18 items (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hemO	Heme oxygenase; Involved in heme degradation. Catalyzes the degradation of heme to biliverdin, with the release of iron. Forms biliverdin delta (70%) and beta (30%). (198 aa)
	PA1245	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (414 aa)
	aprD	Alkaline protease secretion protein AprD; Involved in the secretion of alkaline protease; Belongs to the ABC transporter superfamily. Alkaline protease exporter (TC 3.A.1.110.4) family. (593 aa)
	aprE	Alkaline protease secretion protein AprE; Involved in the secretion of alkaline protease; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (432 aa)
	aprF	Alkaline protease secretion outer membrane protein AprF precursor; Involved in the secretion of alkaline protease; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. (481 aa)
	aprA	Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family. (479 aa)
	aprI	Alkaline proteinase inhibitor AprI; Inhibitor of the alkaline protease. It forms a non-covalent bond with the protease and may prevent its autocatalytic cleavage in the periplasm (By similarity). (131 aa)
	PA3404	Probable outer membrane protein precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (451 aa)
	hasE	Metalloprotease secretion protein; Product name confidence: Class 2 (High similarity to functionally studied protein). (443 aa)
	hasD	Transport protein HasD; Product name confidence: Class 2 (High similarity to functionally studied protein). (600 aa)
	hasAp	Heme acquisition protein HasAp; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (205 aa)
	hasR	Heme uptake outer membrane receptor HasR precursor; Product name confidence: Class 2 (High similarity to functionally studied protein). (891 aa)
	PA4141	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (99 aa)
	PA4142	Probable secretion protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (418 aa)
	PA4143	Probable toxin transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (719 aa)
	PA4144	Probable outer membrane protein precursor; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. (471 aa)
	PA4146	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (134 aa)
	phuR	Heme/hemoglobin uptake outer membrane receptor PhuR precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (764 aa)

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PA1245	aprA	PA1245	PA1249	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family.	0.744
PA1245	aprD	PA1245	PA1246	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Alkaline protease secretion protein AprD; Involved in the secretion of alkaline protease; Belongs to the ABC transporter superfamily. Alkaline protease exporter (TC 3.A.1.110.4) family.	0.951
PA1245	aprE	PA1245	PA1247	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Alkaline protease secretion protein AprE; Involved in the secretion of alkaline protease; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.933
PA1245	aprF	PA1245	PA1248	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Alkaline protease secretion outer membrane protein AprF precursor; Involved in the secretion of alkaline protease; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.	0.877
PA1245	aprI	PA1245	PA1250	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Alkaline proteinase inhibitor AprI; Inhibitor of the alkaline protease. It forms a non-covalent bond with the protease and may prevent its autocatalytic cleavage in the periplasm (By similarity).	0.901
PA3404	PA4142	PA3404	PA4142	Probable outer membrane protein precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Probable secretion protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.439
PA3404	PA4143	PA3404	PA4143	Probable outer membrane protein precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Probable toxin transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.423
PA3404	aprA	PA3404	PA1249	Probable outer membrane protein precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family.	0.627
PA3404	aprD	PA3404	PA1246	Probable outer membrane protein precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Alkaline protease secretion protein AprD; Involved in the secretion of alkaline protease; Belongs to the ABC transporter superfamily. Alkaline protease exporter (TC 3.A.1.110.4) family.	0.531
PA3404	aprE	PA3404	PA1247	Probable outer membrane protein precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Alkaline protease secretion protein AprE; Involved in the secretion of alkaline protease; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.717
PA3404	aprF	PA3404	PA1248	Probable outer membrane protein precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Alkaline protease secretion outer membrane protein AprF precursor; Involved in the secretion of alkaline protease; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.	0.560
PA3404	hasAp	PA3404	PA3407	Probable outer membrane protein precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Heme acquisition protein HasAp; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.593
PA3404	hasD	PA3404	PA3406	Probable outer membrane protein precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Transport protein HasD; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.975
PA3404	hasE	PA3404	PA3405	Probable outer membrane protein precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Metalloprotease secretion protein; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.939
PA3404	hasR	PA3404	PA3408	Probable outer membrane protein precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Heme uptake outer membrane receptor HasR precursor; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.599
PA4141	PA4142	PA4141	PA4142	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Probable secretion protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.830
PA4141	PA4143	PA4141	PA4143	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Probable toxin transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.576
PA4141	PA4144	PA4141	PA4144	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Probable outer membrane protein precursor; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.	0.888
PA4141	aprA	PA4141	PA1249	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family.	0.497
PA4142	PA3404	PA4142	PA3404	Probable secretion protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Probable outer membrane protein precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.439