1338 SAG1338 SAG1340 SAG1340 cca cca fruK fruK SAG1360 SAG1360 SAG1362 SAG1362 carA-2 carA-2 thiI thiI cmk cmk murE murE SAG1392 SAG1392 secA2 secA2 uvrB uvrB SAG1467 SAG1467 SAG1487 SAG1487 coaE coaE dgkA dgkA SAG1507 SAG1507 pyrH pyrH SAG1514 SAG1514 SAG1515 SAG1515 ftsK ftsK SAG1532 SAG1532 metG metG tmk tmk livF livF livG livG murC murC SAG1618 SAG1618 dnaI dnaI nrdR nrdR SAG1633 SAG1633 metN metN tmcAL tmcAL nadD nadD gatB gatB gatA gatA gatC gatC ppdK ppdK SAG1671 SAG1671 recG recG secA secA uvrA uvrA mutS2 mutS2 recD2 recD2 cydC cydC SAG1740 SAG1740 pgk pgk SAG1775 SAG1775 dltA dltA dltS dltS SAG1797 SAG1797 gshAB gshAB SAG1826 SAG1826 SAG1828 SAG1828 SAG1870 SAG1870 dnaC-1 dnaC-1 proS proS SAG1925 SAG1925 lacC lacC SAG1940 SAG1940 SAG1955 SAG1955 pstB3 pstB3 SAG1978 SAG1978 SAG1980 SAG1980 SAG2014 SAG2014 SAG2018 SAG2018 SAG2027 SAG2027 SAG2035 SAG2035 leuS leuS groEL groEL groES groES SAG2076 SAG2076 nrdD nrdD recA recA ruvA ruvA hexB hexB hexA hexA argS argS aspS aspS hisS hisS SAG2119 SAG2119 SAG2129 SAG2129 dnaC-2 dnaC-2 trmU trmU ecfA2 ecfA2 ecfA1 ecfA1 recF recF trpS trpS SAG2171 SAG2171
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query proteins and first shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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smcChromosome segregation SMC protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1179 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (453 aa)
ychFGTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (371 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1165 aa)
tilSMesJ/Ycf62 family protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (424 aa)
ftsHCell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (658 aa)
prsA-1Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (322 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Identified by match to PFAM protein family HMM PF01259; Belongs to the SAICAR synthetase family. (234 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; Identified by match to PFAM protein family HMM PF00586. (340 aa)
purDPhosphoribosylamine--glycine ligase; Identified by match to PFAM protein family HMM PF01071; Belongs to the GARS family. (421 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (363 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (332 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (212 aa)
grpEHeat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] (190 aa)
dnaKdnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. (609 aa)
dnaJdnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] (379 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (534 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (454 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (484 aa)
rbsARibose ABC transporter, ATP-binding protein; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family. (492 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (303 aa)
SAG0122ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (228 aa)
argGArgininosuccinate synthase; Identified by match to PFAM protein family HMM PF00764; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (396 aa)
SAG0135Amino acid ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (246 aa)
SAG0141ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (256 aa)
SAG0151Oligopeptide ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005; Belongs to the ABC transporter superfamily. (348 aa)
SAG0152Oligopeptide ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005; Belongs to the ABC transporter superfamily. (310 aa)
ispE4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily. (283 aa)
SAG0155Zinc ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (236 aa)
tyrStyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (419 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
lytSSensor histidine kinase, putative; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. (581 aa)
SAG0190Peptide ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (267 aa)
SAG0191Peptide ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (208 aa)
cysScysteinyl-tRNA synthetase; Identified by match to PFAM protein family HMM PF01406; Belongs to the class-I aminoacyl-tRNA synthetase family. (447 aa)
SAG0244Amino acid ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (381 aa)
SAG0260ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (238 aa)
glyQglycyl-tRNA synthetase, alpha subunit; Identified by match to PFAM protein family HMM PF02091. (304 aa)
glySglycyl-tRNA synthetase, beta subunit; Identified by match to PFAM protein family HMM PF02092. (679 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (502 aa)
SAG0280ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (244 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (267 aa)
cshBATP-dependent RNA helicase, DEAD/DEAH box family; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (447 aa)
