17 items (Pseudomonas aeruginosa) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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experimentally determined

Predicted Interactions

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Your Input:
	purN	Phosphoribosylaminoimidazole synthetase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (222 aa)
	purD	Phosphoribosylamine--glycine ligase; Product name confidence: Class 2 (High similarity to functionally studied protein). (429 aa)
	purU2	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (285 aa)
	purK	Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (360 aa)
	purE	Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa)
	PA1944	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (495 aa)
	pvdF	Pyoverdine synthetase F; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (275 aa)
	purB	Adenylosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein). (456 aa)
	purF	Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (501 aa)
	PA3517	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa)
	purT	Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (393 aa)
	purL	Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1298 aa)
	purU1	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (283 aa)
	purH	Phosphoribosylaminoimidazolecarboxamide formyltransferase; Product name confidence: Class 2 (High similarity to functionally studied protein). (535 aa)
	PA1345	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (529 aa)
	purC	Phosphoribosylaminoimidazole-succinocarboxamide synthase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the SAICAR synthetase family. (236 aa)
	purM	Phosphoribosylaminoimidazole synthetase; Product name confidence: Class 2 (High similarity to functionally studied protein). (353 aa)

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PA3517	purB	PA3517	PA2629	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Adenylosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.900
PA3517	purC	PA3517	PA1013	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Phosphoribosylaminoimidazole-succinocarboxamide synthase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the SAICAR synthetase family.	0.989
PA3517	purD	PA3517	PA4855	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Phosphoribosylamine--glycine ligase; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.733
PA3517	purE	PA3517	PA5426	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).	0.714
PA3517	purF	PA3517	PA3108	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.812
PA3517	purH	PA3517	PA4854	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Phosphoribosylaminoimidazolecarboxamide formyltransferase; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.975
PA3517	purK	PA3517	PA5425	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family.	0.675
PA3517	purL	PA3517	PA3763	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.	0.957
PA3517	purM	PA3517	PA0945	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Phosphoribosylaminoimidazole synthetase; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.768
PA3517	purN	PA3517	PA0944	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Phosphoribosylaminoimidazole synthetase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.	0.624
PA3517	pvdF	PA3517	PA2396	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Pyoverdine synthetase F; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.624
purB	PA3517	PA2629	PA3517	Adenylosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.900
purB	purC	PA2629	PA1013	Adenylosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Phosphoribosylaminoimidazole-succinocarboxamide synthase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the SAICAR synthetase family.	0.989
purB	purD	PA2629	PA4855	Adenylosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Phosphoribosylamine--glycine ligase; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.934
purB	purE	PA2629	PA5426	Adenylosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).	0.848
purB	purF	PA2629	PA3108	Adenylosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.923
purB	purH	PA2629	PA4854	Adenylosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Phosphoribosylaminoimidazolecarboxamide formyltransferase; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.997
purB	purK	PA2629	PA5425	Adenylosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family.	0.911
purB	purL	PA2629	PA3763	Adenylosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.	0.983
purB	purM	PA2629	PA0945	Adenylosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Phosphoribosylaminoimidazole synthetase; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.985