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| | AIG77522.1 | Hypothetical protein. (432 aa) |
| | AIG77559.1 | Hypothetical protein. (417 aa) |
| | AIG77570.1 | Carbamoyl-phosphate synthase large chain. (426 aa) |
| | AIG77576.1 | Phosphoribosylglycinamide synthetase. (418 aa) |
| | AIG77579.1 | Hypothetical protein. (135 aa) |
| | thiL-3 | Hypothetical protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (360 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (757 aa) |
| | cysD2 | Sulfate adenylyltransferase subunit 2. (302 aa) |
| | cysNC | Bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Catalyzes the synthesis of activated sulfate. Belongs to the APS kinase family. (608 aa) |
| | ggt | Gamma-glutamyltranspeptidase. (603 aa) |
| | AIG77921.1 | Hypothetical protein; Belongs to the eIF-2B alpha/beta/delta subunits family. (336 aa) |
| | mtnC | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (238 aa) |
| | mtnD | Acireductone dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (192 aa) |
| | AIG79770.1 | Hypothetical protein. (141 aa) |
| | AIG79928.1 | Hypothetical protein. (160 aa) |
| | AIG80002.1 | acetyl/propionyl-CoA carboxylase, carboxyltransferase subunit. (443 aa) |
| | AIG80129.1 | Hypothetical protein. (126 aa) |
| | AIG80139.1 | Conserved putative secreted protein. (224 aa) |
| | AIG80151.1 | GlcNAc-PI de-N-acetylase. (229 aa) |
| | AIG80222.1 | Hypothetical protein. (360 aa) |
| | mshA | D-inositol 3-phosphate glycosyltransferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. (434 aa) |
| | AIG80443.1 | Putative pyridoxal phosphate-dependent protein. (372 aa) |
| | AIG80471.1 | Hypothetical protein. (328 aa) |
| | AIG80550.1 | Hypothetical protein. (90 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (346 aa) |
| | AIG80803.1 | Putative nucleoside kinase, CMP and AMP kinase. (345 aa) |
| | mshD | Mycothiol acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. (291 aa) |
| | bkdA | 3-methyl-2-oxobutanoate dehydrogenase subunit alpha. (401 aa) |
| | moeZ | Putative adenylyltransferase/sulfurtransferase MoeZ. (392 aa) |
| | AIG73615.1 | Hypothetical protein. (515 aa) |
| | AIG73463.1 | Hypothetical protein. (499 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (547 aa) |
| | thiD2 | Hydroxymethylpyrimidine/phosphomethylpyrimidinek inase. (273 aa) |
| | thiD1 | Hydroxymethylpyrimidine/phosphomethylpyrimidinek inase. (276 aa) |
| | thiG | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (252 aa) |
| | AIG73367.1 | Hypothetical protein. (66 aa) |
| | AIG73366.1 | Hypothetical protein. (357 aa) |
| | thiE | Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (221 aa) |
| | AIG73335.1 | Conserved putative membrane protein. (535 aa) |
| | AIG73309.1 | Hypothetical protein. (210 aa) |
| | acsA1 | Acetyl-coenzyme A synthetase 1. (658 aa) |
| | AIG73046.1 | Putative gamma-glutamyltranspeptidase. (587 aa) |
| | AIG72996.1 | Hypothetical protein. (359 aa) |
| | cysM | O-phosphoserine sulfhydrylase. (316 aa) |
| | AIG74218.1 | Hypothetical protein. (90 aa) |
| | mec | CysO-cysteine peptidase. (138 aa) |
| | AIG74189.1 | Methionine gamma-lyase. (372 aa) |
| | hom | Homoserine dehydrogenase. (436 aa) |
| | AIG74089.1 | Hypothetical protein. (396 aa) |
| | AIG74088.1 | Hypothetical protein. (348 aa) |
| | AIG74060.1 | Hypothetical protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (423 aa) |
| | AIG74537.1 | Hypothetical protein. (345 aa) |
| | AIG74590.1 | Cystathionine beta-synthase. (352 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (318 aa) |
| | lipA1 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (333 aa) |
| | metH | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1202 aa) |