SAG0292Amino acid ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (247 aa)
nadENAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (273 aa)
SAG0308ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (298 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (209 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (796 aa)
SAG0319Serine/threonine protein kinase; Identified by match to PFAM protein family HMM PF00069. (651 aa)
SAG0321Sensor histidine kinase, putative; Identified by match to PFAM protein family HMM PF02518. (339 aa)
SAG0336Helicase, putative; Identified by match to PFAM protein family HMM PF00270. (429 aa)
SAG0339Identified by match to PFAM protein family HMM PF00696; Belongs to the aspartokinase family. (450 aa)
accCacetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (456 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (291 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (257 aa)
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa)
SAG0373ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (241 aa)
SAG0385Copper-transporter ATPase CopA; Identified by match to PFAM protein family HMM PF00122. (744 aa)
SAG0403Identified by match to PFAM protein family HMM PF01812; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (175 aa)
nrdE-1Ribonucleoside-diphosphate reductase 2, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (721 aa)
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (883 aa)
asnAAspartate--ammonia ligase; Identified by match to TIGR protein family HMM TIGR00669. (330 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (161 aa)
SAG0455Conserved hypothetical protein; Identified by Glimmer2; putative. (357 aa)
SAG0460ABC transporter, ATP-binding/permease protein; Identified by match to PFAM protein family HMM PF00005. (581 aa)
SAG0461ABC transporter, ATP-binding/permease protein; Identified by match to PFAM protein family HMM PF00005. (579 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (451 aa)
ileSisoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). (930 aa)
SAG0488ATP-dependent Clp protease, ATP-binding subunit; Identified by match to PFAM protein family HMM PF00004; Belongs to the ClpA/ClpB family. (753 aa)
SAG0492Amino acid ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (244 aa)
nnrDProtein of unknown function; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (278 aa)
recNDNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (552 aa)
SAG0514Cation-transporting ATPase, E1-E2 family; Identified by match to PFAM protein family HMM PF00122. (894 aa)
ftsECell division ABC transporter, ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. (230 aa)
dinGDNA polymerase III, epsilon subunit/ATP-dependent helicase DinG; 3'-5' exonuclease. (835 aa)
asnSasparaginyl-tRNA synthetase; Identified by match to PFAM protein family HMM PF00152. (448 aa)
SAG0531Conserved hypothetical protein; Displays ATPase and GTPase activities. (296 aa)
vex2ABC transporter, ATP-binding protein Vexp2; Identified by match to PFAM protein family HMM PF00005. (218 aa)
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (650 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (170 aa)
SAG0659ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (330 aa)
cylAcylA protein; Identified by match to PFAM protein family HMM PF00005. (309 aa)
SAG0684ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (223 aa)
SAG0688ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (218 aa)
thrSthreonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (647 aa)
SAG0718Amino acid ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (251 aa)
SAG0730ABC transporter, ATP-binding protein; Similar to OMNI:NTL01SPL0429; identified by sequence similarity; putative. (42 aa)
hprKHPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable car [...] (311 aa)
lysSlysyl-tRNA synthetase; Identified by match to PFAM protein family HMM PF00152; Belongs to the class-II aminoacyl-tRNA synthetase family. (496 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation. (348 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (455 aa)
SAG0774ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. (244 aa)
cshAATP-dependent RNA helicase, DEAD/DEAH box family; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. (528 aa)
alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (872 aa)
nrdE-2Ribonucleoside-diphosphate reductase 2, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (719 aa)
SAG0825ATP-dependent RNA helicase, DEAD/DEAH box family; Identified by match to PFAM protein family HMM PF00270. (360 aa)
udkUridine kinase; Identified by match to PFAM protein family HMM PF00485. (209 aa)
dnaXDNA polymerase III, gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (554 aa)
birAbiotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (311 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (398 aa)
