STRINGSTRING
gnd gnd AIG72961.1 AIG72961.1 AIG73017.1 AIG73017.1 AIG73359.1 AIG73359.1 glmD glmD dasR dasR AIG73362.1 AIG73362.1 pdxH pdxH glpD1 glpD1 prs prs glmU glmU eno1 eno1 glpX glpX AIG73915.1 AIG73915.1 AIG73916.1 AIG73916.1 AIG73917.1 AIG73917.1 AIG73918.1 AIG73918.1 AIG73919.1 AIG73919.1 manA manA AIG73921.1 AIG73921.1 dhaK dhaK AIG74182.1 AIG74182.1 AIG74183.1 AIG74183.1 AIG74211.1 AIG74211.1 AIG74284.1 AIG74284.1 AIG74453.1 AIG74453.1 AIG74573.1 AIG74573.1 gpsA2 gpsA2 AIG74814.1 AIG74814.1 anmK anmK fas2 fas2 fas3 fas3 rbsK rbsK glmS1 glmS1 rbsR rbsR AIG75644.1 AIG75644.1 AIG75698.1 AIG75698.1 AIG75702.1 AIG75702.1 AIG75762.1 AIG75762.1 glpK1 glpK1 AIG75923.1 AIG75923.1 glpK2 glpK2 glpD2 glpD2 eno2 eno2 pdxS pdxS pdxT pdxT xylA xylA AIG76688.1 AIG76688.1 AIG76854.1 AIG76854.1 AIG77033.1 AIG77033.1 xyoA xyoA glk glk AIG77765.1 AIG77765.1 tkt tkt tal tal pgi pgi zwf zwf AIG77815.1 AIG77815.1 pgl pgl tpiA tpiA pgk pgk gapA gapA rpe rpe AIG77893.1 AIG77893.1 AIG77894.1 AIG77894.1 AIG77895.1 AIG77895.1 nagE nagE AIG77897.1 AIG77897.1 AIG77898.1 AIG77898.1 ppgK ppgK AIG78180.1 AIG78180.1 pyk pyk pfp pfp AIG78192.1 AIG78192.1 AIG78197.1 AIG78197.1 edd edd AIG78281.1 AIG78281.1 AIG78809.1 AIG78809.1 AIG78939.1 AIG78939.1 AIG79023.1 AIG79023.1 AIG79024.1 AIG79024.1 AIG79208.1 AIG79208.1 AIG79428.1 AIG79428.1 AIG79570.1 AIG79570.1 AIG79764.1 AIG79764.1 glpD glpD AIG79798.1 AIG79798.1 glpK3 glpK3 AIG79800.1 AIG79800.1 AIG79818.1 AIG79818.1 xylB xylB glmS2 glmS2 glmM glmM gpmA gpmA AIG80313.1 AIG80313.1 AIG80577.1 AIG80577.1 AIG80578.1 AIG80578.1 AIG80579.1 AIG80579.1 AIG80580.1 AIG80580.1 AIG80581.1 AIG80581.1 AIG80582.1 AIG80582.1 AIG80583.1 AIG80583.1 AIG80584.1 AIG80584.1 AIG80585.1 AIG80585.1 AIG80586.1 AIG80586.1 murQ murQ AIG80942.1 AIG80942.1 fba fba AIG80975.1 AIG80975.1 AIG80988.1 AIG80988.1 AIG81096.1 AIG81096.1 ptsI ptsI rbsK-2 rbsK-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gnd6-phosphogluconate dehydrogenase. (296 aa)
AIG72961.1Hypothetical protein. (213 aa)
AIG73017.1Putative ribose-phosphate pyrophosphokinase. (315 aa)
AIG73359.1Hypothetical protein. (316 aa)
glmDGlucosamine-6-phosphate deaminase. (347 aa)
dasRHTH-type transcriptional repressor DasR. (251 aa)
AIG73362.1MFS transporter multidrug efflux transporter; Belongs to the major facilitator superfamily. (501 aa)
pdxHPyridoxine/pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (231 aa)
glpD1Glycerol-3-phosphate dehydrogenase 1; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (513 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
glmUBifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (495 aa)
eno1Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
glpXFructose-1,6-bisphosphatase class 2. (356 aa)
AIG73915.1Hypothetical protein. (143 aa)
AIG73916.1Hypothetical protein. (88 aa)
AIG73917.1Hypothetical protein. (451 aa)
AIG73918.1Hypothetical protein; Belongs to the UPF0434 family. (73 aa)
AIG73919.1Hypothetical protein. (363 aa)
manAMannose-6-phosphate isomerase. (409 aa)
AIG73921.1Conserved putative membrane protein. (169 aa)
dhaKPTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK. (333 aa)
AIG74182.1Dihydroxyacetone kinase, L subunit. (207 aa)
AIG74183.1Hypothetical protein. (224 aa)
AIG74211.1Hypothetical protein. (217 aa)
AIG74284.1Hypothetical protein. (143 aa)
AIG74453.1Sugar isomerase. (351 aa)
AIG74573.1L-threonine 3-dehydrogenase. (325 aa)
gpsA2Glycerol-3-phosphate dehydrogenase [NAD(P)+] 2; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (337 aa)
AIG74814.1Na+/solute symporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (527 aa)
anmKAnhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (402 aa)
fas2Ferredoxin fas2. (230 aa)
fas3Putative 33.6 kDa protein in fasciation locus. (294 aa)
rbsKHypothetical protein; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (315 aa)
glmS1Glutamine-fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (606 aa)
rbsRLacI family transcriptional regulator. (326 aa)
AIG75644.1Xylulokinase; Belongs to the FGGY kinase family. (507 aa)
AIG75698.1Conserved putative secreted protein. (376 aa)
AIG75702.1Hypothetical protein. (326 aa)
AIG75762.1Cytidylate kinase. (224 aa)
glpK1Glycerol kinase 1; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (650 aa)
AIG75923.1Conserved putative membrane protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (273 aa)
