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rpsF rpsF rpsG rpsG rpsJ rpsJ rplC rplC rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rplP rplP rpmC rpmC rpsQ rpsQ rplN rplN rplX rplX rplE rplE rpsZ rpsZ rpsH rpsH rplF rplF rplR rplR rpsE rpsE rpmD rpmD rplO rplO rpmJ rpmJ rpsM rpsM rpsK rpsK rpsD rpsD rplQ rplQ rpmG rpmG rplK rplK rplA rplA rplJ rplJ rplL rplL rpsI rpsI rplM rplM rplK-2 rplK-2 SED69343.1 SED69343.1 rplY rplY rpmE rpmE SED38238.1 SED38238.1 rplU rplU rpmA rpmA rpsT rpsT rpsO rpsO SED20869.1 SED20869.1 rpmI rpmI rplT rplT rpmJ-2 rpmJ-2 SEC79602.1 SEC79602.1 rpsR-2 rpsR-2 rpsN rpsN rpmG-2 rpmG-2 rpmB-2 rpmB-2 rpmE2 rpmE2 rpmF-2 rpmF-2 SEC48028.1 SEC48028.1 SEC37106.1 SEC37106.1 SEC24605.1 SEC24605.1 rpsB rpsB rplS rplS rpsP rpsP rpmF rpmF rpmB rpmB rpmH rpmH rplI rplI rpsR rpsR rpsL rpsL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpsFSmall subunit ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (108 aa)
rpsGSSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsJSSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (101 aa)
rplCLarge subunit ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (218 aa)
rplDLarge subunit ribosomal protein L4; Forms part of the polypeptide exit tunnel. (229 aa)
rplWLarge subunit ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (103 aa)
rplBLarge subunit ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (278 aa)
rpsSSSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
rplVLarge subunit ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (139 aa)
rpsCSSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (277 aa)
rplPLSU ribosomal protein L16P; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (139 aa)
rpmCLarge subunit ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (82 aa)
rpsQSSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (92 aa)
rplNLSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplXLarge subunit ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (104 aa)
rplELSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (187 aa)
rpsZSSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rpsHSmall subunit ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rplFLarge subunit ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (179 aa)
rplRLSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (132 aa)
rpsESmall subunit ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (214 aa)
rpmDLarge subunit ribosomal protein L30. (71 aa)
rplOLarge subunit ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (148 aa)
rpmJLSU ribosomal protein L36P; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
rpsMSSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (126 aa)
rpsKSSU ribosomal protein S11P; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (135 aa)
rpsDSmall subunit ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (201 aa)
rplQLarge subunit ribosomal protein L17. (182 aa)
rpmGLarge subunit ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (54 aa)
rplKLSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (145 aa)
rplALarge subunit ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (239 aa)
rplJLSU ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (184 aa)
rplLLSU ribosomal protein L12P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (127 aa)
rpsISSU ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family. (166 aa)
rplMLSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (150 aa)
rplK-2Large subunit ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (142 aa)
SED69343.1Hypothetical protein. (103 aa)
rplYLarge subunit ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (199 aa)
rpmELarge subunit ribosomal protein L31; Binds the 23S rRNA. (75 aa)
SED38238.1Predicted kinase, aminoglycoside phosphotransferase (APT) family. (352 aa)
rplULarge subunit ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (104 aa)
rpmALSU ribosomal protein L27P; Belongs to the bacterial ribosomal protein bL27 family. (85 aa)
rpsTSmall subunit ribosomal protein S20; Binds directly to 16S ribosomal RNA. (86 aa)
rpsOSmall subunit ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
SED20869.1Small subunit ribosomal protein S1. (499 aa)
rpmILarge subunit ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (64 aa)
rplTLarge subunit ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (125 aa)
rpmJ-2LSU ribosomal protein L36P; Belongs to the bacterial ribosomal protein bL36 family. (40 aa)
SEC79602.1AAA ATPase domain-containing protein. (1378 aa)
rpsR-2SSU ribosomal protein S18P; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (81 aa)
rpsNSSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rpmG-2LSU ribosomal protein L33P; Belongs to the bacterial ribosomal protein bL33 family. (55 aa)
rpmB-2Large subunit ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (78 aa)
rpmE2LSU ribosomal protein L31P. (84 aa)
rpmF-2LSU ribosomal protein L32P; Belongs to the bacterial ribosomal protein bL32 family. (50 aa)
SEC48028.1Predicted kinase, aminoglycoside phosphotransferase (APT) family. (338 aa)
SEC37106.1Hypothetical protein. (105 aa)
SEC24605.1Predicted kinase, aminoglycoside phosphotransferase (APT) family. (309 aa)
rpsBSmall subunit ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (286 aa)
rplSLarge subunit ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (122 aa)
rpsPSmall subunit ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (147 aa)
rpmFLarge subunit ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (60 aa)
rpmBLarge subunit ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (63 aa)
rpmHLSU ribosomal protein L34P; Belongs to the bacterial ribosomal protein bL34 family. (47 aa)
rplILSU ribosomal protein L9P; Binds to the 23S rRNA. (153 aa)
rpsRSSU ribosomal protein S18P; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (82 aa)
rpsLSSU ribosomal protein S12P; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (124 aa)
Your Current Organism:
Amycolatopsis tolypomycina
NCBI taxonomy Id: 208445
Other names: A. tolypomycina, ATCC 21177, Amycolatopsis tolypomycina Wink et al. 2003, Amycolatopsis tolypophora, Amycolatopsis tolypophorous, DSM 44544, IFO 14664, IMSNU 20061, JCM 4936, NBRC 14664, NRRL B-24205, Streptomyces tolypophorus
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