SAG0837ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (428 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (256 aa)
SAG0851bmrU protein, putative; Identified by match to PFAM protein family HMM PF00781. (339 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (379 aa)
atpAATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (501 aa)
atpGATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (293 aa)
atpDATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (468 aa)
atpCATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (137 aa)
pheSphenylalanyl-tRNA synthetase, alpha subunit; Identified by match to PFAM protein family HMM PF01409; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (346 aa)
pheTphenylalanyl-tRNA synthetase, beta subunit; Identified by match to PFAM protein family HMM PF01588; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (801 aa)
rexBExonuclease RexB; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity; Belongs to the helicase family. AddB/RexB type 2 subfamily. (1077 aa)
rexAExonuclease RexA; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities; Belongs to the helicase family. AddA subfamily. (1207 aa)
SAG0877ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (636 aa)
lplA-1Lipoate-protein ligase A; Identified by match to PFAM protein family HMM PF02539. (329 aa)
SAG0884Mur ligase family protein. (447 aa)
dacAConserved hypothetical protein TIGR00159; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (283 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (138 aa)
SAG0911Cation-transporting ATPase, E1-E2 family; Identified by match to PFAM protein family HMM PF00122. (930 aa)
SAG0933Identified by match to PFAM protein family HMM PF01580. (461 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (340 aa)
pykPyruvate kinase; Identified by match to PFAM protein family HMM PF00224; Belongs to the pyruvate kinase family. (500 aa)
SAG0948Amino acid ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (209 aa)
coaAPantothenate kinase; Identified by match to PFAM protein family HMM PF00485. (306 aa)
SAG0955Sugar ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (511 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (819 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (520 aa)
SAG0974ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (250 aa)
pstB1Phosphate ABC transporter, ATP-binding protein PstB, putative; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (252 aa)
pstB2Phosphate ABC transporter, ATP-binding protein PstB, putative; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (267 aa)
SAG0997Macrolide-efflux protein mreA/riboflavin biosynthesis protein RibF; Identified by match to PFAM protein family HMM PF01687; Belongs to the ribF family. (310 aa)
SAG1004ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (233 aa)
SAG1008Iron compound ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (253 aa)
SAG1033Identified by match to PFAM protein family HMM PF01580. (1309 aa)
carBCarbamoyl-phosphate synthase, large subunit; Identified by match to PFAM protein family HMM PF00289. (1060 aa)
carA-1Carbamoyl-phosphate synthase, small subunit; Identified by match to PFAM protein family HMM PF00117; Belongs to the CarA family. (358 aa)
SAG1049ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (513 aa)
fhsFormate--tetrahydrofolate ligase; Identified by match to PFAM protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. (556 aa)
lplA-2Lipoate-protein ligase A; Identified by match to PFAM protein family HMM PF02539. (339 aa)
SAG1070ABC transporter, ATP-binding/permease protein; Identified by match to PFAM protein family HMM PF00005. (577 aa)
SAG1071ABC transporter, ATP-binding/permease protein; Identified by match to PFAM protein family HMM PF00005. (573 aa)
tdkThymidine kinases; Identified by match to PFAM protein family HMM PF00265. (189 aa)
nadKConserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (278 aa)
prsA-2Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa)
potASpermidine/putrescine ABC transporter, ATP-binding protein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (384 aa)
folK2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Identified by match to PFAM protein family HMM PF01288. (162 aa)
folCFolylpolyglutamate synthase; Identified by match to TIGR protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. (420 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (288 aa)
pcrAATP-dependent DNA helicase PcrA; Identified by match to PFAM protein family HMM PF00580. (759 aa)
parCDNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. (819 aa)
parEDNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily. (653 aa)
cpsDcpsD protein; Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide (By similarity). (229 aa)
SAG1187ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (253 aa)
miaAtRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (296 aa)