glpK2Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (505 aa)
glpD2Glycerol-3-phosphate dehydrogenase 2; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (564 aa)
eno2Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (304 aa)
pdxTGlutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (209 aa)
xylAXylose isomerase; Belongs to the xylose isomerase family. (389 aa)
AIG76688.1Hypothetical protein. (264 aa)
AIG76854.1Hypothetical protein. (291 aa)
AIG77033.1Hypothetical protein. (341 aa)
xyoAPutative xylitol oxidase. (407 aa)
glkGlucokinase. (299 aa)
AIG77765.1Hypothetical protein. (241 aa)
tktTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (700 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (370 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (545 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (509 aa)
AIG77815.1Oxppcycle protein. (334 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (251 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (261 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (404 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
rpeRibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (227 aa)
AIG77893.1PTS system, glucose/maltose/N-acetylglucosamine-specific IIA component. (151 aa)
AIG77894.1Hypothetical protein. (78 aa)
AIG77895.1GntR family transcriptional regulator. (262 aa)
nagEPTS system glucose/maltose/N-acetylglucosamine-specific transporter subunit IIC. (418 aa)
AIG77897.1Putative secreted protein. (88 aa)
AIG77898.1Hypothetical protein. (274 aa)
ppgKPolyphosphate glucokinase. (254 aa)
AIG78180.1acyl-CoA thioesterase II. (296 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (454 aa)
pfpPyrophosphate-fructose 6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (341 aa)
AIG78192.1Acyltransferase. (253 aa)
AIG78197.1Hypothetical protein. (324 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (629 aa)
AIG78281.1Hypothetical protein. (206 aa)
AIG78809.1Hypothetical protein. (139 aa)
AIG78939.1Phospholipid/glycerol acyltransferase. (256 aa)
AIG79023.1DeoR family transcriptional regulator. (261 aa)
AIG79024.1Hypothetical protein. (312 aa)
AIG79208.1Putative oxidoreductase. (295 aa)
AIG79428.1Putative oxidoreductase. (285 aa)
AIG79570.1Hypothetical protein. (163 aa)
AIG79764.1Hypothetical protein. (256 aa)
glpDGlycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (579 aa)
AIG79798.1Glycerol uptake facilitator protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (251 aa)
glpK3Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (503 aa)
AIG79800.1Hypothetical protein. (169 aa)
AIG79818.1Hypothetical protein. (545 aa)
xylBXylulose kinase. (475 aa)
glmS2Glutamine-fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (620 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (444 aa)
gpmA2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (249 aa)
AIG80313.16-phosphogluconate dehydrogenase, decarboxylating 2; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (479 aa)
AIG80577.1L-fuculose phosphate aldolase. (216 aa)
AIG80578.1Hypothetical protein. (482 aa)
AIG80579.1Hypothetical protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (344 aa)
AIG80580.1Ribose 5-phosphate isomerase B. (151 aa)
AIG80581.1Hypothetical protein. (561 aa)
AIG80582.1Beta-phosphoglucomutase. (228 aa)
AIG80583.1Hypothetical protein. (208 aa)
AIG80584.1Hypothetical protein. (264 aa)
AIG80585.1Conserved putative membrane protein. (444 aa)
AIG80586.1Carbohydrate kinase. (479 aa)
murQN-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (308 aa)
AIG80942.1Conserved putative secreted protein. (372 aa)
fbaFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (342 aa)
AIG80975.1Hypothetical protein. (397 aa)
AIG80988.1Hypothetical protein; Belongs to the carbohydrate kinase PfkB family. (291 aa)
AIG81096.1Glycerophosphoryl diester phosphodiesterase. (343 aa)
ptsIPhosphotransferase system EI component; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (544 aa)
rbsK-2Hypothetical protein; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (286 aa)
Your Current Organism:
Amycolatopsis japonica
NCBI taxonomy Id: 208439
Other names: A. japonica, Amycolatopsis japonicum, CIP 106801, DSM 44213, JCM 10140, NRRL B-24138, strain MG417-CF17
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