STRINGSTRING
AIG73420.1 AIG73420.1 citA citA gltA2 gltA2 fumC fumC AIG73971.1 AIG73971.1 kgd kgd ilvX ilvX icl icl aceB1 aceB1 pyc pyc lipA1 lipA1 aceB2 aceB2 mtr mtr AIG74972.1 AIG74972.1 AIG74974.1 AIG74974.1 lldD lldD aceE aceE lipA2 lipA2 lipB lipB AIG75027.1 AIG75027.1 AIG75028.1 AIG75028.1 AIG75999.1 AIG75999.1 AIG76060.1 AIG76060.1 sucD1 sucD1 sucC1 sucC1 AIG76479.1 AIG76479.1 bkdB bkdB AIG76481.1 AIG76481.1 mdh mdh acnA acnA fumA fumA lpd lpd icd icd sucD2 sucD2 sucC2 sucC2 AIG79947.1 AIG79947.1 korA korA korB korB bkdA bkdA pdhB pdhB AIG81080.1 AIG81080.1 pckG pckG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AIG73420.1NAD-dependent malic enzyme. (466 aa)
citAPutative citrate synthase 2; Belongs to the citrate synthase family. (383 aa)
gltA2Citrate synthase 1; Belongs to the citrate synthase family. (438 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa)
AIG73971.1NAD-dependent malic enzyme. (409 aa)
kgdMultifunctional 2-oxoglutarate metabolism enzyme. (1240 aa)
ilvXPutative acetolactate synthase large subunit IlvX. (520 aa)
iclIsocitrate lyase. (428 aa)
aceB1Malate synthase; Belongs to the malate synthase family. (534 aa)
pycPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1125 aa)
lipA1Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (333 aa)
aceB2Malate synthase; Belongs to the malate synthase family. (525 aa)
mtrMycothione reductase. (464 aa)
AIG74972.1Hypothetical protein. (242 aa)
AIG74974.1Hypothetical protein. (464 aa)
lldDPutative L-lactate dehydrogenase [cytochrome]. (403 aa)
aceEPyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (931 aa)
lipA2Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (333 aa)
lipBOctanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (247 aa)
AIG75027.1Hypothetical protein. (587 aa)
AIG75028.1Dihydrolipoyl dehydrogenase. (457 aa)
AIG75999.1Hypothetical protein. (1149 aa)
AIG76060.1Hypothetical protein. (330 aa)
sucD1Succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa)
sucC1Succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (387 aa)
AIG76479.1Hypothetical protein. (397 aa)
bkdB3-methyl-2-oxobutanoate dehydrogenase subunit beta. (332 aa)
AIG76481.1Hypothetical protein. (362 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
acnAAconitate hydratase. (935 aa)
fumAFumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (552 aa)
lpdDihydrolipoyl dehydrogenase. (461 aa)
icdIsocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (407 aa)
sucD2Succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)
sucC2Succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa)
AIG79947.1Hypothetical protein. (119 aa)
korA2-oxoglutarate oxidoreductase subunit KorA. (635 aa)
korB2-oxoglutarate oxidoreductase subunit KorB. (354 aa)
bkdA3-methyl-2-oxobutanoate dehydrogenase subunit alpha. (401 aa)
pdhBPyruvate dehydrogenase E1 component subunit beta. (330 aa)
AIG81080.1Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase. (446 aa)
pckGPhosphoenolpyruvate carboxykinase [GTP]; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (607 aa)
Your Current Organism:
Amycolatopsis japonica
NCBI taxonomy Id: 208439
Other names: A. japonica, Amycolatopsis japonicum, CIP 106801, DSM 44213, JCM 10140, NRRL B-24138, strain MG417-CF17
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