SAG1257Cation-transporting ATPase, E1-E2 family; Identified by match to PFAM protein family HMM PF00122. (709 aa)
SAG1262Cation-transporting ATPase, E1-E2 family; Identified by match to PFAM protein family HMM PF00122. (695 aa)
SAG1280SNF2 family protein; Identified by match to PFAM protein family HMM PF00176. (2274 aa)
SAG1303ATP-dependent Clp protease, ATP-binding subunit; Identified by match to PFAM protein family HMM PF00004; Belongs to the ClpA/ClpB family. (702 aa)
clpXATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (408 aa)
SAG1320Conserved hypothetical protein TIGR00147; Identified by Glimmer2; putative. (304 aa)
SAG1324Phosphomevalonate kinase; Identified by match to TIGR protein family HMM TIGR01220. (330 aa)
mvaDDiphosphomevalonate decarboxylase; Identified by match to PFAM protein family HMM PF00288. (314 aa)
SAG1326Mevalonate kinase, putative; Identified by match to PFAM protein family HMM PF00288. (292 aa)
SAG1337ABC transporter, ATP-binding/permease protein; Identified by match to PFAM protein family HMM PF00005. (589 aa)
SAG1338ABC transporter, ATP-binding/permease protein; Identified by match to PFAM protein family HMM PF00005. (579 aa)
SAG1340ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (622 aa)
ccapolyA polymerase family protein; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (402 aa)
fruK1-phosphofructokinase; Identified by match to PFAM protein family HMM PF00294; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (303 aa)
SAG1360ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (236 aa)
SAG1362Carbamoyl-phosphate synthase, large subunit, putative; Identified by match to PFAM protein family HMM PF02787. (532 aa)
carA-2Carbamoyl-phosphate synthase, small subunit; Identified by match to PFAM protein family HMM PF00117; Belongs to the CarA family. (356 aa)
thiIThiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (404 aa)
cmkCytidylate kinase; Identified by match to PFAM protein family HMM PF02224. (227 aa)
murEUDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (484 aa)
SAG1392Iron compound ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (264 aa)
secA2Preprotein translocase SecA subunit, putative; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (795 aa)
uvrBExcinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (663 aa)
SAG1467Glutamine ABC transporter, ATP-binding protein, GlnQ putative; Identified by match to PFAM protein family HMM PF00005. (246 aa)
SAG1487ABC transporter, ATP binding protein; Identified by match to PFAM protein family HMM PF00005. (233 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (195 aa)
dgkADiacylglycerol kinase; Identified by match to PFAM protein family HMM PF01219. (132 aa)
SAG1507PhoH family protein; Identified by match to PFAM protein family HMM PF02562. (345 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (242 aa)
SAG1514Peptide ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (226 aa)
SAG1515Peptide ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (262 aa)
ftsKFtsK/SpoIIIE family protein; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the difSL recombination site, which is located within the replication terminus region. Required for activation of the XerS recombinase, allowing activation of chromosome unlinking by recombination (By similarity). Belongs to the FtsK/SpoIIIE/SftA family. (816 aa)
SAG1532Manganese ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (238 aa)
metGmethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (665 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (211 aa)
livFBranched-chain amino acid ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (236 aa)
livGBranched-chain amino acid ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (254 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (443 aa)
SAG1618Snf2 family protein; Identified by match to PFAM protein family HMM PF00176; The product of this gene was detected by Western blot analysis. For details on the method see Tettelin et al. 2002. (1032 aa)
dnaIPrimosomal protein DnaI. (300 aa)
nrdRConserved hypothetical protein TIGR00244; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (159 aa)
SAG1633ABC transporter, ATP-binding protein; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). (558 aa)
metNABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (356 aa)
tmcALConserved hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. (369 aa)
nadDConserved hypothetical protein TIGR00482; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (210 aa)
gatBglutamyl-tRNA(Gln) amidotransferase, B subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (480 aa)
gatAglutamyl-tRNA(Gln) amidotransferase, A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (488 aa)
gatCglutamyl-tRNA(Gln) amidotransferase, C subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (100 aa)
ppdKPyruvate phosphate dikinase; Identified by match to PFAM protein family HMM PF00391; Belongs to the PEP-utilizing enzyme family. (881 aa)