| | AIG74939.1 | 8-amino-7-oxononanoate synthase. (395 aa) |
| | lipA2 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (333 aa) |
| | bioA | Adenosylmethionine-8-amino-7- oxononanoateaminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (426 aa) |
| | bioD | ATP-dependent dethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (235 aa) |
| | metX | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (364 aa) |
| | mshB | 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway. (280 aa) |
| | metB | Cystathionine gamma-synthase. (397 aa) |
| | AIG73811.1 | Putative cystathionine beta-synthase. (456 aa) |
| | AIG73760.1 | Hypothetical protein. (162 aa) |
| | AIG73697.1 | Hypothetical protein. (623 aa) |
| | AIG73659.1 | Hypothetical protein. (135 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (634 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (297 aa) |
| | AIG78687.1 | Conserved putative membrane protein. (744 aa) |
| | cysD | Sulfate adenylyltransferase subunit 2. (306 aa) |
| | AIG78926.1 | Hypothetical protein. (133 aa) |
| | AIG78962.1 | Hypothetical protein. (500 aa) |
| | AIG78996.1 | Hypothetical protein. (243 aa) |
| | AIG79734.1 | Hypothetical protein. (235 aa) |
| | mtnAB | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (321 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (338 aa) |
| | AIG75328.1 | AMP-dependent synthetase and ligase. (497 aa) |
| | AIG75361.1 | 5-aminolevulinate synthase. (402 aa) |
| | AIG75651.1 | Hypothetical protein. (130 aa) |
| | AIG75738.1 | Conserved putative membrane protein. (393 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (393 aa) |
| | AIG75967.1 | Hypothetical protein. (139 aa) |
| | AIG76059.1 | Adenosylmethionine-8-amino-7- oxononanoatetransaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (454 aa) |
| | AIG76060.1 | Hypothetical protein. (330 aa) |
| | AIG76120.1 | Class III aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (415 aa) |
| | AIG76243.1 | Hypothetical protein. (352 aa) |
| | AIG76305.1 | dicarboxylate-CoA ligase PimA. (541 aa) |
| | AIG79049.1 | precorrin-3B synthase. (368 aa) |
| | AIG79229.1 | Hypothetical protein. (281 aa) |
| | metK | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (404 aa) |
| | AIG76477.1 | Hypothetical protein. (79 aa) |
| | thiL-2 | Hypothetical protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (352 aa) |
| | AIG76481.1 | Hypothetical protein. (362 aa) |
| | folD | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (277 aa) |
| | AIG76684.1 | Hypothetical protein. (110 aa) |
| | AIG76707.1 | Conserved putative secreted protein. (194 aa) |
| | sbnA | Putative siderophore biosynthesis protein SbnA. (331 aa) |
| | AIG76784.1 | Hypothetical protein. (395 aa) |
| | AIG76789.1 | Hypothetical protein. (437 aa) |
| | AIG76824.1 | Hypothetical protein. (246 aa) |
| | mshC | L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. (412 aa) |
| | egtD | Histidine-specific methyltransferase EgtD; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (325 aa) |
| | egtC | Hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. (254 aa) |
| | egtB | Iron(II)-dependent oxidoreductase EgtB; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. (449 aa) |
| | gshA | Glutamate-cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. (420 aa) |
| | AIG76974.1 | Hypothetical protein. (567 aa) |
| | AIG77049.1 | Putative pyridoxal phosphate-dependent protein. (349 aa) |
| | accD3 | Acetyl CoA carboxylase beta subunit. (418 aa) |
| | AIG77217.1 | Hypothetical protein. (527 aa) |
| | AIG77275.1 | Conserved putative membrane protein. (248 aa) |
| | AIG77364.1 | Hypothetical protein. (346 aa) |
| | AIG77425.1 | Biotin carboxylase. (421 aa) |
| | AIG77426.1 | Biotin carboxylase. (423 aa) |
