STRINGSTRING
PA0012 PA0012 PA0109 PA0109 PA0308 PA0308 pilT pilT pilU pilU pilG pilG pilH pilH pilI pilI pilJ pilJ pilK pilK chpA chpA chpB chpB chpC chpC chpD chpD chpE chpE vfr vfr fimL fimL PA1825 PA1825 PA2797 PA2797 PA2798 PA2798 PA2799 PA2799 PA2829 PA2829 pilZ pilZ PA2989 PA2989 PA3091 PA3091 fimV fimV cyaB cyaB PA3275 PA3275 PA3276 PA3276 PA3740 PA3740 pilF pilF PA3966 PA3966 PA3967 PA3967 PA4278 PA4278 PA4437 PA4437 PA4441 PA4441 rpoN rpoN PA4523 PA4523 pilA pilA pilB pilB pilD pilD pilS pilS pilR pilR fimT fimT fimU fimU pilV pilV pilW pilW pilX pilX pilY1 pilY1 pilY2 pilY2 pilE pilE PA4608 PA4608 PA4702 PA4702 PA4703 PA4703 cbpA cbpA PA4724.1 PA4724.1 cbrA cbrA cbrB cbrB PA4851 PA4851 fimW fimW fimX fimX cpdA cpdA pilQ pilQ pilP pilP pilO pilO pilN pilN pilM pilM cyaA cyaA PA5330 PA5330 PA5515 PA5515 PA5527 PA5527
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PA0012Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (88 aa)
PA0109Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (69 aa)
PA0308Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (339 aa)
pilTTwitching motility protein PilT; May be involved in pilus retraction; Belongs to the GSP E family. (344 aa)
pilUTwitching motility protein PilU; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (382 aa)
pilGTwitching motility protein PilG; Is involved in pilus biosynthesis and twitching motility. May act as a single-domain response regulator whose function may be to receive a certain environmental signal(s) and then transduce that signal to the pilus assembly machinery via specific protein-protein interactions. (135 aa)
pilHTwitching motility protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). (121 aa)
pilITwitching motility protein PilI; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). (178 aa)
pilJTwitching motility protein PilJ; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). (682 aa)
pilKMethyltransferase PilK; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (291 aa)
chpAComponent of chemotactic signal transduction system; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (2472 aa)
chpBProbable methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (343 aa)
chpCProbable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (168 aa)
chpDProbable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (264 aa)
chpEProbable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (203 aa)
vfrTranscriptional regulator Vfr; Can bind cyclic AMP. Is a global regulator of virulence factor expression and is required for exotoxin A and protease production. (214 aa)
fimLHypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (562 aa)
PA1825Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (214 aa)
PA2797Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (160 aa)
PA2798Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (394 aa)
PA2799Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (99 aa)
PA2829Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (150 aa)
pilZType 4 fimbrial biogenesis protein PilZ; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (118 aa)
PA2989Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (254 aa)
PA3091Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (479 aa)
fimVMotility protein FimV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (919 aa)
cyaBCyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (463 aa)
PA3275Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (109 aa)
PA3276Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (140 aa)
PA3740Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (228 aa)
pilFType 4 fimbrial biogenesis protein PilF; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (252 aa)
PA3966Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (69 aa)
PA3967Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (130 aa)
PA4278Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (234 aa)
PA4437Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (320 aa)
PA4441Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (148 aa)
rpoNRNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (497 aa)
PA4523Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (751 aa)
pilAType 4 fimbrial precursor PilA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the N-Me-Phe pilin family. (149 aa)
pilBType 4 fimbrial biogenesis protein PilB; Involved in the translocation of the type IV pilin (PilA); Belongs to the GSP E family. (566 aa)
pilDType 4 prepilin peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. Processes the pilin precursor during membrane translocation. Required for the assembly of type IV pili and for secretion of most proteins. (290 aa)
pilSTwo-component sensor PilS; Member of the two-component regulatory system PilS/PilR involved in the regulation of the expression of type 4 fimbriae. PilS may function as a membrane-associated protein kinase that phosphorylates PilR in response to environmental signals. (530 aa)
pilRTwo-component response regulator PilR; Member of the two-component regulatory system PilS/PilR that regulates the expression of type 4 fimbriae. When activated by PilS it acts in conjunction with sigma-54 as a transcriptional activator. (445 aa)
fimTType 4 fimbrial biogenesis protein FimT; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (169 aa)
fimUType 4 fimbrial biogenesis protein FimU; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (168 aa)
pilVType 4 fimbrial biogenesis protein PilV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (185 aa)
pilWType 4 fimbrial biogenesis protein PilW; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (274 aa)
pilXType 4 fimbrial biogenesis protein PilX; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (195 aa)
pilY1Type 4 fimbrial biogenesis protein PilY1; Involved in pilus assembly, twitching motility and adhesion to host cells. Primes type IV pili (T4P) assembly and is required for inclusion of minor pilins PilV, PilW and PilX to the surface pili. Stabilizes assembled pilus fibers likely by antagonizing retraction mediated by PilT. Calcium-binding and calcium release by PilY1 seem to be essential for twitching motility and for regulation of pilus retraction dynamics of PilT (By similarity). (1161 aa)
pilY2Type 4 fimbrial biogenesis protein PilY2; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (115 aa)
pilEType 4 fimbrial biogenesis protein PilE; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (141 aa)
PA4608Hypothetical protein; Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second-messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a possible effector protein. (125 aa)
PA4702Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (115 aa)
PA4703Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (90 aa)
cbpAcAMP-binding protein A; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (265 aa)
PA4724.1Conserved hypothetical protein; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (58 aa)
cbrATwo-component sensor CbrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (983 aa)
cbrBTwo-component response regulator CbrB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (478 aa)
PA4851Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (421 aa)
fimWHypothetical protein; High-affinity cyclic-di-GMP binding protein that regulates type IV pili (T4P) elongation. Required for T4P-mediated surface attachment and walking motility during the early phases of surface colonization. Not required for twitching motility. Does not bind related nucleotides such as GMP, GDP, GTP or ATP. (487 aa)
fimXFimX; Class 1: Function experimentally demonstrated in P. aeruginosa. (691 aa)
cpdACyclic AMP (cAMP) Phosphodiesterase, CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (272 aa)
pilQType 4 fimbrial biogenesis outer membrane protein PilQ precursor; Essential for the formation of pili. Involved in the biogenesis of type 4 fimbriae probably by serving as a 'porthole' allowing passage of the fimbrae through the outer membrane; Belongs to the bacterial secretin family. PilQ subfamily. (714 aa)
pilPType 4 fimbrial biogenesis protein PilP; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (174 aa)
pilOType 4 fimbrial biogenesis protein PilO; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (207 aa)
pilNType 4 fimbrial biogenesis protein PilN; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (198 aa)
pilMType 4 fimbrial biogenesis protein PilM; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (354 aa)
cyaAAdenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein). (950 aa)
PA5330Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (205 aa)
PA5515Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (166 aa)
PA5527Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (133 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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