SAG1671Protein of unknown function; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (276 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (671 aa)
secAPreprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (842 aa)
uvrAExcinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (942 aa)
mutS2MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (779 aa)
recD2Helicase, putative; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (806 aa)
cydCABC transporter, ATP-binding protein CydC; Identified by match to PFAM protein family HMM PF00005. (582 aa)
SAG1740ABC transporter, ATP-binding protein CydD; Identified by match to PFAM protein family HMM PF00005. (572 aa)
pgkPhosphoglycerate kinase; Identified by match to PFAM protein family HMM PF00162; Belongs to the phosphoglycerate kinase family. (398 aa)
SAG1775Conserved hypothetical protein; Identified by Glimmer2; putative. (210 aa)
dltAD-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...] (511 aa)
dltSSensor histidine kinase; Member of the two-component regulatory system DltS/DltR. Regulates the expression of the dlt operon. Probably phosphorylates DltR (By similarity). (395 aa)
SAG1797Amino acid ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (407 aa)
gshABGlutamate--cysteine ligase/amino acid ligase, putative; Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine. (750 aa)
SAG1826Identified by match to PFAM protein family HMM PF01712. (213 aa)
SAG1828ATP-dependent Clp protease, ATP-binding subunit; Identified by match to PFAM protein family HMM PF00004; Belongs to the ClpA/ClpB family. (815 aa)
SAG1870Prophage LambdaSa2, DNA replication protein DnaC, putative. (273 aa)
dnaC-1Prophage LambdaSa2, replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (443 aa)
proSprolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (617 aa)
SAG1925Sugar ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005; Belongs to the ABC transporter superfamily. (377 aa)
lacCTagatose-6-phosphate kinase; Identified by match to PFAM protein family HMM PF00294; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (310 aa)
SAG1940GTP pyrophosphokinase family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (738 aa)
SAG1955ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (282 aa)
pstB3Phosphate ABC transporter, ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (253 aa)
SAG1978ATPase, AAA family; Identified by match to PFAM protein family HMM PF00004. (422 aa)
SAG1980ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (300 aa)
SAG2014Hypothetical protein; Identified by Glimmer2; putative. (449 aa)
SAG2018Identified by match to PFAM protein family HMM PF01580. (553 aa)
SAG2027ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (205 aa)
SAG2035ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (300 aa)
leuSleucyl-tRNA synthetase; Identified by match to PFAM protein family HMM PF00133; Belongs to the class-I aminoacyl-tRNA synthetase family. (833 aa)
groEL60 kda chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (540 aa)
groESChaperonin, 10 kDa; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (94 aa)
SAG2076ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (267 aa)
nrdDAnaerobic ribonucleoside-triphosphate reductase; Identified by match to PFAM protein family HMM PF01228. (723 aa)
recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (379 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (196 aa)
hexBDNA mismatch repair protein HexB; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (659 aa)
hexADNA mismatch repair protein HexA; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (858 aa)
argSarginyl-tRNA synthetase; Identified by match to PFAM protein family HMM PF00750. (563 aa)
aspSaspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (583 aa)
hisShistidyl-tRNA synthetase; Identified by match to PFAM protein family HMM PF00587. (426 aa)
SAG2119Conserved domain protein; Similar to GP:15161770; identified by sequence similarity; putative. (373 aa)
SAG2129Amino acid ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (240 aa)
dnaC-2Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (451 aa)
trmUtRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (373 aa)
ecfA2ABC transporter, ATP-binding protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (280 aa)
ecfA1ABC transporter, ATP-binding protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (279 aa)
recFrecF protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (369 aa)
trpStryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (341 aa)
SAG2171ABC transporter, ATP-binding protein; Identified by match to PFAM protein family HMM PF00005. (539 aa)
Your Current Organism:
Streptococcus agalactiae
NCBI taxonomy Id: 208435
Other names: S. agalactiae 2603V/R, Streptococcus agalactiae 2603V/R, Streptococcus agalactiae str. 2603V/R
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